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Robert N. Lightowlers

Robert N. Lightowlers

D-Index & Metrics

Genetics

D-Index
75
Citations
21231
World Ranking
1898
National Ranking
240

Overview

Robert N. Lightowlers is a researcher affiliated with Newcastle University in the United Kingdom. Their work primarily falls within the field of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology as a subfield. Additional areas of study include Clinical Biochemistry, Genetics, Cellular and Molecular Neuroscience, and Surgery.

Their research covers several main topics, notably:

  • Mitochondrial Function and Pathology
  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • Metabolism and Genetic Disorders
  • ATP Synthase and ATPases Research
  • Bacterial Genetics and Biotechnology
  • Genetic Neurodegenerative Diseases

Recent papers authored or co-authored by Robert N. Lightowlers include:

  • "Mitochondrial transplantation-a possible therapeutic for mitochondrial dysfunction?" (2020, EMBO Reports)
  • "High-resolution imaging reveals compartmentalization of mitochondrial protein synthesis in cultured human cells" (2021, Proceedings of the National Academy of Sciences)
  • "Rescuing stalled mammalian mitoribosomes - what can we learn from bacteria?" (2020, Journal of Cell Science)
  • "Messenger RNA delivery to mitoribosomes - hints from a bacterial toxin" (2020, FEBS Journal)
  • "Mitochondrial Diseases: Hope for the Future" (2020, Cell; authored by Oliver M. Russell, but appearing in frequent co-author lists)

The frequent co-authors collaborating with Robert N. Lightowlers include:

  • Zofia M. Chrzanowska-Lightowlers
  • Rolando Berlinguer-Palmini
  • Matthew Zorkau
  • Christin A. Albus
  • Oliver M. Russell

Common publication venues for their work are:

  • Methods in molecular biology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell
  • EMBO Reports
  • Proceedings of the National Academy of Sciences

Best Publications

  • Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA

    Richard M. Andrews;Iwona Kubacka;Patrick F. Chinnery;Robert N. Lightowlers

  • Mammalian mitochondrial genetics: heredity, heteroplasmy and disease

    Robert N. Lightowlers;Patrick F. Chinnery;Douglass M. Turnbull;Neil Howell

  • Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease

    Lyndsey Craven;Helen A. Tuppen;Gareth D. Greggains;Stephen J. Harbottle

  • What causes mitochondrial DNA deletions in human cells

    Kim J Krishnan;Amy K Reeve;David C Samuels;Patrick F Chinnery

  • Molecular pathology of MELAS and MERRF. The relationship between mutation load and clinical phenotypes.

    Patrick F. Chinnery;Neil Howell;Robert N. Lightowlers;Douglass M. Turnbull

  • PNPASE Regulates RNA Import into Mitochondria

    Geng Wang;Hsiao-Wen Chen;Yavuz Oktay;Jin Zhang

  • Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle.

    Elizabeth J. Brierley;Margaret A. Johnson;Robert N. Lightowlers;Oliver F. W. James

  • Mutations causing mitochondrial disease: What is new and what challenges remain?

    Robert N. Lightowlers;Robert W. Taylor;Doug M. Turnbull

  • Selective inhibition of mutant human mitochondrial DNA replication in vitro by peptide nucleic acids

    Robert W. Taylor;Patrick F. Chinnery;Douglass M. Turnbull;Robert N. Lightowlers

  • Mitochondrial Diseases: Hope for the Future

    Oliver M. Russell;Gráinne S. Gorman;Robert N. Lightowlers;Doug M. Turnbull

  • The inheritance of mitochondrial DNA heteroplasmy: random drift, selection or both?

    Patrick F Chinnery;David R Thorburn;David C Samuels;Sarah L White

  • Human mitochondrial mRNAs--like members of all families, similar but different.

    Richard J. Temperley;Mateusz Wydro;Robert N. Lightowlers;Zofia M. Chrzanowska-Lightowlers

  • GRSF1 Regulates RNA Processing in Mitochondrial RNA Granules

    Alexis A. Jourdain;Mirko Koppen;Mateusz Wydro;Chris D. Rodley

  • Targeting peptide nucleic acid (PNA) oligomers to mitochondria within cells by conjugation to lipophilic cations: implications for mitochondrial DNA replication, expression and disease

    Aleksandra Muratovska;Robert N Lightowlers;Robert W Taylor;Douglass M Turnbull

  • Mismatch repair activity in mammalian mitochondria

    Penelope A. Mason;Elizabeth C. Matheson;Andrew G. Hall;Robert N. Lightowlers

  • Peptide nucleic acid delivery to human mitochondria

    P F Chinnery;R W Taylor;K Diekert;R Lill

  • Hungry codons promote frameshifting in human mitochondrial ribosomes.

    Richard Temperley;Ricarda Richter;Sven Dennerlein;Robert N. Lightowlers

  • DNA repair in organelles: Pathways, organization, regulation, relevance in disease and aging.

    Pierre Boesch;Frédérique Weber-Lotfi;Noha Ibrahim;Vladislav Tarasenko

  • Nuclear DNA-encoded tRNAs targeted into mitochondria can rescue a mitochondrial DNA mutation associated with the MERRF syndrome in cultured human cells

    Olga A. Kolesnikova;Nina S. Entelis;Clarisse Jacquin-Becker;Francine Goltzene

  • Abnormal RNA processing associated with a novel tRNA mutation in mitochondrial DNA. A potential disease mechanism.

    L A Bindoff;N Howell;J Poulton;D A McCullough

Frequent Co-Authors

Douglass M. Turnbull
Douglass M. Turnbull Newcastle University
Robert W. Taylor
Robert W. Taylor Newcastle University
Patrick F. Chinnery
Patrick F. Chinnery University of Cambridge
Robert McFarland
Robert McFarland Newcastle University
Neil Howell
Neil Howell The University of Texas Medical Branch at Galveston
Laurence A. Bindoff
Laurence A. Bindoff Haukeland University Hospital
Thomas Preiss
Thomas Preiss Australian National University
Michael P. Murphy
Michael P. Murphy University of Cambridge
Roderick A. Capaldi
Roderick A. Capaldi University of Oregon

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