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Immunology

D-Index
72
Citations
20348
World Ranking
2205
National Ranking
1067

Overview

Roland W. Herzog is affiliated with the University of Florida in the United States. Their research spans multiple facets of biochemistry, genetics, molecular biology, and medicine, with a particular focus on applied gene therapy and immunological responses in genetic engineering contexts.

The scientist has contributed extensively to several main fields of study, including:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Their research can be further categorized into several specific subfields:

  • Molecular Biology
  • Genetics
  • Oncology
  • Hematology
  • Infectious Diseases

Roland W. Herzog's main research topics include:

  • Virus-based gene therapy research
  • CRISPR and Genetic Engineering
  • CAR-T cell therapy research
  • Hemophilia Treatment and Research
  • RNA Interference and Gene Delivery
  • Viral Infectious Diseases and Gene Expression in Insects
  • Viral gastroenteritis research and epidemiology

Their work is documented in various leading scientific journals, with frequent publications in these venues:

  • Molecular Therapy
  • arXiv (Cornell University)
  • Blood
  • Molecular Therapy - Methods & Clinical Development
  • Human Gene Therapy

Some of the notable recent papers authored or co-authored by Roland W. Herzog include:

  • Immune Responses to Viral Gene Therapy Vectors, 2020, Molecular Therapy
  • Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models, 2021, Nature Communications
  • Thrombotic microangiopathy following systemic AAV administration is dependent on anti-capsid antibodies, 2023, Journal of Clinical Investigation
  • Role of orally induced regulatory T cells in immunotherapy and tolerance, 2020, Cellular Immunology
  • Effect of CpG Depletion of Vector Genome on CD8+ T Cell Responses in AAV Gene Therapy, 2021, Frontiers in Immunology

Roland W. Herzog has frequently collaborated with several co-authors, including:

  • Sandeep Kumar
  • Moanaro Biswas
  • Thaís B. Bertolini
  • Weidong Xiao
  • Ype P. de Jong

Best Publications

  • Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector

    Mark A. Kay;Catherine S. Manno;Catherine S. Manno;Margaret V. Ragni;Peter J. Larson;Peter J. Larson

  • AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.

    Catherine S. Manno;Amy J. Chew;Sylvia Hutchison;Peter J. Larson

  • LONG-TERM CORRECTION OF CANINE HEMOPHILIA B BY GENE TRANSFER OF BLOOD COAGULATION FACTOR IX MEDIATED BY ADENO-ASSOCIATED VIRAL VECTOR

    Roland W. Herzog;Edmund Y. Yang;Linda B. Couto;J. Nathan Hagstrom

  • Progress and prospects: immune responses to viral vectors

    Sushrusha Nayak;Roland W. Herzog

  • Immune Responses to Viral Gene Therapy Vectors.

    Jamie L. Shirley;Ype P. de Jong;Cox Terhorst;Roland W. Herzog

  • STABLE GENE TRANSFER AND EXPRESSION OF HUMAN BLOOD COAGULATION FACTOR IX AFTER INTRAMUSCULAR INJECTION OF RECOMBINANT ADENO-ASSOCIATED VIRUS

    R W Herzog;J N Hagstrom;S H Kung;S J Tai

  • Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses.

    Li Zhong;Baozheng Li;Cathryn S. Mah;Lakshmanan Govindasamy

  • Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer

    Federico Mingozzi;Yi-Lin Liu;Eric Dobrzynski;Antje Kaufhold

  • Sustained phenotypic correction of hemophilia B dogs with a factor IX null mutation by liver-directed gene therapy.

    Jane D. Mount;Roland W. Herzog;D. Michael Tillson;Susan A. Goodman

  • Long-term correction of inhibitor-prone hemophilia B dogs treated with liver-directed AAV2-mediated factor IX gene therapy.

    Glenn P. Niemeyer;Glenn P. Niemeyer;Roland W. Herzog;Jane Mount;Valder R. Arruda

  • Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression

    Li Zhong;Baozheng Li;Giridhararao Jayandharan;Cathryn S. Mah

  • Clinical development of gene therapy: results and lessons from recent successes.

    Sandeep Rp Kumar;David M Markusic;Moanaro Biswas;Katherine A High

  • Muscle-Directed Gene Transfer and Transient Immune Suppression Result in Sustained Partial Correction of Canine Hemophilia B Caused by a Null Mutation

    Roland W. Herzog;Jane D. Mount;Valder R. Arruda;Katherine A. High

  • The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9–dependent innate immune responses in the liver

    Ashley T. Martino;Masataka Suzuki;David M. Markusic;Irene Zolotukhin

  • Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transfer.

    Ou W. Cao;Eric Dobrzynski;Lixin Wang;Sushrusha Nayak

  • Adeno-Associated Viral Vector-Mediated Gene Transfer of Human Blood Coagulation Factor IX Into Mouse Liver

    Hiroyuki Nakai;Roland W. Herzog;J. Nathan Hagstrom;Johannes Walter

  • Treatment of human disease by adeno-associated viral gene transfer

    Kenneth H. Warrington;Roland W. Herzog

  • Lack of germline transmission of vector sequences following systemic administration of recombinant AAV-2 vector in males.

    Valder R. Arruda;Paul A. Fields;Ross Milner;Luanne Wainwright

  • Influence of vector dose on factor IX-specific T and B cell responses in muscle-directed gene therapy

    Roland W. Herzog;Paul A. Fields;Valder R. Arruda;Jeff O. Brubaker

  • Safety and efficacy of factor IX gene transfer to skeletal muscle in murine and canine hemophilia B models by adeno-associated viral vector serotype 1

    Valder R. Arruda;Joerg Schuettrumpf;Roland W. Herzog;Timothy C. Nichols

Frequent Co-Authors

Katherine A. High
Katherine A. High Children's Hospital of Philadelphia
Cox Terhorst
Cox Terhorst Beth Israel Deaconess Medical Center
Barry J. Byrne
Barry J. Byrne University of Florida
Henry Daniell
Henry Daniell University of Pennsylvania
Valder R. Arruda
Valder R. Arruda University of Pennsylvania
Federico Mingozzi
Federico Mingozzi Children's Hospital of Philadelphia
Arun Srivastava
Arun Srivastava University of Florida
Sergei Zolotukhin
Sergei Zolotukhin University of Florida
Mark A. Kay
Mark A. Kay Stanford University

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