World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
76
Citations
23000
World Ranking
5006
National Ranking
2403

Medicine

D-Index
76
Citations
22972
World Ranking
18732
National Ranking
9333

Overview

Simon W. M. John is affiliated with Columbia University in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a total of 64 publications in Medicine and 30 in Biochemistry, Genetics and Molecular Biology. Within these fields, their work is heavily focused on subfields such as Ophthalmology, Molecular Biology, Neurology, Pathology and Forensic Medicine, and Radiology, Nuclear Medicine and Imaging.

The main topics of Simon W. M. John's research involve glaucoma and retinal disorders, retinal development and disorders, retinal diseases and treatments, corneal surgery and disorders, metabolomics and mass spectrometry studies, neuroinflammation and neurodegeneration mechanisms, and neurological disorders and treatments.

They have contributed extensively to scientific literature with notable recent papers including:

  • Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma (2021), published in JAMA Ophthalmology
  • Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin (2020), published in Proceedings of the National Academy of Sciences
  • Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2J mice (2020), published in Molecular Brain
  • Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms (2022), published in Investigative Ophthalmology & Visual Science
  • Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice (2020), published in Journal of Neuroinflammation

Simon W. M. John collaborates frequently with several co-authors, including Christa Montgomery, Revathi Balasubramanian, Nicholas Tolman, Krishnakumar Kizhatil, and Marina Simón. These collaborations have contributed to a robust academic output across multiple publications and specialized topics.

Their work is often published in venues such as bioRxiv (Cold Spring Harbor Laboratory) with 14 publications, eLife with 4, Investigative Ophthalmology & Visual Science with 3, Disease Models & Mechanisms with 2, and Nature Communications with 2 publications.

In addition to journal articles, Simon W. M. John has authored a book titled Medievalism in Nineteenth-Century Belgium, published in 2023 by Boydell and Brewer eBooks.

Best Publications

  • The classical complement cascade mediates CNS synapse elimination.

    Beth Stevens;Nicola J. Allen;Luis E. Vazquez;Gareth R. Howell

  • Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition

    Zhoutao Chen;Andrew C. Karaplis;Susan L. Ackerman;Igor P. Pogribny

  • Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma

    Gareth R. Howell;Richard T. Libby;Tatjana C. Jakobs;Richard S. Smith

  • Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice.

    Simon W M John;Richard S. Smith;Olga V. Savinova;Norman L. Hawes

  • Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly.

    Douglas B. Gould;F. Campbell Phalan;Guido J. Breedveld;Saskia E. van Mil

  • Role of COL4A1 in small-vessel disease and hemorrhagic stroke.

    Douglas B Gould;F Campbell Phalan;Saskia E van Mil;John P Sundberg

  • Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma

    Gareth R. Howell;Danilo G. Macalinao;Gregory L. Sousa;Michael Walden

  • Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice.

    Michael G Anderson;Richard S Smith;Norman L Hawes;Adriana Zabaleta

  • A rapid procedure for extracting genomic DNA from leukocytes

    S.W.M. John;G. Weitzner;R. Rozen;C.R. Scriver

  • Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

    Pete A. Williams;Jeffrey M. Harder;Nicole E. Foxworth;Kelly E. Cochran

  • Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration.

    Richard T. Libby;Michael G. Anderson;Iok-Hou Pang;Zachary H. Robinson

  • Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice

    Tatjana C. Jakobs;Richard T. Libby;Yixin Ben;Simon W.M. John

  • Susceptibility to Neurodegeneration in a Glaucoma Is Modified by Bax Gene Dosage

    Richard T Libby;Yan Li;Olga V Savinova;Joseph Barter

  • Under Pressure: Cellular and Molecular Responses During Glaucoma, a Common Neurodegeneration with Axonopathy

    Robert W. Nickells;Gareth R. Howell;Ileana Soto;Simon W.M. John

  • Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development

    Richard S. Smith;Adriana Zabaleta;Tsutomu Kume;Tsutomu Kume;Olga V. Savinova

  • Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice.

    Bo Chang;Richard S Smith;Norman L Hawes;Michael G Anderson

  • Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of Function.

    Byong Su Kim;Olga V. Savinova;Mark V. Reedy;Janice Martin

  • Glaucoma : Thinking in new ways-a rôle for autonomous axonal self-destruction and other compartmentalised processes?

    Alan V. Whitmore;Richard T. Libby;Simon W.M. John;Simon W.M. John

  • Distinct Target-Derived Signals Organize Formation, Maturation, and Maintenance of Motor Nerve Terminals

    Michael A. Fox;Joshua R. Sanes;Dorin Bogdan Borza;Veraragavan P. Eswarakumar

  • Modification of ocular defects in mouse developmental glaucoma models by tyrosinase.

    Richard T. Libby;Richard S. Smith;Olga V. Savinova;Adriana Zabaleta

Frequent Co-Authors

Gareth R. Howell
Gareth R. Howell The Jackson Laboratory
Abbot F. Clark
Abbot F. Clark University of North Texas Health Science Center
Bo Chang
Bo Chang University of California, Los Angeles
Janey L. Wiggs
Janey L. Wiggs Massachusetts Eye and Ear Infirmary
John R. Heckenlively
John R. Heckenlively University of Michigan–Ann Arbor
Muriel T. Davisson
Muriel T. Davisson University of California, Los Angeles
Chiea Chuen Khor
Chiea Chuen Khor Agency for Science, Technology and Research
Kathryn P. Burdon
Kathryn P. Burdon University of Tasmania
Alex W. Hewitt
Alex W. Hewitt University of Tasmania
Tin Aung
Tin Aung National University of Singapore

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Biology and Biochemistry in the USA can open the door to a wide range of allied health and science careers. Online education has made it easier than ever to access specialized programs related to biology and the medical field.

For students seeking to combine biological knowledge with technology and management, health information management online programs prepare graduates to manage patient data and healthcare technology. Those interested in nutrition and its biological impacts on health may pursue an online masters degree in nutrition to specialize in dietary science or wellness coaching.

Technical careers are also in demand. Students can earn industry-recognized certifications and degrees with flexible options such as ultrasound tech certification online or complete an online radiology tech programs to work in diagnostic imaging. These paths not only leverage a biology or biochemistry background but also help bridge the gap between classroom knowledge and practical healthcare applications.

Best Scientists Citing Simon W. M. John

Trending Scientists

Recently Published Articles