World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
101
Citations
36046
World Ranking
1447
National Ranking
823

Medicine

D-Index
108
Citations
42366
World Ranking
6009
National Ranking
3215

Research.com Recognitions

  • 2015 - The Llura Liggett Gund Award, Foundation Fighting Blindness for his work on vision-saving treatments and cures.
  • 2006 - Grand Prix scientifique de la Fondation NRJ, Institut de France
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

José-Alain Sahel is affiliated with the University of Pittsburgh in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a specific focus on Ophthalmology, Molecular Biology, and Cellular and Molecular Neuroscience. Their work also intersects with Radiology, Nuclear Medicine and Imaging, and Biomedical Engineering.

Their research topics cover a broad range of areas related to vision and retinal science, including:

  • Retinal Development and Disorders
  • Retinal Diseases and Treatments
  • Retinal Imaging and Analysis
  • Glaucoma and retinal disorders
  • Photoreceptor and optogenetics research
  • Retinal and Optic Conditions
  • Neuroscience and Neural Engineering

José-Alain Sahel has contributed to publications in several venues, with frequent contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports
  • American Journal of Ophthalmology
  • International Journal of Molecular Sciences
  • Translational Vision Science & Technology

Notable recent papers authored or co-authored by Sahel include:

  • "Partial recovery of visual function in a blind patient after optogenetic therapy", 2021, Nature Medicine
  • "Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy", 2020, Science Translational Medicine
  • "Photovoltaic Restoration of Central Vision in Atrophic Age-Related Macular Degeneration", 2020, Ophthalmology
  • "Early and late stage gene therapy interventions for inherited retinal degenerations", 2021, Progress in Retinal and Eye Research
  • "Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD", 2022, Autophagy

Their frequent scientific collaborators include Isabelle Audo, Jay Chhablani, Christina Zeitz, Serge Picaud, and Magali Taiel.

José-Alain Sahel's work has been recognized with awards such as The Llura Liggett Gund Award from the Foundation Fighting Blindness in 2015, awarded for work on vision-saving treatments and cures, as well as the Grand Prix scientifique de la Fondation NRJ from the Institut de France in 2006. They are also a member of the Association of American Physicians.

Best Publications

  • A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

    Lars G. Fritsche;Wilmar Igl;Jessica N.Cooke Bailey;Felix Grassmann

  • Seven new loci associated with age-related macular degeneration

    Lars G. Fritsche;Lars G. Fritsche;Wei Chen;Wei Chen;Matthew Schu;Brian L. Yaspan

  • Interim Results from the International Trial of Second Sight's Visual Prosthesis

    Mark S. Humayun;Jessy D. Dorn;Lyndon Da Cruz;Gislin Dagnelie

  • Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa

    Volker Busskamp;Jens Duebel;David Balya;Mathias Fradot;Mathias Fradot;Mathias Fradot

  • Partial recovery of visual function in a blind patient after optogenetic therapy

    José-Alain Sahel;Elise Boulanger-Scemama;Chloé Pagot;Angelo Arleo

  • Identification and characterization of rod-derived cone viability factor.

    Léveillard T;Mohand-Saïd S;Lorentz O;Hicks D

  • The Argus II epiretinal prosthesis system allows letter and word reading and long-term function in patients with profound vision loss

    Lyndon da Cruz;Brian F Coley;Jessy Dorn;Francesco Merlini

  • Five-Year Safety and Performance Results from the Argus II Retinal Prosthesis System Clinical Trial

    Lyndon da Cruz;Jessy D. Dorn;Mark S. Humayun;Gislin Dagnelie

  • Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis.

    Najate Aït-Ali;Najate Aït-Ali;Najate Aït-Ali;Ram Fridlich;Ram Fridlich;Ram Fridlich;Géraldine Millet-Puel;Géraldine Millet-Puel;Géraldine Millet-Puel;Emmanuelle Clérin;Emmanuelle Clérin;Emmanuelle Clérin

  • From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium

    Sacha Reichman;Angélique Terray;Amélie Slembrouck;Céline Nanteau

  • CCR2+ monocytes infiltrate atrophic lesions in age‐related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice

    Florian Sennlaub;Constance Auvynet;Constance Auvynet;Bertrand Calippe;Sophie Lavalette

  • Effect of autologous platelet concentrate in surgery for idiopathic macular hole: results of a multicenter, double-masked, randomized trial. Platelets in Macular Hole Surgery Group.

    Michel Paques;Claude Chastang;André Mathis;José Sahel

  • Long-Term Results from an Epiretinal Prosthesis to Restore Sight to the Blind

    Allen C. Ho;Mark S. Humayun;Jessy D. Dorn;Lyndon Da Cruz

  • Optogenetic therapy for retinitis pigmentosa.

    V Busskamp;S Picaud;J A Sahel;B Roska

  • TRPM1 Is Mutated in Patients with Autosomal-Recessive Complete Congenital Stationary Night Blindness

    Isabelle Audo;Susanne Kohl;Bart P. Leroy;Francis L. Munier

  • Optimized Allotopic Expression of the Human Mitochondrial ND4 Prevents Blindness in a Rat Model of Mitochondrial Dysfunction

    Sami Ellouze;Sébastien Augustin;Aicha Bouaita;Crystel Bonnet

  • Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse

    Saddek Mohand-Said;Alain Deudon-Combe;David Hicks;Manuel Simonutti

  • Case-control study of the risk factors for age related macular degeneration

    G Chaine;A Hullo;J Sahel;G Soubrane

  • Clinical Characteristics and Current Therapies for Inherited Retinal Degenerations

    Jose ´ Alain Sahel;Katia Marazova;Isabelle Audo

  • Foveal shape and structure in a normal population.

    Sarah Tick;Florence Rossant;Itebeddine Ghorbel;Alain Gaudric

Frequent Co-Authors

Serge Picaud
Serge Picaud Institut de la Vision
Thierry Léveillard
Thierry Léveillard Institut de la Vision
Florian Sennlaub
Florian Sennlaub Institut de la Vision
Deniz Dalkara
Deniz Dalkara Inserm : Institut national de la santé et de la recherche médicale
Shomi S. Bhattacharya
Shomi S. Bhattacharya University College London
Mathias Fink
Mathias Fink ESPCI Paris
Olivier Poch
Olivier Poch University of Strasbourg
Ryad Benosman
Ryad Benosman University of Pittsburgh
Hélène Dollfus
Hélène Dollfus University of Strasbourg
Eberhart Zrenner
Eberhart Zrenner University of Tübingen

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing José-Alain Sahel

Trending Scientists