Samuel G. Jacobson mostly deals with Genetics, Retinal, Retina, Retinal degeneration and Retinitis pigmentosa. The Genetics study combines topics in areas such as Rhodopsin, Visual phototransduction and Cell biology. His Retinal study improves the overall literature in Ophthalmology.
In his work, Morphogenesis is strongly intertwined with Optic nerve, which is a subfield of Retina. His Retinal degeneration research is multidisciplinary, relying on both Endocrinology, Outer nuclear layer, Neurodegeneration, Retinal Rod Photoreceptor Cells and Internal medicine. He interconnects Phenotype, Anatomy, Point mutation, Molecular biology and Visual field in the investigation of issues within Retinitis pigmentosa.
Samuel G. Jacobson mainly focuses on Retinal, Genetics, Retina, Ophthalmology and Retinitis pigmentosa. His Retinal research incorporates themes from Genetic enhancement and Cell biology. His research on Genetics frequently links to adjacent areas such as Molecular biology.
His Retina study combines topics in areas such as Rhodopsin, Anatomy and Pathology. His biological study spans a wide range of topics, including Peripherin, Gene mutation and Exon. Samuel G. Jacobson has included themes like Endocrinology, Degeneration, Phenotype, Internal medicine and Visual phototransduction in his Retinal degeneration study.
His scientific interests lie mostly in Ophthalmology, Retinal, Retina, Retinal degeneration and Retinitis pigmentosa. His study in Ophthalmology is interdisciplinary in nature, drawing from both Clinical trial and Cohort. His Retinal research is multidisciplinary, incorporating elements of Optical coherence tomography and Genetic enhancement.
His work deals with themes such as Fovea centralis, Pathophysiology and Anatomy, which intersect with Retina. His research in Retinal degeneration intersects with topics in Mutation, Retinal pigment epithelium, Phenotype, Pathology and Retinal regeneration. His Retinitis pigmentosa research includes elements of Maculopathy, Allele and Transgene.
Samuel G. Jacobson mainly investigates Retina, Ophthalmology, Retinal, Retinal degeneration and Retinitis pigmentosa. His studies in Retina integrate themes in fields like Anatomy, Foveal and Pathology. His study in the field of Visual acuity, Electroretinography and Leber congenital amaurosis is also linked to topics like Childhood blindness.
His research brings together the fields of Genetic enhancement and Retinal. His work carried out in the field of Retinal degeneration brings together such families of science as Retinal regeneration, Disease, Mutant and ABCA4. His Retinitis pigmentosa study combines topics from a wide range of disciplines, such as Phenotype, Loss function and Rhodopsin, Retinal Rod Photoreceptor Cells.
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Gene therapy restores vision in a canine model of childhood blindness.
Gregory M. Acland;Gustavo D. Aguirre;Jharna Ray;Qi Zhang.
Nature Genetics (2001)
Treatment of Leber Congenital Amaurosis Due to RPE65 Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial
William W. Hauswirth;Tomas S. Aleman;Shalesh Kaushal;Artur V. Cideciyan.
Human Gene Therapy (2008)
Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics
Artur V. Cideciyan;Tomas S. Aleman;Sanford L. Boye;Sharon B. Schwartz.
Proceedings of the National Academy of Sciences of the United States of America (2008)
Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa.
Andreas Gal;Yun Li;Debra A. Thompson;Jessica Weir.
Nature Genetics (2000)
Gene Therapy for Leber Congenital Amaurosis Caused by RPE65 Mutations: Safety and Efficacy in 15 Children and Adults Followed Up to 3 Years
Samuel G. Jacobson;Artur V. Cideciyan;Ramakrishna Ratnakaram;Elise Heon.
Archives of Ophthalmology (2012)
Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor
Carol L. Freund;Cheryl Y. Gregory-Evans;Takahisa Furukawa;Myrto Papaioannou.
Long-Term Restoration of Rod and Cone Vision by Single Dose rAAV-Mediated Gene Transfer to the Retina in a Canine Model of Childhood Blindness
Gregory M. Acland;Gustavo D. Aguirre;Jean Bennett;Tomas S. Aleman.
Molecular Therapy (2005)
Rhodopsin mutations in autosomal dominant retinitis pigmentosa.
Ching Hwa Sung;Carol M. Davenport;Jill C. Hennessey;Irene H. Maumenee.
Proceedings of the National Academy of Sciences of the United States of America (1991)
Mutation of a nuclear receptor gene, NR2E3 , causes enhanced S cone syndrome, a disorder of retinal cell fate
Neena B. Haider;Samuel G. Jacobson;Artur V. Cideciyan;Ruth Swiderski.
Nature Genetics (2000)
Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement
Artur V. Cideciyan;Samuel G. Jacobson;William A. Beltran;Alexander Sumaroka.
Proceedings of the National Academy of Sciences of the United States of America (2013)
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