D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Immunology D-index 65 Citations 16,068 235 World Ranking 1906 National Ranking 934

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Immune system
  • Internal medicine

Roland W. Herzog mainly focuses on Immunology, Genetic enhancement, Factor IX, Immune system and Transgene. Antibody is the focus of his Immunology research. His biological study spans a wide range of topics, including Vector, Internal medicine, Partial thromboplastin time and Null allele.

While the research belongs to areas of Factor IX, Roland W. Herzog spends his time largely on the problem of Intramuscular injection, intersecting his research to questions surrounding Adenoviridae. His study in the field of Immune tolerance, Innate immune system and T cell also crosses realms of Cold storage. The concepts of his Transgene study are interwoven with issues in Molecular biology, Gene product and Virology.

His most cited work include:

  • Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector (936 citations)
  • AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B. (622 citations)
  • LONG-TERM CORRECTION OF CANINE HEMOPHILIA B BY GENE TRANSFER OF BLOOD COAGULATION FACTOR IX MEDIATED BY ADENO-ASSOCIATED VIRAL VECTOR (522 citations)

What are the main themes of his work throughout his whole career to date?

His primary scientific interests are in Immunology, Immune system, Genetic enhancement, Factor IX and Immune tolerance. His Immunology research includes themes of Genetic transfer and Adeno-associated virus. His research in Immune system intersects with topics in Cytotoxic T cell, Bioinformatics, Antigen and Cell biology.

His Genetic enhancement research integrates issues from Transgene, Virology, Vector, Coagulation and Viral vector. The various areas that Roland W. Herzog examines in his Transgene study include Molecular biology, Gene expression and Transduction. His Factor IX study combines topics in areas such as Mutation, Intramuscular injection, Gene delivery and Skeletal muscle.

He most often published in these fields:

  • Immunology (53.12%)
  • Immune system (48.05%)
  • Genetic enhancement (50.39%)

What were the highlights of his more recent work (between 2017-2020)?

  • Genetic enhancement (50.39%)
  • Immune system (48.05%)
  • Bioinformatics (12.11%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are Genetic enhancement, Immune system, Bioinformatics, Cell biology and Coagulation. His Genetic enhancement research is multidisciplinary, incorporating perspectives in Vector, Internal medicine, Oncology and Chimera. His Immune system research entails a greater understanding of Immunology.

His study on Bioinformatics also encompasses disciplines like

  • Clotting factor which is related to area like Virus,
  • MEDLINE together with Immunogenicity, Capsid and Virology. His Cell biology research incorporates elements of Adeno-associated virus, Hepatocyte, Green fluorescent protein, Innate immune system and Antigen presentation. His work in Adeno-associated virus tackles topics such as Immune tolerance which are related to areas like Genetic disorder, Factor IX and Isoantibodies.

Between 2017 and 2020, his most popular works were:

  • Update on clinical gene therapy for hemophilia (46 citations)
  • Update on clinical gene therapy for hemophilia (46 citations)
  • A Molecular Revolution in the Treatment of Hemophilia. (27 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Immune system
  • Internal medicine

His main research concerns Genetic enhancement, Immune system, Bioinformatics, Coagulation and Cell biology. His Genetic enhancement research is multidisciplinary, incorporating elements of Genetically modified organism, Hepatitis C virus, Hepatocyte, Liver disease and In vivo. His Immune system study is concerned with the larger field of Immunology.

His research integrates issues of Protein replacement therapy, Clotting factor, Anticoagulant and Small interfering RNA in his study of Bioinformatics. He combines subjects such as Dendritic cell, CD8, Cytotoxic T cell, Antigen presentation and Innate immune system with his study of Cell biology. Roland W. Herzog interconnects Vector, Hemophilias, Cell therapy and Adoptive cell transfer in the investigation of issues within Viral vector.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector

Mark A. Kay;Catherine S. Manno;Catherine S. Manno;Margaret V. Ragni;Peter J. Larson;Peter J. Larson.
Nature Genetics (2000)

1294 Citations

AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.

Catherine S. Manno;Amy J. Chew;Sylvia Hutchison;Peter J. Larson.
Blood (2003)

875 Citations

LONG-TERM CORRECTION OF CANINE HEMOPHILIA B BY GENE TRANSFER OF BLOOD COAGULATION FACTOR IX MEDIATED BY ADENO-ASSOCIATED VIRAL VECTOR

Roland W. Herzog;Edmund Y. Yang;Linda B. Couto;J. Nathan Hagstrom.
Nature Medicine (1999)

825 Citations

STABLE GENE TRANSFER AND EXPRESSION OF HUMAN BLOOD COAGULATION FACTOR IX AFTER INTRAMUSCULAR INJECTION OF RECOMBINANT ADENO-ASSOCIATED VIRUS

R W Herzog;J N Hagstrom;S H Kung;S J Tai.
Proceedings of the National Academy of Sciences of the United States of America (1997)

705 Citations

Progress and prospects: immune responses to viral vectors

Sushrusha Nayak;Roland W. Herzog.
Gene Therapy (2010)

652 Citations

Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses.

Li Zhong;Baozheng Li;Cathryn S. Mah;Lakshmanan Govindasamy.
Proceedings of the National Academy of Sciences of the United States of America (2008)

638 Citations

Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer

Federico Mingozzi;Yi-Lin Liu;Eric Dobrzynski;Antje Kaufhold.
Journal of Clinical Investigation (2003)

546 Citations

Sustained phenotypic correction of hemophilia B dogs with a factor IX null mutation by liver-directed gene therapy.

Jane D. Mount;Roland W. Herzog;D. Michael Tillson;Susan A. Goodman.
Blood (2002)

502 Citations

Long-term correction of inhibitor-prone hemophilia B dogs treated with liver-directed AAV2-mediated factor IX gene therapy.

Glenn P. Niemeyer;Glenn P. Niemeyer;Roland W. Herzog;Jane Mount;Valder R. Arruda.
Blood (2009)

341 Citations

Immune Responses to Viral Gene Therapy Vectors.

Jamie L. Shirley;Ype P. de Jong;Cox Terhorst;Roland W. Herzog.
Molecular Therapy (2020)

277 Citations

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