Guido Verhoeven

Overview

Best Publications

• A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.

  Karel De Gendt;Johannes V. Swinnen;Philippa T. K. Saunders;Luc Schoonjans

  914
  Citations

• Increased lipogenesis in cancer cells: new players, novel targets

  Johannes V Swinnen;Koen Brusselmans;Guido Verhoeven

  796
  Citations

• De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation

  Evelien Rysman;Koen Brusselmans;Katryn Scheys;Leen Timmermans

  718
  Citations

• Induction of Cancer Cell Apoptosis by Flavonoids Is Associated with Their Ability to Inhibit Fatty Acid Synthase Activity

  Koen Brusselmans;Ruth Vrolix;Guido Verhoeven;Johannes V. Swinnen

  588
  Citations

• Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer

  Johannes V. Swinnen;Tania Roskams;Steven Joniau;Hein Van Poppel

  429
  Citations

• Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells.

  Annelies Beckers;Sophie Organe;Leen Timmermans;Katryn Scheys

  409
  Citations

• RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells.

  Koen Brusselmans;Ellen De Schrijver;Guido Verhoeven;Johannes V. Swinnen

  395
  Citations

• RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells.

  Ellen De Schrijver;Koen Brusselmans;Walter Heyns;Guido Verhoeven

  380
  Citations

• Coordinate regulation of lipogenic gene expression by androgens: Evidence for a cascade mechanism involving sterol regulatory element binding proteins

  Johannes V. Swinnen;William Ulrix;Walter Heyns;Guido Verhoeven

  348
  Citations

• The Androgen Receptor Amino-Terminal Domain Plays a Key Role in p160 Coactivator-Stimulated Gene Transcription

  Philippe Alen;Frank Claessens;Guido Verhoeven;Wilfried Rombauts

  341
  Citations

• Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains

  Johannes V Swinnen;Paul P Van Veldhoven;Leen Timmermans;Ellen De Schrijver

  318
  Citations

• Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP.

  Johannes V. Swinnen;Murielle Esquenet;Karine Goossens;Walter Heyns

  295
  Citations

• Role of the Phosphatidylinositol 3′-Kinase/PTEN/Akt Kinase Pathway in the Overexpression of Fatty Acid Synthase in LNCaP Prostate Cancer Cells

  Tine Van de Sande;Ellen De Schrijver;Walter Heyns;Guido Verhoeven

  283
  Citations

• Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells

  Koen Brusselmans;Ellen De Schrijver;Walter Heyns;Guido Verhoeven

  280
  Citations

• Conditional Inactivation of Androgen Receptor Gene in the Nervous System: Effects on Male Behavioral and Neuroendocrine Responses

  Kalina Raskin;Karel de Gendt;Anne Duittoz;Philippe Liere

  277
  Citations

• Selective activation of the fatty acid synthesis pathway in human prostate cancer.

  Johannes V. Swinnen;Frank Vanderhoydonc;Abdelaziz A. Elgamal;Marianne Eelen

  277
  Citations

• Selective DNA binding by the androgen receptor as a mechanism for hormone-specific gene regulation.

  Frank Claessens;Guy Verrijdt;Erik Schoenmakers;Anna Haelens

  265
  Citations

• The Role of Androgens in Sertoli Cell Proliferation and Functional Maturation: Studies in Mice with Total or Sertoli Cell-Selective Ablation of the Androgen Receptor

  Karen A. L. Tan;Karel De Gendt;Nina Atanassova;Marion Walker

  258
  Citations

• Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway

  Johannes V Swinnen;Hannelore Heemers;Ludo Deboel;Fabienne Foufelle

  257
  Citations

• Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice: a study in the androgen receptor knockout mouse model.

  Katrien Venken;Karel De Gendt;Steven Boonen;Jill Ophoff

  230
  Citations