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Genetics

D-Index
64
Citations
20821
World Ranking
2761
National Ranking
1214

Overview

Eric A. Pierce is affiliated with the Massachusetts Eye and Ear Infirmary in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Within these broad disciplines, their work focuses on subfields including Molecular Biology, Genetics, Ophthalmology, Physiology, and Cellular and Molecular Neuroscience.

The scientific topics explored by Eric A. Pierce center around Retinal Development and Disorders, Retinal Diseases and Treatments, and Genomics and Rare Diseases. Additional areas of study include Genomic variations and chromosomal abnormalities, RNA regulation and disease, Virus-based gene therapy research, and advanced biosensing and bioanalysis techniques.

Eric A. Pierce has published extensively, including recent notable papers such as:

  • "Genome Sequencing for Diagnosing Rare Diseases," 2024, New England Journal of Medicine
  • "Copy-number variation contributes 9% of pathogenicity in the inherited retinal degenerations," 2020, Genetics in Medicine
  • "Investigating cone photoreceptor development using patient-derived NRL null retinal organoids," 2020, Communications Biology
  • "Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium," 2020, Translational Vision Science & Technology
  • "Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy," 2020, The American Journal of Human Genetics

Their collaborations include frequent co-authors such as Kinga M. Bujakowska, Emily Place, Rachel M. Huckfeldt, Jason Comander, and Riccardo Sangermano.

Eric A. Pierce has contributed to multiple scientific publications across various venues. These include bioRxiv (Cold Spring Harbor Laboratory) where they have 17 publications, Genetics in Medicine with 4 publications, Human Molecular Genetics with 4 publications, The American Journal of Human Genetics with 3, and Molecular Case Studies also with 3 publications.

Best Publications

  • Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

    Albert M. Maguire;Francesca Simonelli;Eric A. Pierce;Edward N. Pugh

  • Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins

    Lloyd Paul Aiello;Eric A. Pierce;Eliot D. Foley;Hitoshi Takagi

  • Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization

    Eric Adam Pierce;R. L. Avery;E. D. Foley;Lloyd Paul Aiello

  • Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial

    Albert M. Maguire;Albert M. Maguire;Katherine A. High;Katherine A. High;Alberto Auricchio;J. Fraser Wright;J. Fraser Wright

  • Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration.

    Francesca Simonelli;Albert M Maguire;Albert M Maguire;Francesco Testa;Eric A Pierce

  • Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity

    Eric A. Pierce;Eliot D. Foley;Lois E. H. Smith

  • Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial

    Jean Bennett;Jean Bennett;Jennifer Wellman;Kathleen A Marshall;Sarah McCague

  • AAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness

    Jean Bennett;Jean Bennett;Manzar Ashtari;Jennifer Wellman;Kathleen A. Marshall

  • Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy

    Gregory S. Robinson;Eric A. Pierce;Susan L. Rook;Elliot Foley

  • Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease.

    M. C. Dinauer;E. A. Pierce;G. A. P. Bruns;J. T. Curnutte

  • Comparative analysis of RNA-Seq alignment algorithms and the RNA-Seq unified mapper (RUM)

    Gregory R. Grant;Michael H. Farkas;Angel D. Pizarro;Nicholas F. Lahens

  • TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum

    Erica E. Davis;Qi Zhang;Qin Liu;Bill H. Diplas

  • The Proteome of the Mouse Photoreceptor Sensory Cilium Complex

    Qin Liu;Glenn Tan;Natasha Levenkova;Tiansen Li

  • Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy

    Edgar A Otto;Toby W Hurd;Rannar Airik;Moumita Chaki

  • Three-Year Follow-up after Unilateral Subretinal Delivery of Adeno-Associated Virus in Patients with Leber Congenital Amaurosis Type 2

    Francesco Testa;Albert M. Maguire;Albert M. Maguire;Settimio Rossi;Eric A. Pierce

  • Specific Double-Stranded RNA Interference in Undifferentiated Mouse Embryonic Stem Cells

    Shicheng Yang;Stephen Tutton;Eric Pierce;Kyonggeun Yoon

  • Panel-based genetic diagnostic testing for inherited eye diseases is highly accurate and reproducible, and more sensitive for variant detection, than exome sequencing

    Mark B. Consugar;Daniel Navarro-Gomez;Emily M. Place;Kinga M. Bujakowska

  • Mutations in a gene encoding a new oxygen-regulated photoreceptor protein cause dominant retinitis pigmentosa

    Eric A. Pierce;Tracey Quinn;Terrence Meehan;Terri L. McGee

  • Mutations in TSPAN12 Cause Autosomal-Dominant Familial Exudative Vitreoretinopathy

    James A. Poulter;Manir Ali;David F. Gilmour;Aine Rice

  • The Proteome of the Mouse Photoreceptor Sensory Cilium

    Glenn Tan;Edward N. Pugh;David W. Speicher;Eric A. Pierce

Frequent Co-Authors

Xiaowu Gai
Xiaowu Gai Children's Hospital of Los Angeles
Jean Bennett
Jean Bennett University of Pennsylvania
Stephen P. Daiger
Stephen P. Daiger The University of Texas Health Science Center at Houston
Chris F. Inglehearn
Chris F. Inglehearn University of Leeds
Albert M. Maguire
Albert M. Maguire University of Pennsylvania
Shomi S. Bhattacharya
Shomi S. Bhattacharya University College London
Katherine A. High
Katherine A. High Children's Hospital of Philadelphia
Hector F. DeLuca
Hector F. DeLuca University of Wisconsin–Madison
Nicholas Katsanis
Nicholas Katsanis Galatea Bio Inc
Edwin M. Stone
Edwin M. Stone University of Iowa

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