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Medicine

D-Index
105
Citations
38738
World Ranking
6799
National Ranking
656

Research.com Recognitions

  • 2010 - Fellow of the Royal Society of Edinburgh

Overview

Richard M. Sharpe is affiliated with the University of Edinburgh in the United Kingdom. Their research primarily spans the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Environmental Science, with an emphasis on subfields such as Health, Toxicology and Mutagenesis, Molecular Biology, Pediatrics, Perinatology and Child Health, Public Health, Environmental and Occupational Health, and Reproductive Medicine.

Their work extensively addresses topics including Effects and Risks of Endocrine Disrupting Chemicals, Sexual Differentiation and Disorders, Sex and Gender in Healthcare, Renal and Related Cancers, Sperm and Testicular Function, Reproductive Biology and Fertility, and Animal Testing and Alternatives.

Recent notable publications by Sharpe include:

  • Androgens and the masculinization programming window: human-rodent differences (2020) published in Biochemical Society Transactions
  • Endocrine disruption and male reproductive disorders: unanswered questions (2024) published in Human Reproduction
  • Location, location, location-where you are born may determine your reproductive (and more general) health (2021) published in Human Reproduction

Other works connected to their research group but authored by frequent collaborators include:

  • Estrogens and development of the rete testis, efferent ductules, epididymis and vas deferens (2020) by Rex A. Hess in Differentiation
  • Applying the adverse outcome pathway concept for assessing non-monotonic dose responses: biphasic effect of bis(2-ethylhexyl) phthalate (DEHP) on testosterone levels (2022) by Maria Chiara Astuto in Archives of Toxicology

Frequent collaborators include Rex A. Hess, Barry T. Hinton, Maria Chiara Astuto, D. Benford, and Laurent Bodin. Sharpe's research has been published across various venues with multiple papers appearing in Human Reproduction, Biochemical Society Transactions, Differentiation, Archives of Toxicology, and Andrology.

Richard M. Sharpe has been recognized as a Fellow of the Royal Society of Edinburgh since 2010, reflecting their standing within the scientific community. Their scholarly output reflects a focused engagement with reproductive health, toxicology, and molecular biology, aiming to advance understanding of endocrine disruption and male reproductive disorders as well as related health risks.

Best Publications

  • Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract

    R Sharpe;Niels E Skakkebaek

  • Male reproductive health and environmental xenoestrogens

    J Toppari;JC Larsen;P Christiansen;A Giwercman

  • Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood

    Richard M Sharpe;Chris McKinnell;Catrina Kivlin;Jane S Fisher

  • A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.

    Karel De Gendt;Johannes V. Swinnen;Philippa T. K. Saunders;Luc Schoonjans

  • Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism

    Michelle Welsh;Philippa T.K. Saunders;Mark Fisken;Hayley M. Scott

  • Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production.

    Richard M. Sharpe;Janes S. Fisher;Mike M. Millar;Susan Jobling

  • Human ‘testicular dysgenesis syndrome’: a possible model using in‐utero exposure of the rat to dibutyl phthalate

    Jane S Fisher;S Macpherson;N Marchetti;Richard M Sharpe

  • Public Health Implications of Altered Puberty Timing

    Mari S Golub;Gwen W Collman;Paul M D Foster;Carole A Kimmel

  • How strong is the evidence of a link between environmental chemicals and adverse effects on human reproductive health

    Richard M Sharpe;D Stewart Irvine

  • Immunohistochemical localization of androgen receptors in the rat testis: evidence for stage-dependent expression and regulation by androgens.

    William J. Bremner;Michael R. Millar;Richard M. Sharpe;Philippa T. K. Saunders

  • The 'oestrogen hypothesis'- where do we stand now?

    Richard M. Sharpe

  • Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects

    Richard M. Sharpe;Niels E. Skakkebaek

  • Hormones and testis development and the possible adverse effects of environmental chemicals.

    Richard M. Sharpe

  • Comparative effects of neonatal exposure of male rats to potent and weak (environmental) estrogens on spermatogenesis at puberty and the relationship to adult testis size and fertility: evidence for stimulatory effects of low estrogen levels.

    N. Atanassova;C. McKinnell;K. J. Turner;M. Walker

  • Environmental/lifestyle effects on spermatogenesis

    Richard M. Sharpe

  • Steroidogenesis in the Fetal Testis and Its Susceptibility to Disruption by Exogenous Compounds

    Hayley M. Scott;J. Ian Mason;Richard M. Sharpe

  • Expression of oestrogen receptor beta (ER beta) occurs in multiple cell types, including some germ cells, in the rat testis

    P. T. K. Saunders;J. S. Fisher;R. M. Sharpe;M. R. Millar

  • Evidence for inhibin-like activity in bovine follicular fluid.

    F. H. De Jong;R. M. Sharpe

  • Pathways of endocrine disruption during male sexual differentiation and masculinisation

    Richard M. Sharpe

  • Growth of human breast cancer cells inhibited by a luteinizing hormone-releasing hormone agonist

    W. R. Miller;W. N. Scott;R. Morris;H. M. Fraser

Frequent Co-Authors

Philippa T. K. Saunders
Philippa T. K. Saunders University of Edinburgh
Michael Millar
Michael Millar Barts Health NHS Trust
Richard A. Anderson
Richard A. Anderson University of Edinburgh
Alan S. McNeilly
Alan S. McNeilly University of Edinburgh
John P. Sumpter
John P. Sumpter Brunel University London
Jorma Toppari
Jorma Toppari University of Turku
Niels E. Skakkebæk
Niels E. Skakkebæk University of Copenhagen
Luiz R. França
Luiz R. França Universidade Federal de Minas Gerais

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