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Biology and Biochemistry

D-Index
78
Citations
18793
World Ranking
4620
National Ranking
2244

Overview

John W. Crabb is a researcher affiliated with the Cleveland Clinic in the United States. Their work spans multiple disciplines within medicine and biochemistry, genetics, and molecular biology.

Their recent publications address several topics in molecular biology and medical research, with studies published in a variety of scientific journals. Key recent papers include:

  • Quantitative proteomic comparison of myofibroblasts derived from bone marrow and cornea, 2020, Scientific Reports
  • Proteomics of Primary Uveal Melanoma: Insights into Metastasis and Protein Biomarkers, 2021, Cancers
  • The pattern of apolipoprotein A-I lysine carbamylation reflects its lipidation state and the chemical environment within human atherosclerotic aorta, 2022, Journal of Biological Chemistry
  • Disease-specific platelet signaling defects in idiopathic pulmonary arterial hypertension, 2021, American Journal of Physiology-Lung Cellular and Molecular Physiology
  • The regulatory G protein signaling complex, Gβ5-R7, promotes glucose- and extracellular signal-stimulated insulin secretion, 2020, Journal of Biological Chemistry

Their collaborative efforts frequently involve coauthors such as Geeng-Fu Jang, Belinda Willard, Jack S Crabb, Allison Grenell, and Charandeep Singh.

John W. Crabb's research has appeared multiple times in these venues:

  • Journal of Biological Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports
  • Cancers
  • American Journal of Physiology-Lung Cellular and Molecular Physiology

Their main fields of study are Medicine and Biochemistry, Genetics and Molecular Biology, with subfields including Molecular Biology, Radiology, Nuclear Medicine and Imaging, Ophthalmology, Pulmonary and Respiratory Medicine, and Surgery.

Their scientific topics of focus are diverse and include:

  • Corneal Surgery and Treatments
  • Retinal Diseases and Treatments
  • Retinal Development and Disorders
  • Pancreatic function and diabetes
  • Receptor Mechanisms and Signaling
  • Proteoglycans and glycosaminoglycans research
  • Periodontal Regeneration and Treatments

Best Publications

  • Drusen proteome analysis: An approach to the etiology of age-related macular degeneration

    John W. Crabb;Masaru Miyagi;Xiaorong Gu;Karen Shadrach

  • An essential heparin-binding domain in the fibroblast growth factor receptor kinase

    Mikio Kan;Fen Wang;Jianming Xu;John W. Crabb

  • Paneth cell trypsin is the processing enzyme for human defensin-5

    Dipankar Ghosh;Edith Porter;Bo Shen;Sarah K. Lee

  • Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth.

    Elia J. Duh;Hoseong S. Yang;Izumi Suzuma;Masaru Miyagi

  • Proteomic method identifies proteins nitrated in vivo during inflammatory challenge

    Kulwant Singh Aulak;Masaru Miyagi;Lin Yan;Karen A. West

  • Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein

    Krzysztof Palczewski;Iswari Subbaraya;Wojciech A. Gorczyca;Bharati S. Helekar

  • Mutation of the gene encoding cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa.

    Marion A. Maw;Breandan Kennedy;Allison Knight;Robyn Bridges

  • Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration.

    Xiaorong Gu;Susan Gillette Meer;Masaru Miyagi;Mary E. Rayborn

  • Mechanism of Rhodopsin Kinase Activation

    Krzysztof Palczewski;Janina Buczylko;Michael W. Kaplan;Arthur S. Polans

  • Characterization of cDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence.

    Christopher Hassett;Rebecca J. Richter;Richard Humbert;Christine Chapline

  • Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line

    Jian Zhou;Guang Gao;John W Crabb;Ginette Serrero

  • A Photoreceptor Calcium Binding Protein Is Recognized by Autoantibodies Obtained from Patients with Cancer-associated Retinopathy

    Arthur S. Polans;Janina Buczyłko;John Crabb;Krzysztof Palczewski

  • Visual cycle impairment in cellular retinaldehyde binding protein (CRALBP) knockout mice results in delayed dark adaptation.

    John C. Saari;Maria Nawrot;Breandan N. Kennedy;Gregory G. Garwin

  • SOD2 knockdown mouse model of early AMD

    Verline Justilien;Ji-Jing Pang;Kutralanathan Renganathan;Xianquan Zhan

  • Dynamics of protein nitration in cells and mitochondria.

    Kulwant Singh Aulak;Thomas Koeck;John W Crabb;Dennis J Stuehr

  • Rapid and selective oxygen-regulated protein tyrosine denitration and nitration in mitochondria.

    Thomas Koeck;Xiaoming Fu;Stanley L. Hazen;John W. Crabb

  • Complete primary structure of prostatropin a prostate epithelial cell growth factor

    Crabb Jw;Armes Lg;Carr Sa;Johnson Cm

  • Molecular basis for the redox control of nuclear transport of the structural chromatin protein Hmgb1

    George B. Hoppe;Katherine E. Talcott;Sanjoy K. Bhattacharya;John W Crabb

  • Quantitative Proteomics: Comparison of the Macular Bruch Membrane/Choroid Complex from Age-related Macular Degeneration and Normal Eyes

    Xianglin Yuan;Xiaorong Gu;John S. Crabb;Xiuzhen Yue

  • Establishment and characterization of a retinal Müller cell line

    Vijay P. Sarthy;Sevan J. Brodjian;Kamla Dutt;Breandan N. Kennedy

Frequent Co-Authors

Robert G. Salomon
Robert G. Salomon Case Western Reserve University
Neal S. Peachey
Neal S. Peachey Cleveland Clinic
Krzysztof Palczewski
Krzysztof Palczewski University of California, Irvine
Belinda Willard
Belinda Willard Cleveland Clinic
Dennis J. Stuehr
Dennis J. Stuehr Cleveland Clinic Lerner College of Medicine
Wallace L. McKeehan
Wallace L. McKeehan Texas A&M Health Science Center
Michael E. Boulton
Michael E. Boulton University of Alabama at Birmingham
Jing Huang
Jing Huang Peking University
Timothy S. Kern
Timothy S. Kern University of California, Irvine
David C. Teller
David C. Teller University of Washington

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