World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
63
Citations
12158
World Ranking
2787
National Ranking
1111

Genetics

D-Index
62
Citations
11414
World Ranking
2999
National Ranking
1308

Research.com Recognitions

  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

H. Steven Seifert is affiliated with Northwestern University in the United States. Their research primarily focuses on immunology and microbiology, specifically in the fields of microbiology, molecular biology, infectious diseases, ecology, and immunology. The scientist's work spans topics such as bacterial infections and vaccines, reproductive tract infections research, bacteriophages and microbial interactions, SARS-CoV-2 and COVID-19 research, amoebic infections and treatments, machine learning in bioinformatics, and DNA and nucleic acid chemistry.

Notable recent publications include:

  • Discovery of a New Neisseria gonorrhoeae Type IV Pilus Assembly Factor, TfpC (2020), published in mBio
  • Altering the Neisseria gonorrhoeae pilE Guanine Quadruplex Loop Bases Affects Pilin Antigenic Variation (2020), published in Biochemistry
  • The Neisseria gonorrhoeae type IV pilus promotes resistance to hydrogen peroxide- and LL-37-mediated killing by modulating the availability of intracellular, labile iron (2022), published in PLoS Pathogens
  • Challenges and Controversies Concerning Neisseria gonorrhoeae-Neutrophil Interactions in Pathogenesis (2021), published in mBio
  • Development and implementation of a Type I-C CRISPR-based programmable repression system for Neisseria gonorrhoeae (2023), published in mBio

Seifert has frequently published in venues such as mBio, UNC Libraries, PLoS Pathogens, bioRxiv (Cold Spring Harbor Laboratory), and Biochemistry.

Frequent co-authors in their publications include Shaohui Yin, Linda I. Hu, Egon A. Ozer, Lee Sewell, and Saima Rehman. These collaborations indicate a network working on bacterial pathogenesis and molecular microbiology topics.

The scientist's research contributes to understanding bacterial mechanisms, particularly involving Neisseria gonorrhoeae, a significant human pathogen responsible for gonorrhea. Their work involves studying bacterial pilus assembly, antigenic variation, resistance mechanisms against host defenses, and innovative gene regulation techniques using CRISPR systems.

H. Steven Seifert was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2007, highlighting their involvement in the broader scientific community.

Best Publications

  • Gonorrhoea

    Unknown

  • Single pilus motor forces exceed 100 pN

    Berenike Maier;Laura Potter;Magdalene So;Hank S. Seifert

  • Neisseria gonorrhoeae host-adaptation and pathogenesis

    Sarah Jane Quillin;H Steven Seifert

  • Shuttle mutagenesis: a method of transposon mutagenesis for Saccharomyces cerevisiae

    H. S. Seifert;E. Y. Chen;M. So;F. Heffron

  • An alternative DNA structure is necessary for pilin antigenic variation in Neisseria gonorrhoeae

    Laty A. Cahoon;H. Steven Seifert

  • Processing-Independent CRISPR RNAs Limit Natural Transformation in Neisseria meningitidis

    Yan Zhang;Nadja Heidrich;Biju Joseph Ampattu;Carl W. Gunderson

  • A variable genetic island specific for Neisseria gonorrhoeae is involved in providing DNA for natural transformation and is found more often in disseminated infection isolates

    Joseph P. Dillard;H. Steven Seifert

  • Species-specific uptake of DNA by gonococci is mediated by a 10-base-pair sequence

    C Elkins;C E Thomas;H S Seifert;P F Sparling

  • Multiple gonococcal opacity proteins are expressed during experimental urethral infection in the male.

    A E Jerse;M S Cohen;P M Drown;L G Whicker

  • Differential roles of homologous recombination pathways in Neisseria gonorrhoeae pilin antigenic variation, DNA transformation and DNA repair.

    Ian J. Mehr;H. Steven Seifert

  • Escherichia coli RecX Inhibits RecA Recombinase and Coprotease Activities in Vitro and in Vivo

    Elizabeth A. Stohl;Joel P. Brockman;Kristin L. Burkle;Katsumi Morimatsu

  • DNA transformation leads to pilin antigenic variation in Neisseria gonorrhoeae.

    H. Steven Seifert;H. Steven Seifert;Richard S. Ajioka;Christian Marchal;Christian Marchal;P. Frederick Sparling

  • Multiple gonococcal pilin antigenic variants are produced during experimental human infections.

    H S Seifert;C J Wright;C J Wright;A E Jerse;M S Cohen

  • Characterization of the pilF-pilD pilus-assembly locus of Neisseria gonorrhoeae

    Nancy E. Freitag;H. Steven Seifert;Michael Koomey

  • Antigenic variation of gonococcal pilus involves assembly of separated silent gene segments.

    E. Segal;P. Hagblom;H. S. Seifert;M. So

  • A bacterial siren song: intimate interactions between Neisseria and neutrophils

    Alison K. Criss;H. Steven Seifert

  • Genetic mechanisms of bacterial antigenic variation.

    H S Seifert;M So

  • Questions about gonococcal pilus phase- and antigenic variation

    H. Steven Seifert

  • The frequency and rate of pilin antigenic variation in Neisseria gonorrhoeae

    Alison K. Criss;Kimberly A. Kline;H. Steven Seifert

  • A Homologue of the Recombination-Dependent Growth Gene, rdgC, Is Involved in Gonococcal Pilin Antigenic Variation

    Ian J. Mehr;Cynthia D. Long;Carla D. Serkin;H. Steven Seifert

  • The outer membrane localization of the Neisseria gonorrhoeae MsrA/B is involved in survival against reactive oxygen species

    Eric P. Skaar;Deborah M. Tobiason;J. Quick;Ralph C. Judd

Frequent Co-Authors

Eric P. Skaar
Eric P. Skaar Vanderbilt University Medical Center
Michael M. Cox
Michael M. Cox University of Wisconsin–Madison
William M. Shafer
William M. Shafer Emory University
Magdalene So
Magdalene So University of Arizona
Michael A. Apicella
Michael A. Apicella University of Iowa
P. Frederick Sparling
P. Frederick Sparling University of North Carolina at Chapel Hill
Erik J. Sontheimer
Erik J. Sontheimer University of Massachusetts Chan Medical School
John K. Davies
John K. Davies Monash University
Stephen C. Kowalczykowski
Stephen C. Kowalczykowski University of California, Davis
Jörg Vogel
Jörg Vogel University of Würzburg

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