His primary areas of investigation include Genetics, Retinal, Cis-trans-Isomerases, Ophthalmology and Retinal degeneration. His work deals with themes such as Neovascularization, Retinopathy, Immunology, Vascular endothelial growth factor A and Retina, which intersect with Retinal. Cis-trans-Isomerases is connected with RPE65 and Genetic enhancement in his study.
His research ties Leber's congenital amaurosis and RPE65 together. Eric A. Pierce works on Ophthalmology which deals in particular with Visual acuity. His Retinal degeneration study incorporates themes from Exome sequencing and Cell biology.
Eric A. Pierce mainly focuses on Genetics, Cell biology, Retinitis pigmentosa, Retinal and Retinal degeneration. He works mostly in the field of Cell biology, limiting it down to topics relating to Complement system and, in certain cases, Macular degeneration. His studies in Retinitis pigmentosa integrate themes in fields like Exome sequencing, Missense mutation and Splicing factor, RNA splicing.
His Retinal research is multidisciplinary, relying on both Retina, Computational biology and Genetic enhancement. His research in Retinal degeneration intersects with topics in Dystrophy and NMNAT1. His work on RPE65 and Electroretinography as part of general Ophthalmology study is frequently linked to Cis-trans-Isomerases, bridging the gap between disciplines.
Eric A. Pierce mainly investigates Genetics, Retinitis pigmentosa, Gene, Cell biology and Retinal. CRISPR, Retinal degeneration, Rod-cone dystrophy, Ciliopathy and Mutation are the subjects of his Genetics studies. His Retinitis pigmentosa study integrates concerns from other disciplines, such as Regulator, Rod Photoreceptors and Genetic enhancement.
His Gene study combines topics from a wide range of disciplines, such as Phase i ii and Pathology. Eric A. Pierce works mostly in the field of Cell biology, limiting it down to concerns involving Mutant and, occasionally, Extracellular matrix, Matrix metalloproteinase, Complement system and Complement component 5. His Retinal research integrates issues from Dystrophy, Retina and MEF2C.
His primary scientific interests are in Genetics, Retinitis pigmentosa, Gene, Retinal and Retina. The Retinitis pigmentosa study combines topics in areas such as KIFAP3, KIF3A, Kinesin, Genetic enhancement and Ciliopathy. The Genetic enhancement study combines topics in areas such as Retinal degeneration, Computational biology and Induced pluripotent stem cell.
Eric A. Pierce has included themes like Downregulation and upregulation and Cell biology in his Retinal study. His Cell biology research includes themes of Retinal pigment epithelium, PRPF31, Rod Photoreceptors and Haploinsufficiency. The study incorporates disciplines such as Phenotype, Cancer research and Transgene in addition to Retina.
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Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis
Albert M. Maguire;Francesca Simonelli;Eric A. Pierce;Edward N. Pugh.
The New England Journal of Medicine (2008)
Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins
Lloyd Paul Aiello;Eric A. Pierce;Eliot D. Foley;Hitoshi Takagi.
Proceedings of the National Academy of Sciences of the United States of America (1995)
Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization
Eric Adam Pierce;R. L. Avery;E. D. Foley;Lloyd Paul Aiello.
Proceedings of the National Academy of Sciences of the United States of America (1995)
Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial
Albert M. Maguire;Albert M. Maguire;Katherine A. High;Katherine A. High;Alberto Auricchio;J. Fraser Wright;J. Fraser Wright.
The Lancet (2009)
Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration.
Francesca Simonelli;Albert M Maguire;Albert M Maguire;Francesco Testa;Eric A Pierce.
Molecular Therapy (2010)
Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity
Eric A. Pierce;Eliot D. Foley;Lois E. H. Smith.
Archives of Ophthalmology (1996)
Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy
Gregory S. Robinson;Eric A. Pierce;Susan L. Rook;Elliot Foley.
Proceedings of the National Academy of Sciences of the United States of America (1996)
Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease.
M. C. Dinauer;E. A. Pierce;G. A. P. Bruns;J. T. Curnutte.
Journal of Clinical Investigation (1990)
AAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness
Jean Bennett;Jean Bennett;Manzar Ashtari;Jennifer Wellman;Kathleen A. Marshall.
Science Translational Medicine (2012)
Specific Double-Stranded RNA Interference in Undifferentiated Mouse Embryonic Stem Cells
Shicheng Yang;Stephen Tutton;Eric Pierce;Kyonggeun Yoon.
Molecular and Cellular Biology (2001)
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