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Philippe Moullier

Philippe Moullier

D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
10060
World Ranking
11602
National Ranking
419

Overview

Philippe Moullier is affiliated with the University of Nantes in France and has contributed extensively to the field of virus-based gene therapy research. Their work spans multiple areas including genetics, molecular biology, and medicine, with a particular focus on RNA interference, gene delivery, and muscle physiology and disorders.

Their main research topics include:

  • Virus-based gene therapy research
  • RNA Interference and Gene Delivery
  • CAR-T cell therapy research
  • Muscle Physiology and Disorders
  • Viral Infectious Diseases and Gene Expression in Insects
  • Viral Infections and Immunology Research
  • Retinal Development and Disorders

Moullier's significant publication venues feature prominently in molecular therapy and immunology, including:

  • Molecular Therapy - Methods & Clinical Development
  • UNC Libraries
  • Scientific Reports
  • Frontiers in Immunology
  • Gene Therapy

Examples of recent scholarly publications by Moullier include:

  • "Intra-CSF AAV9 and AAVrh10 Administration in Nonhuman Primates: Promising Routes and Vectors for Which Neurological Diseases?" (2020) in Molecular Therapy - Methods & Clinical Development
  • "Capsid-specific removal of circulating antibodies to adeno-associated virus vectors" (2020) in Scientific Reports
  • "Tetramer-Based Enrichment of Preexisting Anti-AAV8 CD8+ T Cells in Human Donors Allows the Detection of a TEMRA Subpopulation" (2020) in Frontiers in Immunology
  • "Evaluation of the dystrophin carboxy-terminal domain for micro-dystrophin gene therapy in cardiac and skeletal muscles in the DMDmdx rat model" (2022) in Gene Therapy
  • "Evaluation of an AAV9-mini-dystrophin gene therapy candidate in a rat model of Duchenne muscular dystrophy" (2023) in Molecular Therapy - Methods & Clinical Development

Moullier frequently collaborates with several researchers, with multiple co-authorships documented with:

  • Oumeya Adjali
  • Caroline Le Guiner
  • Mickaël Guilbaud
  • Thibaut Larcher
  • Jack-Yves Deschamps

Their research contributions involve intersections of genetics, epidemiology, oncology, and cardiology, reflecting a multidisciplinary approach. The scientist's studies also cover various subfields such as genetics and molecular biology, further grounding their work in fundamental biological sciences while addressing disease-related applications.

Best Publications

  • Intravenous Administration of Self-complementary AAV9 Enables Transgene Delivery to Adult Motor Neurons

    Sandra Duque;Béatrice Joussemet;Christel Riviere;Thibaut Marais;Thibaut Marais

  • Factors influencing recombinant adeno-associated virus production.

    Anna Salvetti;Soizic Orève;Gilliane Chadeuf;David Favre

  • Adeno-Associated Virus Vector Genomes Persist as Episomal Chromatin in Primate Muscle

    Magalie Penaud-Budloo;Caroline Le Guiner;Ali Nowrouzi;Alice Toromanoff

  • Recombinant adeno-associated virus serotype 4 mediates unique and exclusive long-term transduction of retinal pigmented epithelium in rat, dog, and nonhuman primate after subretinal delivery.

    Michel Weber;Joseph Rabinowitz;Nathalie Provost;Hervé Conrath

  • Correction of lysosomal storage in the liver and spleen of MPS VII mice by implantation of genetically modified skin fibroblasts.

    Philippe Moullier;Delphine Bohl;Jean-Michel Heard;Olivier Danos

  • Characterization of novel safe lentiviral vectors derived from simian immunodeficiency virus (SIVmac251) that efficiently transduce mature human dendritic cells

    D Nègre;P E Mangeot;G Duisit;S Blanchard

  • Restoration of vision in RPE65-deficient Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented epithelium

    G Le Meur;K Stieger;A J Smith;M Weber

  • Long-term microdystrophin gene therapy is effective in a canine model of Duchenne muscular dystrophy.

    Caroline Le Guiner;Laurent Servais;Marie Montus;Thibaut Larcher

  • A 10 Patient Case Report on the Impact of Plasmapheresis Upon Neutralizing Factors Against Adeno-associated Virus (AAV) Types 1, 2, 6, and 8

    Virginie Monteilhet;Samir Saheb;Sylvie Boutin;Christian Leborgne

  • Control of erythropoietin delivery by doxycycline in mice after intramuscular injection of adeno-associated vector

    Delphine Bohl;Anna Salvetti;Philippe Moullier;Jean Michel Heard

  • Lack of an Immune Response against the Tetracycline-Dependent Transactivator Correlates with Long-Term Doxycycline-Regulated Transgene Expression in Nonhuman Primates after Intramuscular Injection of Recombinant Adeno-Associated Virus

    David Favre;Véronique Blouin;Nathalie Provost;Radec Spisek

  • Gene therapy prolongs survival and restores function in murine and canine models of myotubular myopathy

    Martin K. Childers;Romain Joubert;Karine Poulard;Christelle Moal

  • A versatile and scalable two-step ion-exchange chromatography process for the purification of recombinant adeno-associated virus serotypes-2 and -5.

    Nicole Brument;Robert Morenweiser;Véronique Blouin;Estelle Toublanc

  • In vivo gene regulation using tetracycline-regulatable systems.

    Knut Stieger;Brahim Belbellaa;Caroline Le Guiner;Philippe Moullier

  • Autoimmune anemia in macaques following erythropoietin gene therapy

    Pierre Chenuaud;Thibaut Larcher;Joseph E. Rabinowitz;Nathalie Provost

  • Safe, efficient, and reproducible gene therapy of the brain in the dog models of Sanfilippo and Hurler syndromes.

    N Matthew Ellinwood;Jérôme Ausseil;Jérôme Ausseil;Nathalie Desmaris;Nathalie Desmaris;Stéphanie Bigou;Stéphanie Bigou

  • Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material.

    Martin Lock;Susan McGorray;Alberto Auricchio;Eduard Ayuso

  • Immediate and long-term safety of recombinant adeno-associated virus injection into the nonhuman primate muscle.

    David Favre;Nathalie Provost;Véronique Blouin;Gilles Blancho

  • Forelimb Treatment in a Large Cohort of Dystrophic Dogs Supports Delivery of a Recombinant AAV for Exon Skipping in Duchenne Patients

    Caroline Le Guiner;Marie Montus;Laurent Servais;Yan Cherel

  • Retroviral-mediated gene transfer corrects very-long-chain fatty acid metabolism in adrenoleukodystrophy fibroblasts.

    N Cartier;J Lopez;P Moullier;F Rocchiccioli

Frequent Co-Authors

Olivier Danos
Olivier Danos REGENXBIO Inc.
Thomas Voit
Thomas Voit University College London
Ignacio Anegon
Ignacio Anegon University of Nantes
Nadia Naffakh
Nadia Naffakh Institut Pasteur
Fulvio Mavilio
Fulvio Mavilio University of Modena and Reggio Emilia
George Dickson
George Dickson Royal Holloway University of London
Maria-Cristina Cuturi
Maria-Cristina Cuturi University of Nantes
Michel Perricaudet
Michel Perricaudet Institut Gustave Roussy
François-Loïc Cosset
François-Loïc Cosset Claude Bernard University Lyon 1
Alan H. Beggs
Alan H. Beggs Harvard Medical School

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