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Molecular Biology

D-Index
67
Citations
15396
World Ranking
1575
National Ranking
123

Overview

George Dickson is affiliated with Royal Holloway University of London in the United Kingdom. Their research focuses primarily on the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these areas, their work covers subfields such as Molecular Biology, Genetics, Cardiology and Cardiovascular Medicine, Neurology, and Rehabilitation.

The scientist's research topics emphasize Muscle Physiology and Disorders, Neurogenetic and Muscular Disorders Research, Virus-based gene therapy research, Cardiomyopathy and Myosin Studies, RNA Research and Splicing, Neurofibromatosis and Schwannoma Cases, and Neuroblastoma Research and Treatments.

Recent peer-reviewed papers include:

  • Increased dystrophin production with golodirsen in patients with Duchenne muscular dystrophy (2020, Neurology)
  • Gene Therapy for Duchenne Muscular Dystrophy (2021, Journal of Neuromuscular Diseases)
  • Long-Term Safety and Efficacy Data of Golodirsen in Ambulatory Patients with Duchenne Muscular Dystrophy Amenable to Exon 53 Skipping: A First-in-human, Multicenter, Two-Part, Open-Label, Phase 1/2 Trial (2021, Nucleic Acid Therapeutics)
  • Myostatin inhibition in combination with antisense oligonucleotide therapy improves outcomes in spinal muscular atrophy (2020, Journal of Cachexia Sarcopenia and Muscle)
  • RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways (2021, Nature Communications)

George Dickson has published frequently in specialized venues including Molecular Therapy - Nucleic Acids, Nucleic Acid Therapeutics, Human Gene Therapy, Neurology, and Journal of Neuromuscular Diseases.

Collaborative work is evident through frequent co-authors such as Linda Popplewell, Alberto Malerba, Ngoc Lu-Nguyen, Jennifer E. Morgan, and Francesco Muntoni, indicating active partnerships in research.

Best Publications

  • Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study.

    Sebahattin Cirak;Virginia Arechavala-Gomeza;Michela Guglieri;Lucy Feng

  • Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study

    Maria Kinali;Maria Kinali;Virginia Arechavala-Gomeza;Lucy Feng;Sebahattin Cirak

  • Human dystrophin expression in mdx mice after intramuscular injection of dna constructs

    Gyula Acsadi;George Dickson;Donald R. Love;Agnes Jani

  • An autosomal transcript in skeletal muscle with homology to dystrophin.

    Donald R. Love;Diane F. Hill;George Dickson;Nigel K. Spurr

  • Modification of splicing in the dystrophin gene in cultured Mdx muscle cells by antisense oligoribonucleotides

    Matthew G. Dunckley;Muthiah Manoharan;Pierre Villiet;Ian C. Eperon

  • Localization of the DMDL gene-encoded dystrophin-related protein using a panel of nineteen monoclonal antibodies: presence at neuromuscular junctions, in the sarcolemma of dystrophic skeletal muscle, in vascular and other smooth muscles, and in proliferating brain cell lines.

    T M Nguyen;J M Ellis;D R Love;K E Davies

  • A threshold effect of the major isoforms of NCAM on neurite outgrowth.

    Doherty P;Fruns M;Seaton P;Dickson G

  • Alternative splicing generates a secreted form of N-CAM in muscle and brain.

    Hilary J. Gower;C.Howard Barton;Vicki L. Elsom;Joanne Thompson

  • Increased dystrophin production with golodirsen in patients with Duchenne muscular dystrophy.

    Diane E. Frank;Frederick J. Schnell;Cody Akana;Saleh H. El-Husayni

  • Human muscle neural cell adhesion molecule (N-CAM): Identification of a muscle-specific sequence in the extracellular domain

    George Dickson;Hilary J. Gower;C.Howard Barton;Howard M. Prentice

  • Comparative analysis of antisense oligonucleotide sequences for targeted skipping of exon 51 during dystrophin pre-mRNA splicing in human muscle

    V. Arechavala-Gomeza;I.R. Graham;L.J. Popplewell;Abbie Adams

  • Current status of pharmaceutical and genetic therapeutic approaches to treat DMD.

    Christophe Pichavant;Annemieke Aartsma-Rus;Paula R Clemens;Kay E Davies

  • Long-term microdystrophin gene therapy is effective in a canine model of Duchenne muscular dystrophy.

    Caroline Le Guiner;Laurent Servais;Marie Montus;Thibaut Larcher

  • Phase I study of dystrophin plasmid-based gene therapy in Duchenne/Becker muscular dystrophy.

    Norma B. Romero;Serge Braun;Olivier Benveniste

  • Expression of human full-length and minidystrophin in transgenic mdx mice: implications for gene therapy of Duchenne muscular dystrophy

    Dominic J. Wells;Kim E. Wells;Emmanuel A. Asante;Gaynor Turner

  • Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1

    Adel Benlahrech;Julian Harris;Andrea Meiser;Timos Papagatsias

  • Enhanced myogenesis in NCAM-transfected mouse myoblasts.

    Dickson G;Peck D;Moore Se;Barton Ch

  • Poly(A) binding protein nuclear 1 levels affect alternative polyadenylation.

    Eleonora de Klerk;Andrea Venema;S. Yahya Anvar;Jelle J. Goeman

  • Direct retroviral-mediated transfer of a dystrophin minigene into mdx mouse muscle in vivo

    Matthew G. Dunckley;Dominic J. Wells;Frank S. Walsh;George Dickson

  • Neural cell adhesion molecule (NCAM) is the antigen recognized by monoclonal antibodies of similar specificity in small-cell lung carcinoma and neuroblastoma

    K. Patel;S. E. Moore;G. Dickson;R. J. Rossell

Frequent Co-Authors

Frank S. Walsh
Frank S. Walsh Wolfson Centre for Age-Related Diseases
Dominic J. Wells
Dominic J. Wells Royal Veterinary College
Francesco Muntoni
Francesco Muntoni University College London
Vincent Mouly
Vincent Mouly Université Paris Cité
Jennifer E. Morgan
Jennifer E. Morgan University College London
Thierry VandenDriessche
Thierry VandenDriessche Vrije Universiteit Brussel
Philippe Moullier
Philippe Moullier University of Nantes
Kay E. Davies
Kay E. Davies University of Oxford
Donald R. Love
Donald R. Love Auckland City Hospital
Marinee Chuah
Marinee Chuah KU Leuven

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