Bo Chang spends much of his time researching Genetics, Retinal, Retinal degeneration, Retina and Electroretinography. His work carried out in the field of Genetics brings together such families of science as Achromatopsia, Intraocular pressure, Glaucoma and Retinal Cone Photoreceptor Cells. Genetic enhancement, Genetic model, Ophthalmoscopy and Choroidal neovascularization is closely connected to Anatomy in his research, which is encompassed under the umbrella topic of Retinal.
His Retinal degeneration research incorporates themes from Molecular biology, Retinitis pigmentosa and Frameshift mutation. The Retinitis pigmentosa study combines topics in areas such as Transport protein and Cell biology. In his study, which falls under the umbrella issue of Retina, Color Vision Defects is strongly linked to Pathology.
Bo Chang mainly focuses on Genetics, Retinal degeneration, Retinal, Molecular biology and Retina. Bo Chang has researched Retinal degeneration in several fields, including Retinitis pigmentosa and Pathology. In Retinal, he works on issues like Cell biology, which are connected to Photoreceptor cell.
His study focuses on the intersection of Molecular biology and fields such as Mutant with connections in the field of Exon. His Retina research is multidisciplinary, incorporating perspectives in Genetic enhancement and Anatomy. His work focuses on many connections between Electroretinography and other disciplines, such as Retinal Cone Photoreceptor Cells, that overlap with his field of interest in Achromatopsia.
Bo Chang mostly deals with Molecular biology, Retinal pigment epithelium, Retinal, Retina and Cell biology. His Molecular biology research includes elements of Electroretinography, Characterization, Mutant, Mutation and Exudative retinal detachment. His study in Electroretinography is interdisciplinary in nature, drawing from both Erg, Retinal Cone Photoreceptor Cells and Frameshift mutation.
His Retina research focuses on Retinal degeneration in particular. His studies deal with areas such as Allele and Degenerative disease as well as Retinal degeneration. Bo Chang has included themes like Photoreceptor cell, Genetics and LINC complex in his Cell biology study.
Bo Chang mostly deals with Retinal, Retinal pigment epithelium, Retinal degeneration, Anatomy and Retina. The concepts of his Retinal study are interwoven with issues in Cancer research, Angiogenesis, Neovascularization and Cell biology. In his research, Molecular biology and Electroretinography is intimately related to Regulation of gene expression, which falls under the overarching field of Cell biology.
His Retinal degeneration study combines topics from a wide range of disciplines, such as Erg, Genetic enhancement, Neurodegeneration and Outer nuclear layer. His Anatomy research incorporates themes from Gene therapy of the human retina, Retinal Cone Photoreceptor Cells, Edema and Degenerative disease. Retina is a subfield of Neuroscience that Bo Chang tackles.
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Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice.
Simon W M John;Richard S. Smith;Olga V. Savinova;Norman L. Hawes.
Investigative Ophthalmology & Visual Science (1998)
Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice.
Michael G Anderson;Richard S Smith;Norman L Hawes;Adriana Zabaleta.
Nature Genetics (2002)
In-frame deletion in a novel centrosomal/ciliary protein CEP290/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the rd16 mouse
Bo Chang;Hemant Khanna;Norman Hawes;David Jimeno.
Human Molecular Genetics (2006)
CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina
Adrienne K. Mehalow;Shuhei Kameya;Richard S. Smith;Norman L. Hawes.
Human Molecular Genetics (2003)
Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice.
Bo Chang;Richard S Smith;Norman L Hawes;Michael G Anderson.
Nature Genetics (1999)
A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse
Novrouz B. Akhmedov;Natik I. Piriev;Bo Chang;Ana Lia Rapoport.
Proceedings of the National Academy of Sciences of the United States of America (2000)
Retinal degeneration 12 (rd12): a new, spontaneously arising mouse model for human Leber congenital amaurosis (LCA)
Ji Jing Pang;Bo Chang;Norman L. Hawes;Ronald E. Hurd.
Molecular Vision (2005)
Restoration of cone vision in a mouse model of achromatopsia
John J Alexander;Yumiko Umino;Drew Everhart;Bo Chang.
Nature Medicine (2007)
Biology and therapy of inherited retinal degenerative disease: insights from mouse models.
Shobi Veleri;Csilla H. Lazar;Bo Chang;Paul A. Sieving.
Disease Models & Mechanisms (2015)
Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis.
Ji-jing Pang;Bo Chang;Ashok Kumar;Steven Nusinowitz.
Molecular Therapy (2006)
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