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Biology and Biochemistry

D-Index
61
Citations
24950
World Ranking
11101
National Ranking
4802

Overview

Erik J. Sontheimer is a researcher affiliated with the University of Massachusetts Chan Medical School in the United States. Their work spans several main fields, including Biochemistry, Genetics, and Molecular Biology, with contributions also in Medicine. Within these broader areas, their research focuses notably on Molecular Biology and Genetics, alongside additional interests in Epidemiology, Public Health, Environmental and Occupational Health, and Plant Science.

Their scientific contributions primarily address topics related to genetic engineering and molecular techniques. Key research themes include:

  • CRISPR and Genetic Engineering
  • Advanced biosensing and bioanalysis techniques
  • RNA Interference and Gene Delivery
  • Virus-based gene therapy research
  • RNA regulation and disease
  • RNA and protein synthesis mechanisms
  • Cytomegalovirus and herpesvirus research

Sontheimer's publication record features several recent papers in prominent journals. Notable titles include:

  • Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice (2021, Nature Communications)
  • Anti-CRISPRs: Protein Inhibitors of CRISPR-Cas Systems (2020, Annual Review of Biochemistry)
  • A split prime editor with untethered reverse transcriptase and circular RNA template (2022, Nature Biotechnology)
  • An engineered ScCas9 with broad PAM range and high specificity and activity (2020, Nature Biotechnology)
  • The NIH Somatic Cell Genome Editing program (2021, Nature)

Their research has been published extensively in several key venues, including the following frequent publication locations:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nature Biotechnology
  • GEN Biotechnology
  • Nucleic Acids Research

Collaboration forms an important aspect of Sontheimer's work. Frequent co-authors include:

  • Wen Xue
  • Tomás Rodríguez
  • Scot A. Wolfe
  • Jonathan K. Watts
  • Guangping Gao

Best Publications

  • Origins and Mechanisms of miRNAs and siRNAs

    Richard W. Carthew;Erik J. Sontheimer

  • CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA

    Luciano A. Marraffini;Erik J. Sontheimer

  • Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways.

    Young Sik Lee;Kenji Nakahara;John W Pham;Kevin Kim

  • CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea

    Luciano A. Marraffini;Erik J. Sontheimer

  • Self versus non-self discrimination during CRISPR RNA-directed immunity

    Luciano A. Marraffini;Erik J. Sontheimer

  • Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis

    Zhonggang Hou;Yan Zhang;Nicholas E. Propson;Sara E. Howden

  • Assembly and function of RNA silencing complexes.

    Erik J. Sontheimer

  • A Dicer-2-Dependent 80S Complex Cleaves Targeted mRNAs during RNAi in Drosophila

    John W Pham;Janice L Pellino;Young Sik Lee;Richard W Carthew

  • The U5 and U6 small nuclear RNAs as active site components of the spliceosome

    Erik J. Sontheimer;Joan A. Steitz

  • Naturally Occurring Off-Switches for CRISPR-Cas9

    April Pawluk;Nadia Amrani;Yan Zhang;Bianca Garcia

  • Site-specific cross-linking of mammalian U5 snRNP to the 5' splice site before the first step of pre-mRNA splicing.

    J R Wyatt;E J Sontheimer;J A Steitz

  • Silencing by small RNAs is linked to endosomal trafficking

    Young Sik Lee;Sigal Pressman;Arlise P. Andress;Kevin Kim

  • TARGET DNA INTERFERENCE WITH crRNA

    Erik J. Sontheimer;Luciano A. Marraffini

  • Silence from within: Endogenous siRNAs and miRNAs

    Erik J. Sontheimer;Richard W. Carthew

  • Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses.

    Dan Wang;Haiwei Mou;Shaoyong Li;Yingxiang Li

  • Processing-Independent CRISPR RNAs Limit Natural Transformation in Neisseria meningitidis

    Yan Zhang;Nadja Heidrich;Biju Joseph Ampattu;Carl W. Gunderson

  • A Broad-Spectrum Inhibitor of CRISPR-Cas9.

    Lucas B. Harrington;Kevin W. Doxzen;Enbo Ma;Jun Jie Liu

  • Metal ion catalysis during splicing of premessenger RNA

    Erik J. Sontheimer;Sengen Sun;Joseph A. Piccirilli

  • A compact, high-accuracy Cas9 with a dinucleotide PAM for in vivo genome editing

    Alireza Edraki;Aamir Mir;Raed Ibraheim;Ildar Gainetdinov

  • Erratum: Silencing by small RNAs is linked to endosomal trafficking (Nature Cell Biology (2009) 11 (1150-1156))

    Young Sik Lee;Sigal Pressman;Arlise P. Andress;Kevin Kim

Frequent Co-Authors

Scot A. Wolfe
Scot A. Wolfe University of Massachusetts Chan Medical School
Wen Xue
Wen Xue University of Massachusetts Chan Medical School
Alan R. Davidson
Alan R. Davidson University of Toronto
Lihua Julie Zhu
Lihua Julie Zhu University of Massachusetts Chan Medical School
Richard W. Carthew
Richard W. Carthew Northwestern University
Luciano A. Marraffini
Luciano A. Marraffini Rockefeller University
Jennifer A. Doudna
Jennifer A. Doudna University of California, Berkeley
Guangping Gao
Guangping Gao University of Massachusetts Chan Medical School
Joseph A. Piccirilli
Joseph A. Piccirilli University of Chicago
Zhiping Weng
Zhiping Weng University of Massachusetts Chan Medical School

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