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Molecular Biology

D-Index
78
Citations
22730
World Ranking
1077
National Ranking
26

Overview

John E.J. Rasko is affiliated with the University of Sydney in Australia. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Within these domains, they focus on subfields including Molecular Biology, Oncology, Genetics, Hematology, and Physiology.

The scientist's body of work explores several main topics, notably:

  • CAR-T cell therapy research
  • RNA Research and Splicing
  • RNA modifications and cancer
  • Virus-based gene therapy research
  • Biomedical Ethics and Regulation
  • Hemophilia Treatment and Research
  • Genomics and Chromatin Dynamics

Rasko has been published frequently in venues such as Cytotherapy, bioRxiv (Cold Spring Harbor Laboratory), Blood, Transplantation and Cellular Therapy, and Nucleic Acids Research. Their notable recent papers include:

  • "Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: a phase I, multicenter, open-label, dose-escalation study" (2020, Nature Medicine)
  • "Multiyear Factor VIII Expression after AAV Gene Transfer for Hemophilia A" (2021, New England Journal of Medicine)
  • "Long-Term Follow-Up of the First in Human Intravascular Delivery of AAV for Gene Transfer: AAV2-hFIX16 for Severe Hemophilia B" (2020, Molecular Therapy)
  • "Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance" (2020, Nature Communications)
  • "Surveying brain tumor heterogeneity by single-cell RNA-sequencing of multi-sector biopsies" (2020, National Science Review)

Frequent collaborators in Rasko's research include Charles G. Bailey, Ulf Schmitz, Dannel Yeo, Justin Wong, and Z. Velickovic.

Best Publications

  • Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

    Manno Cs;Pierce Gf;Arruda Vr;Glader B

  • CD8(+) T-cell responses to adeno-associated virus capsid in humans.

    Federico Mingozzi;Marcela V Maus;Marcela V Maus;Daniel J Hui;Denise E Sabatino

  • Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant.

    Lindsey A. George;Spencer K. Sullivan;Adam Giermasz;John E.J. Rasko;John E.J. Rasko

  • Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia

    Alexis A. Thompson;Mark C. Walters;Janet Kwiatkowski;John E.J. Rasko;John E.J. Rasko;John E.J. Rasko

  • ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

    M van Geldermalsen;M van Geldermalsen;Q Wang;Q Wang;R Nagarajah;R Nagarajah;A D Marshall;A D Marshall

  • BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma

    Dmitri I. Loukinov;Elena Pugacheva;Sergei Vatolin;Svetlana D. Pack

  • Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation

    Justin J.-L. Wong;Justin J.-L. Wong;William Ritchie;William Ritchie;Olivia A. Ebner;Matthias Selbach

  • Improved Gene Transfer Into Baboon Marrow Repopulating Cells Using Recombinant Human Fibronectin Fragment CH-296 in Combination With Interleukin-6, Stem Cell Factor, FLT-3 Ligand, and Megakaryocyte Growth and Development Factor

    Hans Peter Kiem;Hans Peter Kiem;Robert G. Andrews;Robert G. Andrews;Julia Morris;Julia Morris;Laura Peterson;Laura Peterson

  • Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development.

    Qian Wang;Qian Wang;Rae Anne Hardie;Rae Anne Hardie;Andrew J. Hoy;Michelle Van Geldermalsen;Michelle Van Geldermalsen

  • Synthetic elastin hydrogels derived from massive elastic assemblies of self-organized human protein monomers.

    Suzanne M. Mithieux;John E.J. Rasko;Anthony S. Weiss

  • Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

    Clare G Fedele;Lisa M Ooms;Miriel Ho;Jessica L Vieusseux

  • Randomized, Blinded, Placebo-Controlled Phase I Trial of Pegylated Recombinant Human Megakaryocyte Growth and Development Factor With Filgrastim After Dose-Intensive Chemotherapy in Patients With Advanced Cancer

    Russell L. Basser;John E.J. Rasko;Kerrie Clarke;Jonathan Cebon

  • Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells.

    Jeff Holst;Sarah Watson;Megan S Lord;Steven S Eamegdool

  • A human cell-surface receptor for xenotropic and polytropic murine leukemia viruses: Possible role in G protein-coupled signal transduction

    J.-L. Battini;J. E. J. Rasko;A. D. Miller

  • Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19

    Heng F Seow;Stefan Bröer;Angelika Bröer;Charles G Bailey

  • Molecular Cloning of Mouse Amino Acid Transport System B0, a Neutral Amino Acid Transporter Related to Hartnup Disorder

    Angelika Broer;Karen Klingel;Sonja Kowalczuk;John Edward Rasko

  • The RD114/simian type D retrovirus receptor is a neutral amino acid transporter

    John E J Rasko;Jean Luc Battini;Rebecca J. Gottschalk;Ilya Mazo

  • A protein complex in the brush-border membrane explains a Hartnup disorder allele

    Sonja Kowalczuk;Angelika Broer;Nadine Tietze;Jessica M. Vanslambrouck

  • Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer.

    Russell L Basser;John Ej Rasko;Kerrie Clarke;Jonathan Cebon

  • Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: a phase I, multicenter, open-label, dose-escalation study.

    Adrian J. C. Bloor;Amit Patel;James E. Griffin;Maria H. Gilleece

Frequent Co-Authors

Philippe Leboulch
Philippe Leboulch Brigham and Women's Hospital
Katherine A. High
Katherine A. High Children's Hospital of Philadelphia
Susan J. Clark
Susan J. Clark Garvan Institute of Medical Research
Colleen C. Nelson
Colleen C. Nelson Queensland University of Technology
Elliott Vichinsky
Elliott Vichinsky University of California, San Francisco
Frank J. Lovicu
Frank J. Lovicu University of Sydney
Stefan Bröer
Stefan Bröer Australian National University
Timothy P. Hughes
Timothy P. Hughes South Australian Health and Medical Research Institute
Jean-Pierre Levesque
Jean-Pierre Levesque University of Queensland
Victor V. Lobanenkov
Victor V. Lobanenkov National Institutes of Health

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