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William M. Shafer

William M. Shafer

D-Index & Metrics

Microbiology

D-Index
69
Citations
14628
World Ranking
2085
National Ranking
876

Research.com Recognitions

  • 1954 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

William M. Shafer is affiliated with Emory University in the United States and has contributed extensively to research in the fields of immunology, microbiology, and medicine. Their work spans various subfields including microbiology, physiology, infectious diseases, epidemiology, and molecular medicine.

Their main research topics focus on reproductive tract infections, bacterial infections and vaccines, syphilis diagnosis and treatment, as well as antibiotic resistance and infections caused by Clostridium difficile and Clostridium perfringens. Further areas of study include amoebic infections and treatments, and respiratory infections such as pneumonia.

William M. Shafer has published notable papers including:

  • A community-driven resource for genomic epidemiology and antimicrobial resistance prediction of Neisseria gonorrhoeae at Pathogenwatch (2021) in Genome Medicine
  • The serogroup B meningococcal outer membrane vesicle-based vaccine 4CMenB induces cross-species protection against Neisseria gonorrhoeae (2020) in PLoS Pathogens
  • Genomic evolution of Neisseria gonorrhoeae since the preantibiotic era (1928-2013): antimicrobial use/misuse selects for resistance and drives evolution (2020) in BMC Genomics
  • Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance (2020) in mBio
  • Azithromycin susceptibility of Neisseria gonorrhoeae in the USA in 2017: a genomic analysis of surveillance data (2020) in The Lancet Microbe

Frequent coauthors collaborating with William M. Shafer include:

  • Jacqueline T. Balthazar
  • Ann E. Jerse
  • Magnus Unemo
  • Julio C. Ayala
  • Concerta L. Holley

They have published regularly in venues such as mBio, bioRxiv (Cold Spring Harbor Laboratory), UNC Libraries, PLoS Pathogens, and Microbiology Spectrum. These journals reflect a focus on microbiological and infectious disease research.

William M. Shafer was named a Fellow of the American Association for the Advancement of Science (AAAS) in 1954.

Best Publications

  • Antimicrobial Resistance in Neisseria gonorrhoeae in the 21st Century: Past, Evolution, and Future

    Magnus Unemo;William M. Shafer;William M. Shafer

  • Degradation of Human Antimicrobial Peptide LL-37 by Staphylococcus aureus-Derived Proteinases

    Magdalena Sieprawska-Lupa;Piotr Mydel;Katarzyna Krawczyk;Kinga Wójcik

  • Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family

    W. M. Shafer;X.-D. Qu;A. J. Waring;R. I. Lehrer

  • Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system

    Kayla E. Hagman;Wubin Pan;Brian G. Spratt;Jacqueline T. Balthazar

  • Cationic Antimicrobial Peptide Resistance in Neisseria meningitidis

    Yih-Ling Tzeng;Karita D. Ambrose;Susu Zughaier;Xiaoliu Zhou

  • Antibiotic resistance in Neisseria gonorrhoeae: origin, evolution, and lessons learned for the future

    Magnus Unemo;William M. Shafer

  • Cationic antimicrobial proteins isolated from human neutrophil granulocytes in the presence of diisopropyl fluorophosphate.

    W M Shafer;L E Martin;J K Spitznagel

  • Clinically Relevant Mutations that Cause Derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE Efflux Pump System Confer Different Levels of Antimicrobial Resistance and In Vivo Fitness

    Douglas M. Warner;William M. Shafer;William M. Shafer;Ann E. Jerse

  • Antimicrobial Resistance Expressed by Neisseria gonorrhoeae: A Major Global Public Health Problem in the 21st Century

    Magnus Unemo;Carlos del Rio;William M. Shafer;William M. Shafer

  • A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection.

    Ann E. Jerse;Nirmala D. Sharma;Amy N. Simms;Emily T. Crow

  • Transcriptional control of the mtr efflux system of Neisseria gonorrhoeae.

    K E Hagman;W M Shafer

  • Overexpression of the MtrC-MtrD-MtrE Efflux Pump Due to an mtrR Mutation Is Required for Chromosomally Mediated Penicillin Resistance in Neisseria gonorrhoeae

    Wendy L. Veal;Wendy L. Veal;Robert A. Nicholas;William M. Shafer;William M. Shafer

  • Neisseria gonorrhoeae: Drug Resistance, Mouse Models, and Vaccine Development.

    Peter A Rice;William M Shafer;Sanjay Ram;Ann E Jerse

  • Decreased azithromycin susceptibility of Neisseria gonorrhoeae due to mtrR mutations.

    Leticia Zarantonelli;Graciela Borthagaray;Eun-Hee Lee;Eun-Hee Lee;William M. Shafer;William M. Shafer

  • The farAB-encoded efflux pump mediates resistance of gonococci to long-chained antibacterial fatty acids

    Eun Hee Lee;William M. Shafer;William M. Shafer

  • CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity

    H A Pereira;W M Shafer;J Pohl;L E Martin

  • The NorM Efflux Pump of Neisseria gonorrhoeae and Neisseria meningitidis Recognizes Antimicrobial Cationic Compounds

    Corinne E Rouquette-Loughlin;Steven A Dunham;Michael Kuhn;Jacqueline T Balthazar

  • Multidrug-resistant gonorrhea: A research and development roadmap to discover new medicines.

    Emilie Alirol;Teodora E. Wi;Manju Bala;Maria Luiza Bazzo

  • The MtrD protein of Neisseria gonorrhoeae is a member of the resistance/nodulation/division protein family constituting part of an efflux system

    Kayla E. Hagman;Claressa E. Lucas;Jacqueline T. Balthazar;Lori Snyder

  • Experimental Gonococcal Infection in Male Volunteers: Cumulative Experience with Neisseria gonorrhoeae Strains FA1090 and MS11mkC

    Marcia Metzgar Hobbs;Philip Frederick Sparling;Myron S. Cohen;William M. Shafer;William M. Shafer

  • Genetics of staphylococcal enterotoxin B in methicillin-resistant isolates of Staphylococcus aureus.

    W M Shafer;J J Iandolo

Frequent Co-Authors

Ann E. Jerse
Ann E. Jerse Uniformed Services University of the Health Sciences
Magnus Unemo
Magnus Unemo Örebro University
David S. Stephens
David S. Stephens Emory University
Jan Pohl
Jan Pohl Centers for Disease Control and Prevention
Daniel Golparian
Daniel Golparian Örebro University
Timothy D. Read
Timothy D. Read Emory University
Russell W. Carlson
Russell W. Carlson University of Georgia
Yonatan H. Grad
Yonatan H. Grad Harvard University
Peter A. Rice
Peter A. Rice University of Massachusetts Chan Medical School
Simon R. Harris
Simon R. Harris Wellcome Sanger Institute

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