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Thierry VandenDriessche

Thierry VandenDriessche

D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
13337
World Ranking
10831
National Ranking
195

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Cancer

Thierry VandenDriessche mainly investigates Genetic enhancement, Virology, Molecular biology, Immunology and Viral vector. Thierry VandenDriessche has researched Genetic enhancement in several fields, including Vector, In vivo and Cell biology. His studies deal with areas such as Insertional mutagenesis, Transgene and Mutation as well as Virology.

The Molecular biology study combines topics in areas such as RNA, Gene, Mutant, Green fluorescent protein and Bone marrow. His Immunology study incorporates themes from Severe combined immunodeficiency and Gene delivery. His research combines Ex vivo and Viral vector.

His most cited work include:

  • Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions (1431 citations)
  • Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates (609 citations)
  • Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism (401 citations)

What are the main themes of his work throughout his whole career to date?

His primary scientific interests are in Genetic enhancement, Immunology, Viral vector, Virology and Factor IX. His work investigates the relationship between Genetic enhancement and topics such as Cancer research that intersect with problems in Transfection. His Immunology research is multidisciplinary, incorporating perspectives in Clinical trial and In vivo.

His research in Viral vector intersects with topics in Molecular biology, Computational biology, Gene expression and Transduction. His Factor IX study results in a more complete grasp of Internal medicine. Thierry VandenDriessche interconnects Clotting factor and Stem cell in the investigation of issues within Gene delivery.

He most often published in these fields:

  • Genetic enhancement (78.71%)
  • Immunology (37.75%)
  • Viral vector (38.15%)

What were the highlights of his more recent work (between 2016-2021)?

  • Genetic enhancement (78.71%)
  • Viral vector (38.15%)
  • Gene (21.69%)

In recent papers he was focusing on the following fields of study:

Genetic enhancement, Viral vector, Gene, Bioinformatics and Factor IX are his primary areas of study. His Genetic enhancement study combines topics from a wide range of disciplines, such as Vector, Adeno-associated virus, Computational biology and Transgene. His research integrates issues of Promoter and Gene expression in his study of Transgene.

His Gene study improves the overall literature in Genetics. His Factor IX research incorporates themes from Vector, Antigen, Spleen, Hemophilias and Knockout mouse. His work carried out in the field of Transposable element brings together such families of science as Cellular differentiation and Induced pluripotent stem cell.

Between 2016 and 2021, his most popular works were:

  • Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells. (38 citations)
  • Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells. (38 citations)
  • A Novel Platform for Immune Tolerance Induction in Hemophilia A Mice (36 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Cancer

Thierry VandenDriessche mainly focuses on Viral vector, Genetic enhancement, Muscle disorder, Gene expression and Transgene. Thierry VandenDriessche has included themes like Bioinformatics, Transposable element, Transposase and Virology in his Viral vector study. His Transposable element study integrates concerns from other disciplines, such as Transfection and Induced pluripotent stem cell.

His study explores the link between Genetic enhancement and topics such as Computational biology that cross with problems in Cellular differentiation. His biological study spans a wide range of topics, including MBNL1, CRISPR, Follistatin, Promoter and Transduction. His Gene expression research is multidisciplinary, relying on both Haematopoiesis and Immune system, Antibody, Immune tolerance, Immunology.

Best Publications

  • Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions

    Peter Carmeliet;Lieve Moons;Aernout Luttun;Valeria Vincenti

  • Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

    Lajos Mátés;Marinee K L Chuah;Eyayu Belay;Boris Jerchow

  • Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

    Julián Aragonés;Martin Schneider;Martin Schneider;Martin Schneider;Katie Van Geyte;Katie Van Geyte;Peter Fraisl;Peter Fraisl

  • Recent Advances in Lentiviral Vector Development and Applications

    Janka Mátrai;Marinee K L Chuah;Thierry VandenDriessche

  • Lentiviral vectors containing the human immunodeficiency virus type-1 central polypurine tract can efficiently transduce nondividing hepatocytes and antigen-presenting cells in vivo

    Thierry VandenDriessche;Lieven Thorrez;Luigi Naldini;Antonia Follenzi

  • Nanoparticles for the delivery of genes and drugs to human hepatocytes

    Tadanori Yamada;Yasushi Iwasaki;Hiroko Tada;Hidehiko Iwabuki

  • Comparative analysis of transposable element vector systems in human cells

    Ivana Grabundzija;Markus Irgang;Lajos Mátés;Eyayu Belay

  • Long-term expression of human coagulation factor VIII and correction of hemophilia A after in vivo retroviral gene transfer in factor VIII-deficient mice

    Thierry VandenDriessche;Veerle Vanslembrouck;Inge Goovaerts;Hans Zwinnen

  • Efficacy and safety of adeno-associated viral vectors based on serotype 8 and 9 vs. lentiviral vectors for hemophilia B gene therapy.

    T. Vandendriessche;L. Thorrez;A. Acosta-Sanchez;I. Petrus

  • Codon optimization of human factor VIII cDNAs leads to high-level expression

    Natalie J. Ward;Suzanne M. K. Buckley;Simon N. Waddington;Thierry VandenDriessche;Thierry VandenDriessche

  • Challenges with advanced therapy medicinal products and how to meet them

    Christian K. Schneider;Paula Salmikangas;Bernd Jilma;Bruno Flamion

  • Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors

    Marinee K L Chuah;Gudrun Schiedner;Lieven Thorrez;Brian Brown

  • Gene therapy for cardiovascular disease: advances in vector development, targeting, and delivery for clinical translation

    Melvin Y. Rincon;Thierry VandenDriessche;Thierry VandenDriessche;Marinee K. Chuah;Marinee K. Chuah

  • Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells

    Thierry VandenDriessche;Zoltán Ivics;Zsuzsanna Izsvák;Marinee K. L. Chuah

  • Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants

    Jonas Weinmann;Sabrina Weis;Josefine Sippel;Warut Tulalamba

  • Long-term persistence of human bone marrow stromal cells transduced with factor VIII-retroviral vectors and transient production of therapeutic levels of human factor VIII in nonmyeloablated immunodeficient mice

    Marinee K.L. Chuah;An Van Damme;Hans Zwinnen;Inge Goovaerts

  • Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk

    Janka Mátrai;Alessio Cantore;Cynthia C. Bartholomae;Andrea Annoni

  • Differential Effects of Progenitor Cell Populations on Left Ventricular Remodeling and Myocardial Neovascularization After Myocardial Infarction

    Christophe Dubois;Xiaoshun Liu;Piet Claus;Glenn Marsboom

  • Efficient Lentiviral Transduction and Improved Engraftment of Human Bone Marrow Mesenchymal Cells

    An Van Damme;Lieven Thorrez;Ling Ma;Herman Vandenburgh;Herman Vandenburgh

  • Recent Advances in Lentiviral Vector Development and Applications (vol 18, pg 477, 2010)

    Janka Matrai;Marinee Chuah;Thierry Vandendriessche

Frequent Co-Authors

Marinee Chuah
Marinee Chuah KU Leuven
Desire Collen
Desire Collen KU Leuven
Luigi Naldini
Luigi Naldini Vita-Salute San Raffaele University
Zsuzsanna Izsvák
Zsuzsanna Izsvák Max Delbrück Center for Molecular Medicine
David Lillicrap
David Lillicrap Queen's University
Herman H. Vandenburgh
Herman H. Vandenburgh Brown University
George Dickson
George Dickson Royal Holloway University of London
Eugenio Montini
Eugenio Montini IRCCS Ospedale San Raffaele

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