World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
86
Citations
31548
World Ranking
2929
National Ranking
1500

Medicine

D-Index
86
Citations
31460
World Ranking
13992
National Ranking
7101

Research.com Recognitions

  • 2015 - Fellow of the American Academy of Arts and Sciences
  • 1988 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Jean Bennett is affiliated with the University of Pennsylvania in the United States. Their primary research focus spans multiple fields within medicine and biochemistry, genetics, and molecular biology.

The main fields of study for Bennett include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Their research further delves into subfields such as:

  • Molecular Biology
  • Ophthalmology
  • Radiology, Nuclear Medicine and Imaging
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience

The scientific topics predominantly investigated by Bennett cover:

  • Retinal Development and Disorders
  • Retinal Diseases and Treatments
  • CRISPR and Genetic Engineering
  • Virus-based gene therapy research
  • Retinopathy of Prematurity Studies
  • Retinal and Optic Conditions
  • Ophthalmology and Visual Impairment Studies

Among recent published papers are:

  • "Durability of Voretigene Neparvovec for Biallelic RPE65-Mediated Inherited Retinal Disease," 2021, Ophthalmology
  • "Clinical Perspective: Treating RPE65-Associated Retinal Dystrophy," 2020, Molecular Therapy
  • "Broader Implications of Progressive Liver Dysfunction and Lethal Sepsis in Two Boys following Systemic High-Dose AAV," 2020, Molecular Therapy
  • "Rescue of retinal ganglion cells in optic nerve injury using cell-selective AAV mediated delivery of SIRT1," 2021, Gene Therapy
  • "Adeno-Associated Virus Serotype 2-hCHM Subretinal Delivery to the Macula in Choroideremia," 2022, Ophthalmology

Bennett has frequently collaborated with several co-authors, including:

  • Albert M. Maguire
  • Tomás S. Alemán
  • Manzar Ashtari
  • Bart P. Leroy
  • Leona Serrano

Their work is commonly published in journals such as:

  • Molecular Therapy
  • Molecular Therapy - Methods & Clinical Development
  • Translational Vision Science & Technology
  • Ophthalmology
  • Gene Therapy

Jean Bennett's career includes recognition as a Fellow of the American Academy of Arts and Sciences in 2015 and as a Fellow of the American Association for the Advancement of Science (AAAS) in 1988.

Best Publications

  • Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

    Albert M. Maguire;Francesca Simonelli;Eric A. Pierce;Edward N. Pugh

  • Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial

    Stephen Russell;Jean Bennett;Jennifer A. Wellman;Daniel C. Chung

  • Gene therapy restores vision in a canine model of childhood blindness.

    Gregory M. Acland;Gustavo D. Aguirre;Jharna Ray;Qi Zhang

  • Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial

    Albert M. Maguire;Albert M. Maguire;Katherine A. High;Katherine A. High;Alberto Auricchio;J. Fraser Wright;J. Fraser Wright

  • Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model.

    Samuel J Reich;Joshua Fosnot;Akiko Kuroki;Waixing Tang

  • Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration.

    Francesca Simonelli;Albert M Maguire;Albert M Maguire;Francesco Testa;Eric A Pierce

  • Lateral connectivity and contextual interactions in macaque primary visual cortex.

    Dan D Stettler;Aniruddha Das;Jean Bennett;Charles D Gilbert

  • Long-Term Restoration of Rod and Cone Vision by Single Dose rAAV-Mediated Gene Transfer to the Retina in a Canine Model of Childhood Blindness

    Gregory M. Acland;Gustavo D. Aguirre;Jean Bennett;Tomas S. Aleman

  • Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate

    Neena B. Haider;Samuel G. Jacobson;Artur V. Cideciyan;Ruth Swiderski

  • Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial

    Jean Bennett;Jean Bennett;Jennifer Wellman;Kathleen A Marshall;Sarah McCague

  • A locus control region adjacent to the human red and green visual pigment genes

    Yanshu Wang;Jennifer P. Macke;Shannath L. Merbs;Donald J. Zack

  • AAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness

    Jean Bennett;Jean Bennett;Manzar Ashtari;Jennifer Wellman;Kathleen A. Marshall

  • The molecular basis of antibody formation: a paradox

    W J Dreyer;J C Bennett

  • Exchange of surface proteins impacts on viral vector cellular specificity and transduction characteristics: the retina as a model

    Alberto Auricchio;Gary Kobinger;Vibha Anand;Markus Hildinger

  • Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy

    Jean Bennett;Teruyo Tanabe;Dexue Sun;Dexue Sun;Dexue Sun;Yong Zeng

  • Three-Year Follow-up after Unilateral Subretinal Delivery of Adeno-Associated Virus in Patients with Leber Congenital Amaurosis Type 2

    Francesco Testa;Albert M. Maguire;Albert M. Maguire;Settimio Rossi;Eric A. Pierce

  • Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice

    Mariacarmela Allocca;Monica Doria;Marco Petrillo;Pasqualina Colella

  • Efficacy, Safety, and Durability of Voretigene Neparvovec-rzyl in RPE65 Mutation-Associated Inherited Retinal Dystrophy: Results of Phase 1 and 3 Trials.

    Albert M. Maguire;Albert M. Maguire;Stephen Russell;Jennifer A. Wellman;Daniel C. Chung

  • Reversal of Blindness in Animal Models of Leber Congenital Amaurosis Using Optimized AAV2-mediated Gene Transfer

    Jeannette Bennicelli;John Fraser Wright;John Fraser Wright;Andras Komaromy;Jonathan B Jacobs

  • Adenovirus vector-mediated in vivo gene transfer into adult murine retina.

    J Bennett;J Wilson;D Sun;B Forbes

Frequent Co-Authors

Albert M. Maguire
Albert M. Maguire University of Pennsylvania
Tomas S. Aleman
Tomas S. Aleman University of Pennsylvania
Daniel C. Chung
Daniel C. Chung Harvard University
Katherine A. High
Katherine A. High Children's Hospital of Philadelphia
Samuel G. Jacobson
Samuel G. Jacobson University of Pennsylvania
James M. Wilson
James M. Wilson University of Pennsylvania
Alberto Auricchio
Alberto Auricchio Telethon Institute Of Genetics And Medicine
Artur V. Cideciyan
Artur V. Cideciyan University of Pennsylvania
Edwin M. Stone
Edwin M. Stone University of Iowa
Luk H. Vandenberghe
Luk H. Vandenberghe Massachusetts Eye and Ear Infirmary

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