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Medicine

D-Index
71
Citations
16931
World Ranking
20007
National Ranking
9966

Overview

Tomas S. Aleman is affiliated with the University of Pennsylvania in the United States. Their research primarily focuses on ophthalmology and related molecular biology fields, contributing extensively to the understanding of retinal development, retinal diseases, and treatments.

Their published work has been featured in several notable scientific venues, with frequent publications in:

  • Investigative Ophthalmology & Visual Science
  • Retinal Cases & Brief Reports
  • Ophthalmic Genetics
  • Translational Vision Science & Technology
  • Molecular Therapy

Major academic fields associated with Tomas S. Aleman include Medicine and Biochemistry, Genetics and Molecular Biology. Within these fields, the subfields they contribute to are:

  • Ophthalmology
  • Molecular Biology
  • Radiology, Nuclear Medicine and Imaging
  • Cellular and Molecular Neuroscience
  • Genetics

Their research spans several key topics involving the retina and vision science, including:

  • Retinal Development and Disorders
  • Retinal Diseases and Treatments
  • Glaucoma and retinal disorders
  • Photoreceptor and optogenetics research
  • Retinopathy of Prematurity Studies
  • Retinal and Macular Surgery
  • Cellular transport and secretion

Tomas S. Aleman has collaborated frequently with other researchers, including Erin O'Neil, Albert M. Maguire, Artur V. Cideciyan, Jean Bennett, and Emma Bedoukian.

Select recent publications include:

  • "Clinical Perspective: Treating RPE65-Associated Retinal Dystrophy", 2020, Molecular Therapy
  • "Gene Editing for CEP290-Associated Retinal Degeneration", 2024, New England Journal of Medicine
  • "Adeno-Associated Virus Serotype 2-hCHM Subretinal Delivery to the Macula in Choroideremia", 2022, Ophthalmology
  • "Assessment of Visual Function with Cotoretigene Toliparvovec in X-Linked Retinitis Pigmentosa in the Randomized XIRIUS Phase 2/3 Study", 2024, Ophthalmology
  • "A Virtual Reality Orientation and Mobility Test for Inherited Retinal Degenerations: Testing a Proof-of-Concept After Gene Therapy", 2021, Clinical ophthalmology

Best Publications

  • Gene therapy restores vision in a canine model of childhood blindness.

    Gregory M. Acland;Gustavo D. Aguirre;Jharna Ray;Qi Zhang

  • Treatment of Leber Congenital Amaurosis Due to RPE65 Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial

    William W. Hauswirth;Tomas S. Aleman;Shalesh Kaushal;Artur V. Cideciyan

  • Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics

    Artur V. Cideciyan;Tomas S. Aleman;Sanford L. Boye;Sharon B. Schwartz

  • Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years

    Samuel G. Jacobson;Artur V. Cideciyan;Ramakrishna Ratnakaram;Elise Heon

  • Long-Term Restoration of Rod and Cone Vision by Single Dose rAAV-Mediated Gene Transfer to the Retina in a Canine Model of Childhood Blindness

    Gregory M. Acland;Gustavo D. Aguirre;Jean Bennett;Tomas S. Aleman

  • Human RPE65 Gene Therapy for Leber Congenital Amaurosis: Persistence of Early Visual Improvements and Safety at 1 Year

    Artur V. Cideciyan;William W. Hauswirth;Tomas S. Aleman;Shalesh Kaushal

  • Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa.

    Fong-Qi Liang;Tomas S. Aleman;Nadine S. Dejneka;Lorita Dudus

  • Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa

    William A. Beltran;Artur V. Cideciyan;Alfred S. Lewin;Simone Iwabe

  • Stable transgene expression in rod photoreceptors after recombinant adeno-associated virus-mediated gene transfer to monkey retina

    Jean Bennett;Albert M. Maguire;Artur V. Cideciyan;Michael Schnell

  • Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness.

    J. Preston Van Hooser;Tomas S. Aleman;Yu Guang He;Artur V. Cideciyan

  • Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success

    Samuel G. Jacobson;Tomas S. Aleman;Artur V. Cideciyan;Alexander Sumaroka

  • Mutations in ABCA4 result in accumulation of lipofuscin before slowing of the retinoid cycle: a reappraisal of the human disease sequence

    Artur V. Cideciyan;Tomas S. Aleman;Malgorzata Swider;Sharon B. Schwartz

  • Vision 1 year after gene therapy for Leber's congenital amaurosis.

    Artur V. Cideciyan;William W. Hauswirth;Tomas S. Aleman;Shalesh Kaushal

  • Safety of Recombinant Adeno-Associated Virus Type 2–RPE65 Vector Delivered by Ocular Subretinal Injection

    Samuel G. Jacobson;Gregory M. Acland;Gustavo D. Aguirre;Tomas S. Aleman

  • The nuclear receptor NR2E3 plays a role in human retinal photoreceptor differentiation and degeneration.

    Ann H. Milam;Linda Rose;Artur V. Cideciyan;Mark R. Barakat

  • Crumbs homolog 1 (CRB1) mutations result in a thick human retina with abnormal lamination

    Samuel G. Jacobson;Artur V. Cideciyan;Tomas S. Aleman;Michael J. Pianta

  • In vivo dynamics of retinal injury and repair in the rhodopsin mutant dog model of human retinitis pigmentosa

    Artur V. Cideciyan;Samuel G. Jacobson;Tomas S. Aleman;Danian Gu

  • In Utero Gene Therapy Rescues Vision in a Murine Model of Congenital Blindness

    Nadine S Dejneka;Enrico M Surace;Tomas S Aleman;Artur V Cideciyan

  • ABCA4 disease progression and a proposed strategy for gene therapy

    Artur V. Cideciyan;Malgorzata Swider;Tomas S. Aleman;Yaroslav Tsybovsky

  • Remodeling of the human retina in choroideremia: rab escort protein 1 (REP-1) mutations.

    Samuel G. Jacobson;Artur V. Cideciyan;Alexander Sumaroka;Tomas S. Aleman

Frequent Co-Authors

Samuel G. Jacobson
Samuel G. Jacobson University of Pennsylvania
Artur V. Cideciyan
Artur V. Cideciyan University of Pennsylvania
Jean Bennett
Jean Bennett University of Pennsylvania
Edwin M. Stone
Edwin M. Stone University of Iowa
Albert M. Maguire
Albert M. Maguire University of Pennsylvania
William W. Hauswirth
William W. Hauswirth University of Florida
Gustavo D. Aguirre
Gustavo D. Aguirre University of Pennsylvania
Sanford L. Boye
Sanford L. Boye University of Florida
Gregory M. Acland
Gregory M. Acland Cornell University
Krzysztof Palczewski
Krzysztof Palczewski University of California, Irvine

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