World's Best Scientists 2026 revealed!
Maria A. Schumacher

Maria A. Schumacher

D-Index & Metrics

Molecular Biology

D-Index
62
Citations
12289
World Ranking
1857
National Ranking
927

Overview

Maria A. Schumacher is affiliated with Duke University in the United States. Their research spans multiple areas within biochemistry, genetics, and molecular biology, with a significant focus on molecular biology and genetics subfields. They have contributed extensively to topics including bacterial genetics and biotechnology, RNA and protein synthesis mechanisms, bacteriophages and microbial interactions, enzyme structure and function, CRISPR and genetic engineering, DNA and nucleic acid chemistry, and DNA repair mechanisms.

The scientist has published numerous papers in well-known journals. Some recent publications include:

  • High-resolution crystal structures of Escherichia coli FtsZ bound to GDP and GTP, 2020, Acta Crystallographica Section F Structural Biology Communications
  • DNA mismatches reveal conformational penalties in protein-DNA recognition, 2020, Nature
  • When is a transcription factor a NAP?, 2020, Current Opinion in Microbiology
  • The nucleotide messenger (p)ppGpp is an anti-inducer of the purine synthesis transcription regulator PurR in Bacillus, 2021, Nucleic Acids Research
  • Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria, 2022, Nature Communications

Frequent collaborators include:

  • Raul Salinas
  • Richard G. Brennan
  • Brady A. Travis
  • Emily Cannistraci
  • Honglue Shi

The scientist's work regularly appears in several key publication venues, including Nature Communications, Nucleic Acids Research, bioRxiv (Cold Spring Harbor Laboratory), Current Opinion in Microbiology, and the Journal of Molecular Biology.

Their research intersects various scientific disciplines and contributes to understanding the molecular basis of genetic regulation, enzymatic functions, and microbial interactions. This includes detailed structural studies and regulatory mechanisms in bacteria, advancing knowledge relevant to both fundamental biology and potential biotechnological applications.

Best Publications

  • Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.

    Mitchell Lewis;Geoffrey Chang;Nancy C. Horton;Michele A. Kercher

  • Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin.

    Maria A. Schumacher;Andre F. Rivard;Hans Peter Bächinger;Hans Peter Bächinger;John P. Adelman

  • Structures of the pleiotropic translational regulator Hfq and an Hfq–RNA complex: a bacterial Sm‐like protein

    Maria A. Schumacher;Robert F. Pearson;Thorleif Møller;Poul Valentin‐Hansen

  • Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices

    Maria A. Schumacher;Kang Yell Choi;Howard Zalkin;Richard G. Brennan

  • Structural Mechanisms of QacR Induction and Multidrug Recognition

    Maria A. Schumacher;Marshall C. Miller;Steve Grkovic;Melissa H. Brown

  • Molecular Mechanisms of HipA-Mediated Multidrug Tolerance and Its Neutralization by HipB

    Maria A. Schumacher;Kevin M. Piro;Weijun Xu;Sonja Hansen

  • Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR

    Maria A. Schumacher;Marshall C. Miller;Steve Grkovic;Melissa H. Brown

  • The Structure of Irisin Reveals a Novel Intersubunit β-Sheet Fibronectin Type III (FNIII) Dimer IMPLICATIONS FOR RECEPTOR ACTIVATION

    Maria A. Schumacher;Nagababu Chinnam;Tomoo Ohashi;Riddhi Sanjay Shah

  • Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development.

    Natalia Tschowri;Maria A. Schumacher;Susan Schlimpert;Naga babu Chinnam

  • HipBA-promoter structures reveal the basis of heritable multidrug tolerance

    Maria A. Schumacher;Pooja Balani;Jungki Min;Naga Babu Chinnam

  • The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding.

    Maria A. Schumacher;Richard H. Goodman;Richard G. Brennan

  • Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check.

    Nam Ky Tonthat;Stefan T Arold;Brian F Pickering;Michael W Van Dyke

  • Structural Basis for Allosteric Control of the Transcription Regulator CcpA by the Phosphoprotein HPr-Ser46-P

    Maria A. Schumacher;Gregory S. Allen;Marco Diel;Gerald Seidel

  • Crystal Structures of Apocalmodulin and an Apocalmodulin/SK Potassium Channel Gating Domain Complex

    Maria A Schumacher;Matthew Crum;Marshall C Miller

  • Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein

    Maria A Schumacher;Marshall C Miller;Richard G Brennan

  • Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding.

    Maria A Schumacher;Daniel M Scott;Iripam I Mathews;Steven E Ealick

  • Structures of ParB bound to DNA reveal mechanism of partition complex formation

    Maria A. Schumacher;Barbara E. Funnell

  • Characterization of the SarA virulence gene regulator of Staphylococcus aureus.

    Tammy M. Rechtin;Allison F. Gillaspy;Maria A. Schumacher;Richard G. Brennan

  • Structural mechanisms of multidrug recognition and regulation by bacterial multidrug transcription factors.

    Maria A. Schumacher;Richard G. Brennan

  • Crystal Structures of T. brucei MRP1/MRP2 Guide-RNA Binding Complex Reveal RNA Matchmaking Mechanism.

    Maria A. Schumacher;Elham Karamooz;Elham Karamooz;Alena Zíková;Alena Zíková;Lukáš Trantírek

Frequent Co-Authors

Richard G. Brennan
Richard G. Brennan Duke University
Ronald A. Skurray
Ronald A. Skurray University of Sydney
Howard Zalkin
Howard Zalkin Purdue University West Lafayette
Mark J. Buttner
Mark J. Buttner Norwich Research Park
Hans Peter Bächinger
Hans Peter Bächinger Oregon Health & Science University
Melissa H. Brown
Melissa H. Brown Flinders University
Buddy Ullman
Buddy Ullman Oregon Health & Science University
Wolfgang Hillen
Wolfgang Hillen University of Erlangen-Nuremberg
Kim Lewis
Kim Lewis Northeastern University
David S. Roos
David S. Roos University of Pennsylvania

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