D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 52 Citations 10,199 179 World Ranking 12034 National Ranking 885

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Cancer

Motoyuki Otsuka mainly focuses on Virology, Hepatocellular carcinoma, Cancer research, Molecular biology and Genetics. His work carried out in the field of Virology brings together such families of science as Dicer and Small interfering RNA. His work in Small interfering RNA covers topics such as Caenorhabditis elegans which are related to areas like microRNA.

His Hepatocellular carcinoma study is concerned with the field of Internal medicine as a whole. His Cancer research research incorporates themes from Regulator, Inflammation, Knockout mouse and Colitis. Motoyuki Otsuka has included themes like Apoptosis, Transcription factor, Transfection, Reporter gene and Signal transduction in his Molecular biology study.

His most cited work include:

  • Correction: Corrigendum: MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma (1047 citations)
  • Hypersusceptibility to Vesicular Stomatitis Virus Infection in Dicer1-Deficient Mice Is Due to Impaired miR24 and miR93 Expression (302 citations)
  • Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice (277 citations)

What are the main themes of his work throughout his whole career to date?

His main research concerns Cancer research, microRNA, Virology, Molecular biology and Hepatocellular carcinoma. His biological study spans a wide range of topics, including Carcinogenesis, Cancer, Pancreatic cancer and Inflammation, Immunology. His studies examine the connections between microRNA and genetics, as well as such issues in Bioinformatics, with regards to Non-coding RNA.

His research on Virology frequently connects to adjacent areas such as RNA interference. His work investigates the relationship between Molecular biology and topics such as Cell biology that intersect with problems in Tumor necrosis factor alpha and Transcription factor. His studies in Hepatocellular carcinoma integrate themes in fields like Hepatitis C and Genotype.

He most often published in these fields:

  • Cancer research (33.68%)
  • microRNA (36.32%)
  • Virology (21.58%)

What were the highlights of his more recent work (between 2016-2021)?

  • Cancer research (33.68%)
  • Carcinogenesis (20.53%)
  • microRNA (36.32%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are Cancer research, Carcinogenesis, microRNA, Virology and Hepatitis B virus. His studies deal with areas such as Autophagy, Circular RNA, KRAS, KRAS Gene Mutation and Pancreatic cancer as well as Cancer research. His Carcinogenesis study also includes fields such as

  • Epigenetics that intertwine with fields like Hepatocellular carcinoma, Molecular genetics, Liver disease, Bioinformatics and Pathogenesis,
  • Inflammation which is related to area like Dicer, Colitis, Azoxymethane and Tumor necrosis factor alpha,
  • Signal transduction, which have a strong connection to Cellular differentiation, Transcription factor, Pancreatitis and Gene.

As a part of the same scientific family, he mostly works in the field of Hepatocellular carcinoma, focusing on Gastroenterology and, on occasion, Chronic hepatitis. Motoyuki Otsuka combines subjects such as Molecular biology, Regulation of gene expression, Wnt signaling pathway and CpG Island Methylator Phenotype with his study of microRNA. His study in the fields of Viral replication under the domain of Virology overlaps with other disciplines such as cccDNA.

Between 2016 and 2021, his most popular works were:

  • CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity. (46 citations)
  • Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands. (41 citations)
  • MicroRNAs and Liver Disease (33 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Cancer

His primary areas of investigation include Carcinogenesis, Cancer research, RNA, microRNA and Hepatitis B virus. His Carcinogenesis research is multidisciplinary, incorporating elements of Proinflammatory cytokine, Molecular biology, Colitis and Dicer. His Cancer research research integrates issues from Histone H3, Histone, Demethylase, Pancreatic cancer and Downregulation and upregulation.

His Downregulation and upregulation research includes elements of Non-coding RNA, Carcinoma and Pancreatic ductal adenocarcinoma. His microRNA study integrates concerns from other disciplines, such as Tumor necrosis factor alpha, Pathogenesis, Hepatocellular carcinoma, Molecular genetics and Human genetics. His Hepatitis B virus study is associated with Virology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Correction: Corrigendum: MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma

Kentaro Kojima;Akemi Takata;Charles Vadnais;Motoyuki Otsuka.
Nature Communications (2012)

2039 Citations

Hypersusceptibility to Vesicular Stomatitis Virus Infection in Dicer1-Deficient Mice Is Due to Impaired miR24 and miR93 Expression

Motoyuki Otsuka;Qing Jing;Philippe Georgel;Liguo New.
Immunity (2007)

423 Citations

Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma

Vinod Kumar;Naoya Kato;Yuji Urabe;Atsushi Takahashi.
(2011)

385 Citations

Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice

Motoyuki Otsuka;Min Zheng;Masaaki Hayashi;Jing-Dwan Lee.
Journal of Clinical Investigation (2008)

381 Citations

Activation of intracellular signaling by hepatitis B and C viruses: C-viral core is the most potent signal inducer

Naoya Kato;Hideo Yoshida;Suzane Kioko Ono-nita;Jun Kato.
Hepatology (2000)

342 Citations

Full length cdna

Takao Isogai;Tomoyasu Sugiyama;Tetsuji Otsuki;Ai Wakamatsu.
(2002)

300 Citations

Serum metabolomics reveals γ-glutamyl dipeptides as biomarkers for discrimination among different forms of liver disease

Tomoyoshi Soga;Masahiro Sugimoto;Masashi Honma;Masayo Mori.
Journal of Hepatology (2011)

228 Citations

Interleukin-1β gene polymorphisms associated with hepatocellular carcinoma in hepatitis C virus infection

Yue Wang;Naoya Kato;Yujin Hoshida;Hideo Yoshida.
Hepatology (2003)

215 Citations

Hepatitis C virus core protein enhances p53 function through augmentation of DNA binding affinity and transcriptional ability.

Motoyuki Otsuka;Naoya Kato;Keng-Hsin Lan;Hideo Yoshida.
Journal of Biological Chemistry (2000)

206 Citations

Full-length cDNA sequences

Yuri Hio;Ryotaro Irie;Shizuko Ishii;Takao Isogai.
(2002)

191 Citations

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