World's Best Scientists 2026 revealed!
Jiahuai Han

Jiahuai Han

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Biology and Biochemistry
China
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
138
Citations
74378
World Ranking
298
National Ranking
4

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in China Leader Award
  • 2025 - Research.com Biology and Biochemistry in China Leader Award
  • 2023 - Research.com Biology and Biochemistry in China Leader Award
  • 2022 - Research.com Biology and Biochemistry in China Leader Award

Overview

Jiahuai Han is affiliated with Xiamen University in China, focusing their research primarily within the broad field of Biochemistry, Genetics and Molecular Biology. Their work spans several subfields, with a significant emphasis on Molecular Biology, Immunology, Spectroscopy, Epidemiology, and Cancer Research.

The scientist has contributed to a range of topics, including:

  • Cell death mechanisms and regulation
  • Inflammasome and immune disorders
  • Cell image analysis techniques
  • Interferon and immune responses
  • Advanced proteomics techniques and applications
  • Single-cell and spatial transcriptomics
  • Mass spectrometry techniques and applications

Jiahuai Han's recent publications reflect this diversity of interests. Notable papers include:

  • "RNA N6-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m6A-GLUT1-mTORC1 Axis and Is a Therapeutic Target," 2020, Gastroenterology
  • "Gut stem cell necroptosis by genome instability triggers bowel inflammation," 2020, Nature
  • "An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling," 2020, F1000Research
  • "RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes," 2021, Protein & Cell
  • "Editor's Note: p38 Mitogen-activated Protein Kinase Pathway Suppresses Cell Survival by Inducing Dephosphorylation of Mitogen-activated Protein/Extracellular Signal-regulated Kinase Kinase1,2," 2020, Cancer Research

The scientist collaborates frequently with several peers. Regular coauthors include Zhang-Hua Yang, Jianfeng Wu, Rongshan Yu, Chuan-Qi Zhong, and Shoufa Han.

The venues where Jiahuai Han most often publishes work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Analytical Chemistry
  • STAR Protocols
  • Science Advances
  • Cellular and Molecular Immunology

Best Publications

  • A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

    J Han;JD Lee;L Bibbs;RJ Ulevitch

  • Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine (∗)

    Joel Raingeaud;Shashi Gupta;Jeffrey Scott Rogers;Martin Dickens

  • The p38 signal transduction pathway: activation and function.

    Koh Ono;Jiahuai Han

  • Activation and signaling of the p38 MAP kinase pathway

    Tyler Zarubin;Jiahuai Han

  • RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

    Duan Wu Zhang;Jing Shao;Juan Lin;Na Zhang

  • Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

    Wan-ting He;Haoqiang Wan;Lichen Hu;Pengda Chen

  • Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms

    Benoit Dérijard;Joël Raingeaud;Tamera Barrett;I-Huan Wu

  • Identification of Lps2 as a key transducer of MyD88-independent TIR signalling.

    K. Hoebe;X. Du;P. Georgel;E. Janssen

  • Involvement of microRNA in AU-rich element-mediated mRNA instability.

    Qing Jing;Shuang Huang;Sabine Guth;Tyler Zarubin

  • Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family

    Yibin Wang;Shuang Huang;Valerie P. Sah;John Ross

  • Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)

    Yong Jiang;Canhe Chen;Zhuangjie Li;Wei Guo

  • Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation.

    J. Han;Y. Jiang;Z. Li;V. V. Kravchenko

  • Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

    Shengjia Zhang;Jiahuai Han;Mary Ann Sells;Jonathan Chernoff

  • Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

    Xin Chen;Wenjuan Li;Junming Ren;Deli Huang

  • Plasma membrane changes during programmed cell deaths

    Yingying Zhang;Xinliang Chen;Cyril Gueydan;Jiahuai Han

  • BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

    Yutaka Kato;Vladimir V. Kravchenko;Richard I. Tapping;Jiahuai Han

  • Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta.

    Yong Jiang;Hermann Gram;Ming Zhao;Liguo New

  • Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

    Xin Chen;Wan-ting He;Lichen Hu;Jingxian Li

  • MAPKK-Independent Activation of p38α Mediated by TAB1-Dependent Autophosphorylation of p38α

    Baoxue Ge;Hermann Gram;Franco Di Padova;Betty Huang

  • Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein

    Yibin Wang;Shuang Huang;Valerie P. Sah;Joan Heller Brown

Frequent Co-Authors

Sheng-Cai Lin
Sheng-Cai Lin Xiamen University
Richard J. Ulevitch
Richard J. Ulevitch Scripps Research Institute
Motoyuki Otsuka
Motoyuki Otsuka University of Tokyo
Peter S. Tobias
Peter S. Tobias Scripps Research Institute
Bruce Beutler
Bruce Beutler The University of Texas Southwestern Medical Center
Veli-Matti Kähäri
Veli-Matti Kähäri Turku University Hospital
Yibin Wang
Yibin Wang University of California, Los Angeles
Jian-Dong Li
Jian-Dong Li Georgia State University
John C. Mathison
John C. Mathison Scripps Research Institute
Roger J. Davis
Roger J. Davis University of Massachusetts Chan Medical School

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