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Philippe Moullier

Philippe Moullier

University of Nantes
France

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Enzyme

Philippe Moullier mainly investigates Genetic enhancement, Immunology, Virology, Vector and Adeno-associated virus. The study incorporates disciplines such as Transgene, Viral vector and Transduction in addition to Genetic enhancement. His research integrates issues of Adenoviridae, Systemic administration, Pharmacology and Pathology in his study of Immunology.

The concepts of his Virology study are interwoven with issues in Genetic transfer and Recombinant DNA. His Recombinant DNA study combines topics in areas such as Titer, Molecular biology and Cell biology. His Vector research includes elements of Virus, Immunosuppression and Regulation of gene expression.

His most cited work include:

  • Intravenous Administration of Self-complementary AAV9 Enables Transgene Delivery to Adult Motor Neurons (407 citations)
  • Intravenous Administration of Self-complementary AAV9 Enables Transgene Delivery to Adult Motor Neurons (407 citations)
  • Factors influencing recombinant adeno-associated virus production. (240 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Genetic enhancement, Molecular biology, Virology, Recombinant DNA and Transgene. The various areas that Philippe Moullier examines in his Genetic enhancement study include Vector, Duchenne muscular dystrophy, Immunology and Pathology. His Molecular biology study integrates concerns from other disciplines, such as Cell culture, Viral replication, Complementary DNA, Viral vector and Polymerase chain reaction.

His work carried out in the field of Virology brings together such families of science as Gene, Transfection, Transduction and Adeno-associated virus. In his study, Secretion is strongly linked to In vivo, which falls under the umbrella field of Recombinant DNA. His work deals with themes such as Regulation of gene expression, Gene expression, Transactivation and Retina, which intersect with Transgene.

He most often published in these fields:

  • Genetic enhancement (44.12%)
  • Molecular biology (35.71%)
  • Virology (34.45%)

What were the highlights of his more recent work (between 2014-2021)?

  • Genetic enhancement (44.12%)
  • Vector (21.43%)
  • Duchenne muscular dystrophy (8.40%)

In recent papers he was focusing on the following fields of study:

Genetic enhancement, Vector, Duchenne muscular dystrophy, Virus and Molecular biology are his primary areas of study. His work carried out in the field of Genetic enhancement brings together such families of science as Transgene, Bioinformatics, Virology, Viral vector and DNA sequencing. His Transgene study incorporates themes from Phenotype and Immune system.

His study on Vector is covered under Recombinant DNA. His Virus study integrates concerns from other disciplines, such as Adeno-associated virus and Transduction. His Molecular biology research incorporates elements of Natural killer T cell, T cell, Interleukin 21 and CD8.

Between 2014 and 2021, his most popular works were:

  • Long-term microdystrophin gene therapy is effective in a canine model of Duchenne muscular dystrophy. (101 citations)
  • Long-term microdystrophin gene therapy is effective in a canine model of Duchenne muscular dystrophy. (101 citations)
  • Safety and Long-Term Efficacy of AAV4 Gene Therapy in Patients with RPE65 Leber Congenital Amaurosis. (47 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Enzyme

Philippe Moullier focuses on Genetic enhancement, Vector, Virology, Genome and Real-time polymerase chain reaction. The various areas that he examines in his Genetic enhancement study include Retinal degeneration, Neuromuscular disease, Pathology, Dystrophin and ITGA7. His research investigates the link between Vector and topics such as Titer that cross with problems in Plasmid and Computational biology.

His Virology research is multidisciplinary, incorporating elements of Adeno-associated virus, Viral vector and DNA, DNA sequencing. His work in Genome is not limited to one particular discipline; it also encompasses Recombinant DNA. Philippe Moullier has included themes like In vivo and Plasmapheresis in his Virus study.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Intravenous Administration of Self-complementary AAV9 Enables Transgene Delivery to Adult Motor Neurons

Sandra Duque;Béatrice Joussemet;Christel Riviere;Thibaut Marais;Thibaut Marais.
Molecular Therapy (2009)

542 Citations

Factors influencing recombinant adeno-associated virus production.

Anna Salvetti;Soizic Orève;Gilliane Chadeuf;David Favre.
Human Gene Therapy (1998)

367 Citations

Correction of lysosomal storage in the liver and spleen of MPS VII mice by implantation of genetically modified skin fibroblasts.

Philippe Moullier;Delphine Bohl;Jean-Michel Heard;Olivier Danos.
Nature Genetics (1993)

272 Citations

Recombinant adeno-associated virus serotype 4 mediates unique and exclusive long-term transduction of retinal pigmented epithelium in rat, dog, and nonhuman primate after subretinal delivery.

Michel Weber;Joseph Rabinowitz;Nathalie Provost;Hervé Conrath.
Molecular Therapy (2003)

263 Citations

Characterization of novel safe lentiviral vectors derived from simian immunodeficiency virus (SIVmac251) that efficiently transduce mature human dendritic cells

D Nègre;P E Mangeot;G Duisit;S Blanchard.
Gene Therapy (2000)

251 Citations

Restoration of vision in RPE65-deficient Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented epithelium

G Le Meur;K Stieger;A J Smith;M Weber.
Gene Therapy (2007)

231 Citations

Control of erythropoietin delivery by doxycycline in mice after intramuscular injection of adeno-associated vector

Delphine Bohl;Anna Salvetti;Philippe Moullier;Jean Michel Heard.
Blood (1998)

205 Citations

Composition for the in vivo production of therapeutic products

Beuzard Yves;Danos Olivier;Descamps Vincent;Heard Jean-Michel.
(1994)

203 Citations

Adeno-Associated Virus Vector Genomes Persist as Episomal Chromatin in Primate Muscle

Magalie Penaud-Budloo;Caroline Le Guiner;Ali Nowrouzi;Alice Toromanoff.
Journal of Virology (2008)

197 Citations

Lack of an Immune Response against the Tetracycline-Dependent Transactivator Correlates with Long-Term Doxycycline-Regulated Transgene Expression in Nonhuman Primates after Intramuscular Injection of Recombinant Adeno-Associated Virus

David Favre;Véronique Blouin;Nathalie Provost;Radec Spisek.
Journal of Virology (2002)

181 Citations

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