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Biology and Biochemistry

D-Index
86
Citations
21722
World Ranking
3040
National Ranking
1545

Overview

Abbot F. Clark is affiliated with the University of North Texas Health Science Center in the United States. Their research predominantly focuses on the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with significant contributions to ophthalmology and related disciplines.

Clark has an extensive publication record in the subfields of Ophthalmology, Molecular Biology, Radiology, Nuclear Medicine and Imaging, Cell Biology, and Pathology and Forensic Medicine. Their work primarily addresses topics such as glaucoma and retinal disorders, retinal development and diseases, corneal surgery and disorders, broader ophthalmology and eye disorders, as well as fibroblast growth factor and cell adhesion molecules research.

Prominent venues for Clark's publications include Investigative Ophthalmology & Visual Science, where they have published five papers, American Journal Of Pathology with three publications, alongside contributions in bioRxiv (Cold Spring Harbor Laboratory), Experimental Eye Research, and the International Journal of Molecular Sciences.

The recent papers authored or co-authored by Clark cover a range of glaucoma-related research:

  • CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma, 2020, Molecular Neurodegeneration
  • Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms, 2022, Investigative Ophthalmology & Visual Science
  • Role of Glucocorticoids and Glucocorticoid Receptors in Glaucoma Pathogenesis, 2023, Cells
  • The Canonical Wnt Signaling Pathway Inhibits the Glucocorticoid Receptor Signaling Pathway in the Trabecular Meshwork, 2021, American Journal Of Pathology
  • Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribrosa Cells in Glaucoma, 2022, Investigative Ophthalmology & Visual Science

Clark frequently collaborates with researchers such as J. Cameron Millar, Pinkal D. Patel, Gulab Zode, Gaurang Patel, and Balasankara Reddy Kaipa, indicating a network of partnerships primarily focused on ocular pathology and glaucoma research.

Best Publications

  • Identification of a Gene That Causes Primary Open Angle Glaucoma

    Edwin M. Stone;John H. Fingert;Wallace L. M. Alward;Thai D. Nguyen

  • Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma

    Gareth R. Howell;Danilo G. Macalinao;Gregory L. Sousa;Michael Walden

  • Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration.

    Richard T. Libby;Michael G. Anderson;Iok-Hou Pang;Zachary H. Robinson

  • Glucocorticoid-induced formation of cross-linked actin networks in cultured human trabecular meshwork cells

    A F Clark;K Wilson;M D McCartney;S T Miggans

  • TGFβ2-Induced Changes in Human Trabecular Meshwork: Implications for Intraocular Pressure

    Debra L. Fleenor;Allan R. Shepard;Peggy E. Hellberg;Nasreen Jacobson

  • Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor

    Nasreen Jacobson;Michael Andrews;Allan R. Shepard;Darryl Nishimura

  • Effects of glucocorticoids on the trabecular meshwork: towards a better understanding of glaucoma

    Robert J Wordinger;Abbot F Clark

  • Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma

    Gulab S. Zode;Markus H. Kuehn;Darryl Y. Nishimura;Charles C. Searby

  • Consensus recommendations for trabecular meshwork cell isolation, characterization and culture

    Kate E. Keller;Sanjoy K. Bhattacharya;Theresa Borrás;Thomas M. Brunner

  • The role of steroids in outflow resistance.

    Abbot F. Clark;Robert J. Wordinger

  • Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma

    Gareth R. Howell;Ileana Soto;Xianjun Zhu;Margaret Ryan

  • Noninvasive measurement of rodent intraocular pressure with a rebound tonometer.

    Wan Heng Wang;J. Cameron Millar;Iok Hou Pang;Martin B. Wax

  • Transforming Growth Factor–β Induces Extracellular Matrix Protein Cross-Linking Lysyl Oxidase (LOX) Genes in Human Trabecular Meshwork Cells

    Anirudh Sethi;Weiming Mao;Robert J. Wordinger;Abbot F. Clark

  • Effects of TGF-β2, BMP-4, and Gremlin in the Trabecular Meshwork: Implications for Glaucoma

    Robert J. Wordinger;Debra L. Fleenor;Peggy E. Hellberg;Iok Hou Pang

  • The effects of dexamethasone on fibronectin expression in cultured human trabecular meshwork cells.

    H T Steely;S L Browder;M B Julian;S T Miggans

  • Dexamethasone alters F‐actin architecture and promotes cross‐linked actin network formation in human trabecular meshwork tissue

    Abbot F. Clark;Daniel Brotchie;A. Thomas Read;Peggy Hellberg

  • The many faces of the trabecular meshwork cell.

    W. Daniel Stamer;Abbot F. Clark

  • Adenoviral Gene Transfer of Active Human Transforming Growth Factor-β2 Elevates Intraocular Pressure and Reduces Outflow Facility in Rodent Eyes

    Allan R. Shepard;J. Cameron Millar;Iok Hou Pang;Nasreen Jacobson

  • The effect of an angiostatic steroid on neovascularization in a rat model of retinopathy of prematurity.

    John S. Penn;Veeraramani S. Rajaratnam;Robert J. Collier;Abbot F. Clark

  • Dexamethasone-induced ocular hypertension in perfusion-cultured human eyes.

    A F Clark;K Wilson;A W de Kater;R R Allingham

Frequent Co-Authors

Edwin M. Stone
Edwin M. Stone University of Iowa
Val C. Sheffield
Val C. Sheffield University of Iowa
John H. Fingert
John H. Fingert University of Iowa
Simon W. M. John
Simon W. M. John Columbia University
Charles Searby
Charles Searby University of Iowa
John W. Crabb
John W. Crabb Cleveland Clinic
Todd E. Scheetz
Todd E. Scheetz University of Iowa
Gareth R. Howell
Gareth R. Howell The Jackson Laboratory
Robert F. Mullins
Robert F. Mullins University of Iowa
Beatrice Y.J.T. Yue
Beatrice Y.J.T. Yue University of Illinois at Chicago

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