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William W. Hauswirth

William W. Hauswirth

D-Index & Metrics

Molecular Biology

D-Index
110
Citations
42214
World Ranking
373
National Ranking
215

Medicine

D-Index
112
Citations
43496
World Ranking
5163
National Ranking
2793

Research.com Recognitions

  • 2013 - The Llura Liggett Gund Award, Foundation Fighting Blindness for using non-harmful adeno-associated viruses (AAVs) to transport healthy DNA into retinal cells at the back of the eye, showing that gene therapy could restore vision in animal models, including Briard dogs. His team’s approach was then used in human clinical trials where children and young adults virtually blind from Leber congenital amaurosis (LCA) have had significant vision restored.

Overview

William W. Hauswirth is affiliated with the University of Florida in the United States, contributing extensively to the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their research primarily spans Molecular Biology, Ophthalmology, Cellular and Molecular Neuroscience, Genetics, and Radiology, Nuclear Medicine and Imaging.

The scientist's work encompasses key topics such as:

  • Retinal Development and Disorders
  • Photoreceptor and Optogenetics Research
  • Retinal Diseases and Treatments
  • Glaucoma and Retinal Disorders
  • Mitochondrial Function and Pathology
  • Virus-based Gene Therapy Research
  • ATP Synthase and ATPases Research

William W. Hauswirth has published papers in several significant scientific venues including Molecular Therapy, UNC Libraries, Gene Therapy, Investigative Ophthalmology & Visual Science, and Translational Vision Science & Technology.

Examples of recent papers authored or co-authored by Hauswirth include:

  • Interplay between cell-adhesion molecules governs synaptic wiring of cone photoreceptors (2020) - Proceedings of the National Academy of Sciences
  • Gene therapy reforms photoreceptor structure and restores vision in NPHP5-associated Leber congenital amaurosis (2021) - Molecular Therapy
  • Interocular Symmetry of Foveal Cone Topography in Congenital Achromatopsia (2020) - Current Eye Research
  • XIAP gene therapy effects on retinal ganglion cell structure and function in a mouse model of glaucoma (2021) - Gene Therapy
  • Prdm1 overexpression causes a photoreceptor fate-shift in nascent, but not mature, bipolar cells (2020) - Developmental Biology

Frequent collaborators in their research include John Guy, Michel Michaelides, Artur V. Cideciyan, Valérie Dufour, and Ana Ripolles-García.

Among awards, Hauswirth received The Llura Liggett Gund Award from the Foundation Fighting Blindness in 2013. This recognition was for work using non-harmful adeno-associated viruses (AAVs) to transport healthy DNA into retinal cells at the back of the eye, demonstrating the potential of gene therapy to restore vision in animal models. This approach has subsequently informed human clinical trials for conditions such as Leber congenital amaurosis.

Best Publications

  • Gene therapy restores vision in a canine model of childhood blindness.

    Gregory M. Acland;Gustavo D. Aguirre;Jharna Ray;Qi Zhang

  • Treatment of Leber Congenital Amaurosis Due to RPE65 Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial

    William W. Hauswirth;Tomas S. Aleman;Shalesh Kaushal;Artur V. Cideciyan

  • A "humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cells.

    Sergei Zolotukhin;Mark Potter;William W. Hauswirth;John Guy

  • A muscleblind knockout model for myotonic dystrophy.

    Rahul N. Kanadia;Karen A. Johnstone;Ami Mankodi;Codrin Lungu

  • Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics

    Artur V. Cideciyan;Tomas S. Aleman;Sanford L. Boye;Sharon B. Schwartz

  • Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years

    Samuel G. Jacobson;Artur V. Cideciyan;Ramakrishna Ratnakaram;Elise Heon

  • DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

    Hiroki Kaneko;Sami Dridi;Valeria Tarallo;Bradley D. Gelfand

  • Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors.

    Sergei Zolotukhin;Mark Potter;Irene Zolotukhin;Yoshihisa Sakai

  • DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88

    Valeria Tarallo;Yoshio Hirano;Bradley D. Gelfand;Sami Dridi

  • Long-Term Restoration of Rod and Cone Vision by Single Dose rAAV-Mediated Gene Transfer to the Retina in a Canine Model of Childhood Blindness

    Gregory M. Acland;Gustavo D. Aguirre;Jean Bennett;Tomas S. Aleman

  • Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa.

    Alfred S. Lewin;Kimberly A. Drenser;William W. Hauswirth;Shimpei Nishikawa

  • Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus

    J G Flannery;S Zolotukhin;M I Vaquero;M M LaVail

  • Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement

    Artur V. Cideciyan;Samuel G. Jacobson;William A. Beltran;Alexander Sumaroka

  • Mitochondrial DNA polymorphism in a maternal lineage of Holstein cows

    William W. Hauswirth;Philip J. Laipis

  • High-efficiency Transduction of the Mouse Retina by Tyrosine-mutant AAV Serotype Vectors

    Hilda Petrs-Silva;Astra Dinculescu;Qiuhong Li;Seok-Hong Min

  • Gene therapy with brain-derived neurotrophic factor as a protection: Retinal ganglion cells in a rat glaucoma model

    Keith R. G. Martin;Harry A. Quigley;Donald J. Zack;Hana Levkovitch-Verbin

  • Integration of the adeno-associated virus genome into cellular DNA in latently infected human Detroit 6 cells.

    A K Cheung;M D Hoggan;W W Hauswirth;K I Berns

  • Human RPE65 Gene Therapy for Leber Congenital Amaurosis: Persistence of Early Visual Improvements and Safety at 1 Year

    Artur V. Cideciyan;William W. Hauswirth;Tomas S. Aleman;Shalesh Kaushal

  • Improvement and decline in vision with gene therapy in childhood blindness.

    Samuel G. Jacobson;Artur V. Cideciyan;Alejandro J. Roman;Alexander Sumaroka

  • Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus (gene therapyyretinayretinitis pigmentosa)

    John G. Flannery;Sergei Zolotukhin;M. Lavail;Nicholas Muzyczka

Frequent Co-Authors

Sanford L. Boye
Sanford L. Boye University of Florida
Alfred S. Lewin
Alfred S. Lewin University of Florida
Vince A. Chiodo
Vince A. Chiodo University of Florida
Gustavo D. Aguirre
Gustavo D. Aguirre University of Pennsylvania
Samuel G. Jacobson
Samuel G. Jacobson University of Pennsylvania
Artur V. Cideciyan
Artur V. Cideciyan University of Pennsylvania
Bo Chang
Bo Chang University of California, Los Angeles
Nicholas Muzyczka
Nicholas Muzyczka University of Florida
John G. Flannery
John G. Flannery University of California, Berkeley
Kenneth I. Berns
Kenneth I. Berns University of Florida

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