World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
76
Citations
21855
World Ranking
5023
National Ranking
2412

Research.com Recognitions

  • 1989 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1984 - Troland Research Awards, United States National Academy of Sciences For his distinguished, quantitative psychophysical work on mechanisms of color adaptation and to encourage his physiological work on mechanisms of receptor transduction and sensitivity control.

Overview

Edward N. Pugh is affiliated with the University of California, Davis in the United States. Their research spans multiple fields within medicine and biochemistry, genetics, and molecular biology, with a focus on ocular and molecular neuroscience topics.

Their main fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these fields, their subfields of study are:

  • Molecular Biology
  • Ophthalmology
  • Cellular and Molecular Neuroscience
  • Radiology, Nuclear Medicine and Imaging
  • Biomedical Engineering

Edward N. Pugh's research covers several specific topics, including:

  • Retinal Development and Disorders
  • Retinal Diseases and Treatments
  • Glaucoma and retinal disorders
  • Photoreceptor and optogenetics research
  • Bioluminescence and chemiluminescence research
  • Optical Coherence Tomography Applications
  • Corneal surgery and disorders

The scientist is a frequent contributor to several publication venues, particularly in the fields of vision science and physiology. These venues include:

  • Investigative Ophthalmology & Visual Science
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports
  • Proceedings of the National Academy of Sciences
  • The Journal of General Physiology

Notable recent papers authored by Edward N. Pugh are:

  • "In vivo multimodal retinal imaging of disease-related pigmentary changes in retinal pigment epithelium," 2021, Scientific Reports
  • "Measurement of Diurnal Variation in Rod Outer Segment Length In Vivo in Mice With the OCT Optoretinogram," 2020, Investigative Ophthalmology & Visual Science
  • "Human cone elongation responses can be explained by photoactivated cone opsin and membrane swelling and osmotic response to phosphate produced by RGS9-catalyzed GTPase," 2022, Proceedings of the National Academy of Sciences
  • "In Situ Morphologic and Spectral Characterization of Retinal Pigment Epithelium Organelles in Mice Using Multicolor Confocal Fluorescence Imaging," 2020, Investigative Ophthalmology & Visual Science
  • "Loss of the K+ channel Kv2.1 greatly reduces outward dark current and causes ionic dysregulation and degeneration in rod photoreceptors," 2021, The Journal of General Physiology

Throughout their career, Edward N. Pugh has collaborated frequently with several researchers, including:

  • Marie E. Burns
  • Robert J. Zawadzki
  • Ratheesh K. Meleppat
  • Kaitryn E. Ronning
  • Sarah J. Karlen

Edward N. Pugh has been recognized with several awards, including being named a Fellow of the American Association for the Advancement of Science (AAAS) in 1989. Additionally, they received the Troland Research Award from the United States National Academy of Sciences in 1984, which highlighted their quantitative psychophysical work on color adaptation mechanisms and physiological research on receptor transduction and sensitivity control.

Best Publications

  • Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

    Albert M. Maguire;Francesca Simonelli;Eric A. Pierce;Edward N. Pugh

  • G proteins and phototransduction.

    Vadim Y. Arshavsky;Trevor D. Lamb;Edward N. Pugh

  • Dark adaptation and the retinoid cycle of vision.

    Trevor Lamb;Edward N Pugh

  • Amplification and kinetics of the activation steps in phototransduction

    Edward N Pugh;T. D. Lamb

  • A quantitative account of the activation steps involved in phototransduction in amphibian photoreceptors.

    T. D. Lamb;Edward N Pugh

  • Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup

    Trevor D. Lamb;Shaun P. Collin;Edward N. Pugh

  • Chapter 5 Phototransduction in vertebrate rods and cones: Molecular mechanisms of amplification, recovery and light adaptation

    Edward N Pugh;T. D. Lamb

  • Massive light-driven translocation of transducin between the two major compartments of rod cells: A novel mechanism of light adaptation

    Maxim Sokolov;Arkady L. Lyubarsky;Katherine J. Strissel;Andrey B. Savchenko

  • The Proteome of the Mouse Photoreceptor Sensory Cilium Complex

    Qin Liu;Glenn Tan;Natasha Levenkova;Tiansen Li

  • Phototransduction in transgenic mice after targeted deletion of the rod transducin α-subunit

    P. D. Calvert;N. V. Krasnoperova;A. L. Lyubarsky;A. L. Lyubarsky;T. Isayama

  • Molecular mechanisms of vertebrate photoreceptor light adaptation.

    Edward N Pugh;S. Nikonov;T. D. Lamb

  • Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings

    Sergei S. Nikonov;Roman Kholodenko;Janis Lem;Edward N. Pugh

  • Phototransduction, dark adaptation, and rhodopsin regeneration : The proctor lecture

    Trevor D. Lamb;Edward N. Pugh

  • UV- and midwave-sensitive cone-driven retinal responses of the mouse: a possible phenotype for coexpression of cone photopigments.

    A. L. Lyubarsky;B. Falsini;M. E. Pennesi;P. Valentini

  • Cyclic GMP and calcium: the internal messengers of excitation and adaptation in vertebrate photoreceptors.

    Edward N Pugh;T. D. Lamb

  • The control of phosphodiesterase in rod disk membranes: kinetics, possible mechanisms and significance for vision.

    P. A. Liebman;Edward N Pugh

  • Polarization-difference imaging: a biologically inspired technique for observation through scattering media.

    M. P. Rowe;Edward N Pugh;J. S. Tyo;N. Engheta

  • The Gain of Rod Phototransduction: Reconciliation of Biochemical and Electrophysiological Measurements

    Ilya B. Leskov;Vadim A. Klenchin;Jason W. Handy;Gary G. Whitlock

  • ATP mediates rapid reversal of cyclic GMP phosphodiesterase activation in visual receptor membranes

    P. A. Liebman;Edward N Pugh

  • The Proteome of the Mouse Photoreceptor Sensory Cilium

    Glenn Tan;Edward N. Pugh;David W. Speicher;Eric A. Pierce

Frequent Co-Authors

Nader Engheta
Nader Engheta University of Pennsylvania
Eric A. Pierce
Eric A. Pierce Massachusetts Eye and Ear Infirmary
Kit S. Lam
Kit S. Lam University of California, Davis
Vadim Y. Arshavsky
Vadim Y. Arshavsky Duke University
Jean Bennett
Jean Bennett University of Pennsylvania
Anand Swaroop
Anand Swaroop National Institutes of Health
Cheryl M. Craft
Cheryl M. Craft University of Southern California
Albert M. Maguire
Albert M. Maguire University of Pennsylvania
Wolfgang Baehr
Wolfgang Baehr University of Utah
Samuel G. Jacobson
Samuel G. Jacobson University of Pennsylvania

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