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Best Scientists
2025
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Biology and Biochemistry
USA
2026

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Best Scientists

D-Index
181
Citations
109451
World Ranking
602
National Ranking
378

Biology and Biochemistry

D-Index
183
Citations
111574
World Ranking
64
National Ranking
53

Medicine

D-Index
184
Citations
112274
World Ranking
317
National Ranking
201

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award

Overview

James M. Wilson is affiliated with the University of Pennsylvania in the United States. Their research spans biochemistry, genetics, and molecular biology, with a significant focus on medicine. The main areas of study include molecular biology, genetics, oncology, infectious diseases, and surgery.

The scientist's work centers on several key topics: virus-based gene therapy research, CRISPR and genetic engineering, RNA interference and gene delivery, CAR-T cell therapy research, SARS-CoV-2 and COVID-19 research, viral gastroenteritis research and epidemiology, and viral infectious diseases and gene expression in insects.

James M. Wilson has frequently published in several journals and venues, including:

  • Human Gene Therapy
  • Molecular Therapy - Methods & Clinical Development
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Therapy
  • British Journal of Surgery

The researcher has collaborated regularly with a number of coauthors, including:

  • Jenny A. Greig
  • Peter Bell
  • Elizabeth L. Buza
  • Christian Hinderer
  • Cecilia Dyer

Among their recent papers are:

  • "Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device" (2021, Nano Letters)
  • "Antibodies against endogenous retroviruses promote lung cancer immunotherapy" (2023, Nature)
  • "Adeno-Associated Virus-Induced Dorsal Root Ganglion Pathology" (2020, Human Gene Therapy)
  • "Helper lipid structure influences protein adsorption and delivery of lipid nanoparticles to spleen and liver" (2020, Biomaterials Science)
  • "Moving Forward After Two Deaths in a Gene Therapy Trial of Myotubular Myopathy" (2020, Human Gene Therapy)

Best Publications

  • Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy

    Yiping Yang;Frederick A. Nunes;Klara Berencsi;Emma E. Furth

  • Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

    Guang-Ping Gao;Mauricio R. Alvira;Lili Wang;Roberto Calcedo

  • Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

    Steven E Raper;Narendra Chirmule;Frank S Lee;Nelson A Wivel

  • Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses.

    Yiping Yang;Qin Li;H. C. J. Ertl;J. M. Wilson

  • Human β-Defensin-1 Is a Salt-Sensitive Antibiotic in Lung That Is Inactivated in Cystic Fibrosis

    Mitchell J Goldman;G.Mark Anderson;Ethan D Stolzenberg;U.Prasad Kari

  • Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues

    Guangping Gao;Luk H. Vandenberghe;Mauricio R. Alvira;You Lu

  • A model system for in vivo gene transfer into the central nervous system using an adenoviral vector.

    Beverly L. Davidson;Edward D. Allen;Karen F. Kozarsky;James M. Wilson

  • Recombinant adeno-associated virus for muscle directed gene therapy

    Krishna J. Fisher;Karin Jooss;James Alston;Yiping Yang

  • The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface

    Robert Bals;Xiaorong Wang;Michael Zasloff;James M. Wilson

  • Noninvasive determination of left ventricular end-systolic stress: validation of the method and initial application.

    N Reichek;J Wilson;M St John Sutton;T A Plappert

  • MHC class I-cestricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses

    Yiping Yang;Yiping Yang;Hildegund C.J. Ertl;James M. Wilson

  • Worldwide Epidemiology of Neutralizing Antibodies to Adeno-Associated Viruses

    Roberto Calcedo;Luk H. Vandenberghe;Guangping Gao;Jianping Lin

  • Immune responses to adenovirus and adeno-associated virus in humans.

    N Chirmule;K J Propert;S A Magosin;Y Qian

  • Postoperative atrial fibrillation and mortality after coronary artery bypass surgery.

    Rollo P. Villareal;Ramesh Hariharan;Brant C. Liu;Biswajit Kar

  • Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer.

    Mitchell L. Drumm;Heidi A. Pope;William H. Cliff;Johanna M. Rommens

  • Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver

    John F. Engelhardt;Xuehai Ye;Benjamin Doranz;James M. Wilson

  • Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics

    Artur V. Cideciyan;Tomas S. Aleman;Sanford L. Boye;Sharon B. Schwartz

  • Submucosal glands are the predominant site of CFTR expression in the human bronchus.

    John F. Engelhardt;James R. Yankaskas;Stephen A. Ernst;Yiping Yang

  • Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis.

    K. J. Fisher;Guang-Ping Gao;M. D. Weitzman;R. Dematteo

  • Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung

    R. Bals;Xiaorong Wang;Zhongren Wu;T. Freeman

Frequent Co-Authors

Guangping Gao
Guangping Gao University of Massachusetts Chan Medical School
Peter Bell
Peter Bell University of Pennsylvania
Roberto Calcedo
Roberto Calcedo Affinia Therapeutics
Luk H. Vandenberghe
Luk H. Vandenberghe Massachusetts Eye and Ear Infirmary
Yiping Yang
Yiping Yang The Ohio State University
John F. Engelhardt
John F. Engelhardt University of Iowa
Alberto Auricchio
Alberto Auricchio Telethon Institute Of Genetics And Medicine
Jean Bennett
Jean Bennett University of Pennsylvania
Daniel J. Rader
Daniel J. Rader University of Pennsylvania
William N. Kelley
William N. Kelley University of Pennsylvania

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