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Genetics

D-Index
73
Citations
17328
World Ranking
2060
National Ranking
939

Research.com Recognitions

  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Gustavo D. Aguirre is affiliated with the University of Pennsylvania in the United States. Their research spans multiple interconnected fields, primarily in neuroscience, medicine, and biochemistry, genetics, and molecular biology. Within these broad areas, they have contributed extensively to several subfields, including cognitive neuroscience, molecular biology, ophthalmology, radiology, nuclear medicine and imaging, and cellular and molecular neuroscience.

The scientist's work focuses on a range of topics related to visual and sensory functions. Key research themes include retinal development and disorders, visual perception and processing mechanisms, migraine and headache studies, olfactory and sensory function studies, glaucoma and retinal disorders, retinal diseases and treatments, and circadian rhythm and melatonin.

Aguirre has authored papers published in several scientific venues. The most frequent publication outlets include bioRxiv (Cold Spring Harbor Laboratory) with 28 publications, the Journal of Vision with 12, Investigative Ophthalmology & Visual Science with 7, Scientific Reports with 6, and Neurology with 5 publications.

Among the recent papers authored or coauthored by Aguirre are:

  • QSIPrep: an integrative platform for preprocessing and reconstructing diffusion MRI data (2021, Nature Methods)
  • Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau (2020, Science)
  • scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution (2021, eLife)
  • Systemic immunosuppression promotes survival and integration of subretinally implanted human ESC-derived photoreceptor precursors in dogs (2022, Stem Cell Reports)
  • Morality is in the eye of the beholder: the neurocognitive basis of the "anomalous-is-bad" stereotype (2021, Annals of the New York Academy of Sciences)

Frequent collaborators in their research include William A. Beltran (23 coauthored works), Carlyn Patterson Gentile (16), Edda B. Haggerty (13), David H. Brainard (13), and Valérie Dufour (11).

Gustavo D. Aguirre was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2017, an award that marks contributions in scientific research and scholarship.

Best Publications

  • Gene therapy restores vision in a canine model of childhood blindness.

    Gregory M. Acland;Gustavo D. Aguirre;Jharna Ray;Qi Zhang

  • Long-Term Restoration of Rod and Cone Vision by Single Dose rAAV-Mediated Gene Transfer to the Retina in a Canine Model of Childhood Blindness

    Gregory M. Acland;Gustavo D. Aguirre;Jean Bennett;Tomas S. Aleman

  • Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement

    Artur V. Cideciyan;Samuel G. Jacobson;William A. Beltran;Alexander Sumaroka

  • Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa.

    Weng Tao;Rong Wen;Moses B Goddard;Sandy D Sherman

  • Unique topographic separation of two spectral classes of cones in the mouse retina

    A Szél;P Röhlich;A R Caffé;B Juliusson

  • Gene therapy rescues cone function in congenital achromatopsia

    András M. Komáromy;John J. Alexander;John J. Alexander;Jessica S. Rowlan;Monique M. Garcia;Monique M. Garcia

  • Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa

    William A. Beltran;Artur V. Cideciyan;Alfred S. Lewin;Simone Iwabe

  • A Linkage Map of the Canine Genome

    Cathryn S. Mellersh;Amelia A. Langston;Gregory M. Acland;Melissa A. Fleming

  • Congenital stationary night blindness in the dog: common mutation in the RPE65 gene indicates founder effect

    Gustavo D Aguirre;Victoria Baldwin;Sue Pearce-Kelling;Kristina Narfström

  • A second-generation genetic linkage map of the domestic dog, Canis familiaris.

    Mark W. Neff;Karl W. Broman;Cathryn S. Mellersh;Kunal Ray

  • Safety of Recombinant Adeno-Associated Virus Type 2–RPE65 Vector Delivered by Ocular Subretinal Injection

    Samuel G. Jacobson;Gregory M. Acland;Gustavo D. Aguirre;Tomas S. Aleman

  • In vivo dynamics of retinal injury and repair in the rhodopsin mutant dog model of human retinitis pigmentosa

    Artur V. Cideciyan;Samuel G. Jacobson;Tomas S. Aleman;Danian Gu

  • Different RPGR exon ORF15 mutations in Canids provide insights into photoreceptor cell degeneration

    Qi Zhang;Gregory M. Acland;Wen X. Wu;Jennifer L. Johnson

  • Identical mutation in a novel retinal gene causes progressive rod-cone degeneration in dogs and retinitis pigmentosa in humans.

    Barbara Zangerl;Orly Goldstein;Alisdair R. Philp;Sarah J.P. Lindauer

  • Canine CNGB3 mutations establish cone degeneration as orthologous to the human achromatopsia locus ACHM3

    Duska J. Sidjanin;Jennifer K. Lowe;John L. McElwee;Bruce S. Milne

  • Naturally occurring rhodopsin mutation in the dog causes retinal dysfunction and degeneration mimicking human dominant retinitis pigmentosa.

    James W. Kijas;Artur V. Cideciyan;Tomas S. Aleman;Michael J. Pianta

  • Therapeutic neonatal hepatic gene therapy in mucopolysaccharidosis VII dogs

    Katherine Parker Ponder;John R Melniczek;Lingfei Xu;Margaret A Weil

  • Breed relationships facilitate fine-mapping studies: A 7.8-kb deletion cosegregates with Collie eye anomaly across multiple dog breeds

    Heidi G. Parker;Anna V. Kukekova;Dayna T. Akey;Orly Goldstein

  • The Pathology of the Feline Model of Mucopolysaccharidosis VI

    Mark E Haskins;Gustavo D Aguirre;Peter F Jezyk;Donald F Patterson

  • The β subunit of cyclic GMP phosphodiesterase mRNA is deficient in canine rod-cone dysplasia 1

    Debora B. Farber;Janet Seager Danciger;Gustavo Aguirre

Frequent Co-Authors

Gregory M. Acland
Gregory M. Acland Cornell University
Samuel G. Jacobson
Samuel G. Jacobson University of Pennsylvania
William W. Hauswirth
William W. Hauswirth University of Florida
Artur V. Cideciyan
Artur V. Cideciyan University of Pennsylvania
Kunal Ray
Kunal Ray Academy of Scientific and Innovative Research
Sanford L. Boye
Sanford L. Boye University of Florida
Alfred S. Lewin
Alfred S. Lewin University of Florida
Elaine A. Ostrander
Elaine A. Ostrander National Institutes of Health
Tomas S. Aleman
Tomas S. Aleman University of Pennsylvania
Edwin M. Stone
Edwin M. Stone University of Iowa

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