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Richard G. Brennan

Richard G. Brennan

D-Index & Metrics

Molecular Biology

D-Index
71
Citations
21243
World Ranking
1364
National Ranking
693

Overview

Richard G. Brennan is affiliated with Duke University in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Within these broad areas, Brennan has worked extensively in subfields including Molecular Biology, Epidemiology, Genetics, Infectious Diseases, and Microbiology.

The scientist's work covers several key topics, such as:

  • Bacterial Genetics and Biotechnology
  • Bacteriophages and microbial interactions
  • Fungal Infections and Studies
  • RNA and protein synthesis mechanisms
  • Vibrio bacteria research studies
  • Reproductive tract infections research
  • Antifungal resistance and susceptibility

Brennan has contributed to numerous research papers, with recent publications including the following:

  • "When is a transcription factor a NAP?" (2020, Current Opinion in Microbiology)
  • "The nucleotide messenger (p)ppGpp is an anti-inducer of the purine synthesis transcription regulator PurR in Bacillus" (2021, Nucleic Acids Research)
  • "Crystal structure of an Escherichia coli Hfq Core (residues 2-69)-DNA complex reveals multifunctional nucleic acid binding sites" (2020, Nucleic Acids Research)
  • "Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria" (2022, Nature Communications)
  • "Structural Basis for Virulence Activation of Francisella tularensis" (2020, Molecular Cell)

The frequent venues for Brennan's publications include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Eastern Mediterranean Health Journal
  • Nucleic Acids Research
  • Current Opinion in Microbiology
  • Nature Communications

Collaborations have been a consistent part of Brennan's work, with frequent co-authors including:

  • Maria A. Schumacher
  • E. Washington
  • Abdinasir Abubakar
  • Mario J. Borgnia
  • Grace A. Beggs

Best Publications

  • Nuclear protein CBP is a coactivator for the transcription factor CREB

    Roland P. S. Kwok;James R. Lundblad;John C. Chrivia;Jane P. Richards

  • The TetR Family of Transcriptional Repressors

    Juan L. Ramos;Manuel Martínez-Bueno;Antonio J. Molina-Henares;Wilson Terán

  • Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.

    Mitchell Lewis;Geoffrey Chang;Nancy C. Horton;Michele A. Kercher

  • The helix-turn-helix DNA binding motif.

    R G Brennan;B W Matthews

  • Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction.

    Thorleif Møller;Thomas Franch;Peter Højrup;Douglas R Keene

  • Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif.

    Daniel W. Carr;Renata E. Stofko-Hahn;Iain D C Fraser;Sarah M. Bishop

  • Structures of the pleiotropic translational regulator Hfq and an Hfq–RNA complex: a bacterial Sm‐like protein

    Maria A. Schumacher;Robert F. Pearson;Thorleif Møller;Poul Valentin‐Hansen

  • Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices

    Maria A. Schumacher;Kang Yell Choi;Howard Zalkin;Richard G. Brennan

  • Hfq structure, function and ligand binding.

    Richard G Brennan;Todd M Link

  • Structural Mechanisms of QacR Induction and Multidrug Recognition

    Maria A. Schumacher;Marshall C. Miller;Steve Grkovic;Melissa H. Brown

  • Structure of Escherichia coli Hfq bound to polyriboadenylate RNA

    Todd M. Link;Poul Valentin-Hansen;Richard G. Brennan

  • Molecular Mechanisms of HipA-Mediated Multidrug Tolerance and Its Neutralization by HipB

    Maria A. Schumacher;Kevin M. Piro;Weijun Xu;Sonja Hansen

  • Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains.

    Keith P. Wilson;Lisa M. Shewchuk;Richard G. Brennan;Anthony J. Otsuka

  • Crystal structure of the transcription activator BmrR bound to DNA and a drug.

    Ekaterina E. Zheleznova Heldwein;Richard G. Brennan

  • Structure of an OhrR-ohrA Operator Complex Reveals the DNA Binding Mechanism of the MarR Family

    Minsun Hong;Mayuree Fuangthong;John D. Helmann;Richard G. Brennan

  • The winged-helix DNA-binding motif: Another helix-turn-helix takeoff

    Richard G. Brennan

  • Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR

    Maria A. Schumacher;Marshall C. Miller;Steve Grkovic;Melissa H. Brown

  • Glutathione activates virulence gene expression of an intracellular pathogen

    Michelle L. Reniere;Aaron T. Whiteley;Keri L. Hamilton;Sonya M. John

  • Prokaryotic transcription regulators: more than just the helix-turn-helix motif.

    Joy L Huffman;Richard G Brennan

  • Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter.

    Ekaterina E. Zheleznova;Penelope N. Markham;Alexander A. Neyfakh;Richard G. Brennan

Frequent Co-Authors

Maria A. Schumacher
Maria A. Schumacher Duke University
Howard Zalkin
Howard Zalkin Purdue University West Lafayette
Wolfgang Hillen
Wolfgang Hillen University of Erlangen-Nuremberg
Buddy Ullman
Buddy Ullman Oregon Health & Science University
Melissa H. Brown
Melissa H. Brown Flinders University
Richard H. Goodman
Richard H. Goodman Oregon Health & Science University
James M. Musser
James M. Musser Houston Methodist
Mark J. Buttner
Mark J. Buttner Norwich Research Park
Ronald A. Skurray
Ronald A. Skurray University of Sydney
John D. Helmann
John D. Helmann Cornell University

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