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Biology and Biochemistry

D-Index
66
Citations
15507
World Ranking
8674
National Ranking
221

Overview

Colleen C. Nelson is affiliated with the Queensland University of Technology in Australia. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with substantial focus on Molecular Biology, Cancer Research, Pulmonary and Respiratory Medicine, Oncology, and Biochemistry as subfields.

The scientist's work extensively covers topics related to prostate cancer treatment and research, cancer lipid metabolism, single-cell and spatial transcriptomics, cancer genomics and diagnostics, lipid metabolism and biosynthesis, as well as computational drug discovery methods.

Notable recent publications include:

  • Gene expression based inference of cancer drug sensitivity, 2022, Nature Communications
  • Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer, 2020, Cancer & Metabolism
  • Apocryphal FADS2 activity promotes fatty acid diversification in cancer, 2021, Cell Reports
  • Transient Sox9 Expression Facilitates Resistance to Androgen-Targeted Therapy in Prostate Cancer, 2020, Clinical Cancer Research
  • In vitro engineering of a bone metastases model allows for study of the effects of antiandrogen therapies in advanced prostate cancer, 2021, Science Advances

Frequent co-authors in their research collaborations include:

  • Anja Rockstroh
  • Melanie Lehman
  • Martin C. Sadowski
  • N Bhattacharya
  • Jennifer H. Gunter

Their research findings have been consistently published in venues such as:

  • The Prostate
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Clinical Cancer Research
  • Endocrine Related Cancer
  • eLife

Colleen C. Nelson's scientific contributions engage deeply with the molecular mechanisms underlying prostate cancer and related metabolic processes, employing advanced genomic and transcriptomic approaches. Their integration of cancer genomics with lipid metabolism studies supports a multidisciplinary approach to understanding cancer biology and treatment responses.

The research outputs indicate an emphasis on understanding drug sensitivity and therapeutic resistance, as well as the development of in vitro models that simulate metastatic environments, particularly relevant to prostate cancer progression and treatment challenges.

Best Publications

  • Androgen Levels Increase by Intratumoral De novo Steroidogenesis during Progression of Castration-Resistant Prostate Cancer

    Jennifer A. Locke;Emma S. Guns;Amy A. Lubik;Hans H. Adomat

  • Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer.

    Elahe A. Mostaghel;Stephanie T. Page;Daniel W. Lin;Ladan Fazli

  • Interaction of Nuclear Receptors with the Wnt/β-Catenin/Tcf Signaling Axis: Wnt You Like to Know?

    David J. Mulholland;David J. Mulholland;Shoukat Dedhar;Gerhard A. Coetzee;Colleen C. Nelson

  • Development and Application of a Salmonid EST Database and cDNA Microarray: Data Mining and Interspecific Hybridization Characteristics

    Matthew L. Rise;Kristian R. von Schalburg;Gordon D. Brown;Melanie A. Mawer

  • Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells

    Brent W Sutherland;Jill Kucab;Joyce Wu;Cathy Lee

  • Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development.

    Qian Wang;Qian Wang;Rae Anne Hardie;Rae Anne Hardie;Andrew J. Hoy;Michelle Van Geldermalsen;Michelle Van Geldermalsen

  • Conifer defence against insects: microarray gene expression profiling of Sitka spruce (Picea sitchensis) induced by mechanical wounding or feeding by spruce budworms (Choristoneura occidentalis) or white pine weevils (Pissodes strobi ) reveals large-scale changes of the host transcriptome

    Steven G. Ralph;Hesther Yueh;Michael Friedmann;Dana Aeschliman

  • Dysregulation of Sterol Response Element-Binding Proteins and Downstream Effectors in Prostate Cancer during Progression to Androgen Independence

    Susan L. Ettinger;Richard Sobel;Tanis G. Whitmore;Majid Akbari

  • Testosterone-repressed prostate message-2 is an antiapoptotic gene involved in progression to androgen independence in prostate cancer.

    Hideaki Miyake;Colleen Nelson;Paul S. Rennie;Martin E. Gleave

  • Cooperative interactions between androgen receptor (AR) and heat-shock protein 27 facilitate AR transcriptional activity.

    Amina Zoubeidi;Anousheh Zardan;Eliana Beraldi;Ladan Fazli

  • PTEN and GSK3β : Key regulators of progression to androgen-independent prostate cancer

    David Mulholland;David Mulholland;Shoukat Dedhar;H Wu;Colleen Nelson

  • Acquisition of chemoresistant phenotype by overexpression of the antiapoptotic gene testosterone-repressed prostate message-2 in prostate cancer xenograft models

    Hideaki Miyake;Colleen Nelson;Paul S. Rennie;Martin E. Gleave

  • Progression to Androgen Independence Is Delayed by Adjuvant Treatment with Antisense Bcl-2 Oligodeoxynucleotides after Castration in the LNCaP Prostate Tumor Model

    Martin Gleave;Anthony Tolcher;Hideaki Miyake;Colleen Nelson

  • Determinants of DNA Sequence Specificity of the Androgen, Progesterone, and Glucocorticoid Receptors: Evidence for Differential Steroid Receptor Response Elements

    Colleen C. Nelson;Stephen C. Hendy;Robert J. Shukin;Helen Cheng

  • miRDeep*: an integrated application tool for miRNA identification from RNA sequencing data

    Jiyuan An;John Lai;Melanie L. Lehman;Colleen C. Nelson

  • Fish and chips: various methodologies demonstrate utility of a 16,006-gene salmonid microarray.

    Kristian R von Schalburg;Matthew L Rise;Glenn A Cooper;Gordon D Brown

  • YB-1 is upregulated during prostate cancer tumor progression and increases P-glycoprotein activity.

    Pepita Giménez-Bonafé;Matthew N. Fedoruk;Tanis G. Whitmore;Majid Akbari

  • Increased Hsp27 after androgen ablation facilitates androgen-independent progression in prostate cancer via signal transducers and activators of transcription 3-mediated suppression of apoptosis.

    Palma Rocchi;Eliana Beraldi;Susan Ettinger;Ladan Fazli

  • The Androgen Receptor Can Promote β-Catenin Nuclear Translocation Independently of Adenomatous Polyposis Coli *

    David J. Mulholland;Helen Cheng;Kim Reid;Paul S. Rennie

  • Conifer defence against insects: microarray gene expression profiling of Sitka spruce (Picea sitchensis) induced by mechanical wounding or feeding by spruce budworms (Choristoneura occidentalis) or white pine weevils (Pissodes strobi) reveals large

    Steven Ralph;Hesther Yueh;Michael Friedmann;Dana Aeschliman

Frequent Co-Authors

Martin E. Gleave
Martin E. Gleave University of British Columbia
Elizabeth D. Williams
Elizabeth D. Williams Queensland University of Technology
Judith A. Clements
Judith A. Clements Queensland University of Technology
Pamela J. Russell
Pamela J. Russell Queensland University of Technology
Ladan Fazli
Ladan Fazli University of British Columbia
Rohan Andrew Davis
Rohan Andrew Davis Griffith University
Jyotsna Batra
Jyotsna Batra Queensland University of Technology
John E.J. Rasko
John E.J. Rasko Centenary Institute of Cancer Medicine and Cell Biology
Majid Ebrahimi Warkiani
Majid Ebrahimi Warkiani University of Technology Sydney
Amina Zoubeidi
Amina Zoubeidi University of British Columbia

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