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Biology and Biochemistry

D-Index
45
Citations
7675
World Ranking
19118
National Ranking
1305

Overview

Karl-Wilhelm Koch is affiliated with the Carl von Ossietzky University of Oldenburg in Germany. Their research spans areas primarily within biochemistry, genetics, molecular biology, and neuroscience, with a focus on molecular biology and cellular and molecular neuroscience as key subfields.

Their recent published works highlight investigations into cryptochrome proteins, retinal biology, and magnetoreception. Notable papers include:

  • "Magnetic sensitivity of cryptochrome 4 from a migratory songbird," 2021, published in Nature
  • "Protein-protein interaction of the putative magnetoreceptor cryptochrome 4 expressed in the avian retina," 2020, in Scientific Reports
  • "Direct Interaction of Avian Cryptochrome 4 with a Cone Specific G-Protein," 2022, in Cells
  • "The secrets of cryptochromes: photoreceptors, clock proteins, and magnetic sensors," 2021, in Neuroforum
  • "VISTA drives macrophages towards a pro-tumoral phenotype that promotes cancer cell phagocytosis yet down-regulates T cell responses," 2024, in Experimental Hematology and Oncology

Their publication venues most frequently include bioRxiv (Cold Spring Harbor Laboratory), Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, International Journal of Molecular Sciences, Biochemistry, and Scientific Reports.

Koch's main research topics encompass:

  • Retinal Development and Disorders
  • Retinal Diseases and Treatments
  • Photoreceptor and optogenetics research
  • Neurobiology and Insect Physiology Research
  • Cellular transport and secretion
  • Electromagnetic Fields and Biological Effects
  • Circadian rhythm and melatonin

Frequent collaborators include Henrik Mouritsen, Rabea Bartölke, Jessica Schmidt, Katharina Görtemaker, and Ilia A. Solov'yov, reflecting ongoing partnerships in advancing the understanding of molecular mechanisms related to sensory biology and cellular function.

Best Publications

  • Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ions

    Karl-Wilhelm Koch;Lubert Stryer

  • Magnetic sensitivity of cryptochrome 4 from a migratory songbird

    Jingjing Xu;Lauren E. Jarocha;Tilo Zollitsch;Marcin Konowalczyk

  • Frequenin—A novel calcium-binding protein that modulates synaptic efficacy in the drosophila nervous system

    O. Pongs;J. Lindemeier;X. R. Zhu;Thomas Theil

  • Role of cGMP and Ca2+ in Vertebrate Photoreceptor Excitation and Adaptation

    U B Kaupp;K W Koch

  • Cyclic GMP directly regulates a cation conductance in membranes of bovine rods by a cooperative mechanism.

    K W Koch;U B Kaupp

  • A 26 kd calcium binding protein from bovine rod outer segments as modulator of photoreceptor guanylate cyclase

    H. G. Lambrecht;K. W. Koch

  • Functional coupling of a Ca2+/calmodulin-dependent nitric oxide synthase and a soluble guanylyl cyclase in vertebrate photoreceptor cells.

    K.-W. Koch;H.-G. Lambrecht;M. Haberecht;D. Redburn

  • Purification and identification of photoreceptor guanylate cyclase.

    K W Koch

  • Double-Cone Localization and Seasonal Expression Pattern Suggest a Role in Magnetoreception for European Robin Cryptochrome 4

    Anja Günther;Angelika Einwich;Emil Sjulstok;Regina Feederle

  • Interaction of glutamic-acid-rich proteins with the cGMP signalling pathway in rod photoreceptors

    Heinz G. Körschen;Michael Beyermann;Frank Müller;Martin Heck

  • Functional Characterization of a Guanylyl Cyclase-activating Protein from Vertebrate Rods CLONING, HETEROLOGOUS EXPRESSION, AND LOCALIZATION

    Sandra Frins;Wolfgang Bönigk;Frank Müller;Roland Kellner

  • Calmodulin controls the rod photoreceptor CNG channel through an unconventional binding site in the N‐terminus of the β‐subunit

    Dietmar Weitz;Martin Zoche;Martin Zoche;Frank Müller;Michael Beyermann

  • Regulatory modes of rod outer segment membrane guanylate cyclase differ in catalytic efficiency and Ca2+‐sensitivity

    Ji-Young Hwang;Christian Lange;Andreas Helten;Doris Höppner-Heitmann

  • Calcium- and myristoyl-dependent properties of guanylate cyclase-activating protein-1 and protein-2.

    Ji-Young Hwang;Karl-Wilhelm Koch

  • Mutations in the GUCA1A gene involved in hereditary cone dystrophies impair calcium-mediated regulation of guanylate cyclase.

    Veronique B.D. Kitiratschky;Petra Behnen;Ulrich Kellner;John R. Heckenlively

  • Protein and Signaling Networks in Vertebrate Photoreceptor Cells

    Karl Wilhelm Koch;Daniele Dell'Orco

  • Solubilization and functional reconstitution of the cGMP-dependent cation channel from bovine rod outer segments

    N J Cook;C Zeilinger;K W Koch;U B Kaupp

  • Stereochemical course of the reaction catalyzed by guanylate cyclase from bovine retinal rod outer segments.

    K W Koch;F Eckstein;L Stryer

  • Glycosaminoglycan-binding properties and secondary structure of the C-terminus of netrin-1.

    Joachim Kappler;Joachim Kappler;Sebastian Franken;Ulrich Junghans;Ralf Hoffmann

  • Genotype-functional-phenotype correlations in photoreceptor guanylate cyclase (GC-E) encoded by GUCY2D.

    Dror Sharon;Hanna Wimberg;Yael Kinarty;Karl-Wilhelm Koch

Frequent Co-Authors

Michael Beyermann
Michael Beyermann Leibniz Association
Frank Müller
Frank Müller Forschungszentrum Jülich
Jose R. Naranjo
Jose R. Naranjo Spanish National Research Council
Michael R. Kreutz
Michael R. Kreutz Leibniz Institute for Neurobiology
Beat Schwaller
Beat Schwaller University of Fribourg
U. Benjamin Kaupp
U. Benjamin Kaupp University of Bonn
Samuel G. Jacobson
Samuel G. Jacobson University of Pennsylvania
Jaume Bertranpetit
Jaume Bertranpetit Pompeu Fabra University
Alexander M. Dizhoor
Alexander M. Dizhoor Salus University
Sara Linse
Sara Linse Lund University

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