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Genetics

D-Index
59
Citations
9804
World Ranking
3269
National Ranking
397

Overview

Michal Minczuk is affiliated with the University of Cambridge in the United Kingdom. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a significant body of work in mitochondrial function and pathology.

The scientist has contributed extensively to subfields such as molecular biology, clinical biochemistry, spectroscopy, cancer research, and genetics. Their research covers key topics including mitochondrial function and pathology, RNA modifications and cancer, RNA and protein synthesis mechanisms, CRISPR and genetic engineering, metabolism and genetic disorders, ATP synthase and ATPases research, and genomics and phylogenetic studies.

Michal Minczuk's recent papers include:

  • The potential of mitochondrial genome engineering (2021, Nature Reviews Genetics)
  • Elongational stalling activates mitoribosome-associated quality control (2020, Science)
  • Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs (2021, Molecular Cell)
  • TRMT2B is responsible for both tRNA and rRNA m5U-methylation in human mitochondria (2020, RNA Biology)
  • In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue (2022, Nature Communications)

The frequent co-authors who have collaborated with Michal Minczuk are Lindsey Van Haute, Pedro Silva-Pinheiro, Christopher A. Powell, Christian D. Mutti, and Maria Falkenberg.

Publishing regularly in notable scientific venues, Michal Minczuk has several contributions in Nature Communications and bioRxiv (Cold Spring Harbor Laboratory), along with publications in Nucleic Acids Research, Molecular Cell, and RNA Biology.

In addition to journal articles, Michal Minczuk has contributed to book publications, including the title "Mitochondrial Gene Expression" published by Springer Science+Business Media in 2020.

Best Publications

  • In D-loop: 40 years of mitochondrial 7S DNA.

    Thomas J. Nicholls;Michal Minczuk

  • Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations

    Payam A Gammage;Joanna Rorbach;Anna I Vincent;Edward J Rebar

  • Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized

    Payam A. Gammage;Carlos T. Moraes;Michal Minczuk

  • Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo.

    Payam A. Gammage;Carlo Viscomi;Marie-Lune Simard;Ana S. H. Costa

  • Mitochondrial transcription and translation: overview.

    Aaron R. D’Souza;Michal Minczuk

  • Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease

    Cornelia Kornblum;Thomas J Nicholls;Tobias B Haack;Susanne Schöler

  • Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA

    Michal Minczuk;Monika A. Papworth;Jeffrey C. Miller;Michael P. Murphy

  • Deficient methylation and formylation of mt-tRNA Met wobble cytosine in a patient carrying mutations in NSUN3

    Lindsey Van Haute;Sabine Dietmann;Laura Kremer;Shobbir Hussain

  • NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction.

    Edoardo Gaude;Christina Schmidt;Payam A Gammage;Aurelien Dugourd

  • TEFM (c17orf42) is necessary for transcription of human mtDNA

    Michal Minczuk;Jiuya He;Anna M. Duch;Thijs J. Ettema

  • Regulation of Mammalian Mitochondrial Gene Expression: Recent Advances

    Sarah F. Pearce;Pedro Rebelo-Guiomar;Pedro Rebelo-Guiomar;Aaron R. D’Souza;Christopher A. Powell

  • Linear mitochondrial DNA is rapidly degraded by components of the replication machinery

    Viktoriya Peeva;Daniel Blei;Genevieve Trombly;Sarah Corsi;Sarah Corsi

  • Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase

    Michal Minczuk;Monika A. Papworth;Paulina Kolasinska;Michael P. Murphy

  • Designer zinc-finger proteins and their applications

    Monika Papworth;Paulina Kolasinska;Paulina Kolasinska;Michal Minczuk;Michal Minczuk

  • The yeast mitochondrial degradosome. Its composition, interplay between RNA helicase and RNase activities and the role in mitochondrial RNA metabolism.

    Andrzej Dziembowski;Jan Piwowarski;Rafal Hoser;Michal Minczuk

  • Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes

    Fuyang Li;Monika Papworth;Michal Minczuk;Christian Rohde

  • ELAC2 Mutations Cause a Mitochondrial RNA Processing Defect Associated with Hypertrophic Cardiomyopathy

    Tobias B. Haack;Robert Kopajtich;Peter Freisinger;Thomas Wieland

  • Mutations in GTPBP3 Cause a Mitochondrial Translation Defect Associated with Hypertrophic Cardiomyopathy, Lactic Acidosis, and Encephalopathy

    Robert Kopajtich;Thomas J. Nicholls;Joanna Rorbach;Metodi D. Metodiev

  • The post-transcriptional life of mammalian mitochondrial RNA

    Joanna Rorbach;Michal Minczuk

  • Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors

    Monika Papworth;Michael Moore;Mark Isalan;Michal Minczuk

Frequent Co-Authors

Patrick F. Chinnery
Patrick F. Chinnery University of Cambridge
Holger Prokisch
Holger Prokisch Technical University of Munich
Massimo Zeviani
Massimo Zeviani University of Padua
Vamsi K. Mootha
Vamsi K. Mootha Harvard Medical School
Sarah E. Calvo
Sarah E. Calvo Broad Institute
Thomas Meitinger
Thomas Meitinger Technical University of Munich
Salvatore DiMauro
Salvatore DiMauro Columbia University
David W. Ray
David W. Ray University of Oxford
Robert W. Taylor
Robert W. Taylor Newcastle University

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