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Tsuneo Ikenoue

Tsuneo Ikenoue

D-Index & Metrics

Molecular Biology

D-Index
46
Citations
12996
World Ranking
2784
National Ranking
207

Overview

Tsuneo Ikenoue is affiliated with the University of Tokyo in Japan and has contributed extensively to the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Their research outputs emphasize molecular biology, surgery, pathology, cancer research, and hepatology.

The primary focus of their work can be categorized into several main topics, including:

  • Wnt/β-catenin signaling in development and cancer
  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • Genetic factors in colorectal cancer
  • Cancer-related gene regulation
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Cancer Genomics and Diagnostics

Ikenoue has collaborated frequently with several researchers. Their most common coauthors are:

  • Kiyoshi Yamaguchi
  • Yoichi Furukawa
  • Kiyoko Takane
  • Saya Nakagawa
  • Dai Shida

The scientist's recent publications cover various topics within molecular biology and cancer research. Notable recent papers include:

  • "Axin2+ Peribiliary Glands in the Periampullary Region Generate Biliary Epithelial Stem Cells That Give Rise to Ampullary Carcinoma" (2021, Gastroenterology)
  • "Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis" (2021, Cell Death and Disease)
  • "Application of targeted nanopore sequencing for the screening and determination of structural variants in patients with Lynch syndrome" (2021, Journal of Human Genetics)
  • "Wnt/β-catenin signaling regulates amino acid metabolism through the suppression of CEBPA and FOXA1 in liver cancer cells" (2024, Communications Biology)
  • "NAFLD exacerbates cholangitis and promotes cholangiocellular carcinoma in mice" (2021, Cancer Science)

The scientist has published multiple papers in frequent venues such as:

  • Cancer Research
  • Journal of Human Genetics
  • iScience
  • Cancer Science
  • Gastroenterology

Best Publications

  • Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

    Bin Zhao;Xiaomu Wei;Weiquan Li;Ryan S. Udan;Ryan S. Udan

  • TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

    Chong Chen;Yu Liu;Runhua Liu;Tsuneo Ikenoue

  • Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

    Tsuneo Ikenoue;Ken Inoki;Qian Yang;Xiaoming Zhou

  • Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

    Qian Yang;Ken Inoki;Tsuneo Ikenoue;Kun Liang Guan

  • mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

    Ken Inoki;Hiroyuki Mori;Junying Wang;Tsukasa Suzuki

  • Functional analysis of PIK3CA gene mutations in human colorectal cancer.

    Tsuneo Ikenoue;Fumihiko Kanai;Yohko Hikiba;Toshiyuki Obata

  • Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma

    Hideaki Ijichi;Anna Chytil;Agnieszka E. Gorska;Mary E. Aakre

  • Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors.

    Tsuneo Ikenoue;Yohko Hikiba;Fumihiko Kanai;Yasuo Tanaka

  • PTEN Acetylation Modulates Its Interaction with PDZ Domain

    Tsuneo Ikenoue;Ken Inoki;Bin Zhao;Kun Liang Guan

  • Critical Role for Hypothalamic mTOR Activity in Energy Balance

    Hiroyuki Mori;Ken Inoki;Heike Münzberg;Darren Opland

  • Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression.

    Jeffrey A. Magee;Tsuneo Ikenoue;Daisuke Nakada;Jae Y. Lee

  • Homodimer of Two F-box Proteins βTrCP1 or βTrCP2 Binds to IκBα for Signal-dependent Ubiquitination

    Hiroshi Suzuki;Tomoki Chiba;Toshiaki Suzuki;Takashi Fujita

  • IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2

    Hiroshi Suzuki;Tomoki Chiba;Masato Kobayashi;Masahiro Takeuchi

  • Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer.

    Motoko Seto;Miki Ohta;Yoshinari Asaoka;Tsuneo Ikenoue

  • Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy

    Xiaoming Zhou;Tsuneo Ikenoue;Xiaowei Chen;Li Li

  • Determination of Helicobacter pylori Virulence by Simple Gene Analysis of the cag Pathogenicity Island

    Tsuneo Ikenoue;Shin Maeda;Keiji Ogura;Masao Akanuma

  • The hepatitis B virus X protein enhances AP-1 activation through interaction with Jab1.

    Y Tanaka;F Kanai;T Ichimura;K Tateishi

  • Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis

    Hayato Nakagawa;Yohko Hikiba;Yoshihiro Hirata;Joan Font-Burgada

  • p53-Independent Negative Regulation of p21/Cyclin-Dependent Kinase–Interacting Protein 1 by the Sonic Hedgehog-Glioma-Associated Oncogene 1 Pathway in Gastric Carcinoma Cells

    Miki Ohta;Keisuke Tateishi;Fumihiko Kanai;Hirotsugu Watabe

  • Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression.

    Miki Ohta;Motoko Seto;Hideaki Ijichi;Koji Miyabayashi

Frequent Co-Authors

Masao Omata
Masao Omata University of Tokyo
Takao Kawabe
Takao Kawabe University of Tokyo
Kazuhiko Koike
Kazuhiko Koike University of Tokyo
Yasushi Shiratori
Yasushi Shiratori Okayama University
Haruhiko Yoshida
Haruhiko Yoshida University of Tokyo
Harold L. Moses
Harold L. Moses Vanderbilt University
Motoyuki Otsuka
Motoyuki Otsuka University of Tokyo
Satoru Miyano
Satoru Miyano Tokyo Medical and Dental University
Makoto Miyagishi
Makoto Miyagishi National Institute of Advanced Industrial Science and Technology
Kazunari Taira
Kazunari Taira University of Tokyo

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