2014 - Fellow, National Academy of Inventors
Genetics, RNA silencing, RNA, RNA interference and Cell biology are his primary areas of study. His research combines Computational biology and Genetics. His research integrates issues of Small RNA, Dicer and Trans-acting siRNA in his study of RNA silencing.
RNA is represented through his RNA-induced transcriptional silencing, RNA-induced silencing complex and DNA-directed RNA interference research. His RNA interference research incorporates elements of Molecular biology, Gene silencing and Enzyme complex. The various areas that Phillip D. Zamore examines in his Cell biology study include Non-coding RNA, Ribonucleoprotein, Splicing Factor U2AF, snRNP and Small interfering RNA.
His primary scientific interests are in Genetics, RNA, Cell biology, RNA interference and Gene silencing. His work deals with themes such as Cleavage and Oligonucleotide, which intersect with RNA. His biological study spans a wide range of topics, including Molecular biology, microRNA, Gene expression and Messenger RNA.
Phillip D. Zamore does research in RNA interference, focusing on RNA silencing specifically. His RNA silencing study integrates concerns from other disciplines, such as DNA-directed RNA interference, Non-coding RNA, RNA-induced transcriptional silencing and Dicer. Phillip D. Zamore works mostly in the field of Argonaute, limiting it down to concerns involving Small RNA and, occasionally, Transposable element.
His primary areas of study are Cell biology, RNA, Piwi-interacting RNA, microRNA and RNA interference. Phillip D. Zamore has researched Cell biology in several fields, including Genome editing, Transfection, Argonaute and Recombinant DNA. His RNA research is multidisciplinary, incorporating perspectives in Polyacrylamide gel electrophoresis and Molecular biology.
His Piwi-interacting RNA research is multidisciplinary, relying on both Transcription, Gene expression and Germline. His work carried out in the field of RNA interference brings together such families of science as Gene silencing and Small interfering RNA. His Gene research is classified as research in Genetics.
Phillip D. Zamore mainly focuses on RNA, Piwi-interacting RNA, Cell biology, RNA interference and Transposable element. His work focuses on many connections between RNA and other disciplines, such as Computational biology, that overlap with his field of interest in Polymerase chain reaction. The Cell biology study combines topics in areas such as Gene expression, Expression vector, Argonaute, Capsid and Genome editing.
The concepts of his RNA interference study are interwoven with issues in Gene silencing and microRNA. His Gene silencing research is multidisciplinary, incorporating elements of Aptamer and Small interfering RNA. Gene is a subfield of Genetics that Phillip D. Zamore tackles.
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RNAi: Double-Stranded RNA Directs the ATP-Dependent Cleavage of mRNA at 21 to 23 Nucleotide Intervals
Phillip D. Zamore;Thomas Tuschl;Phillip A. Sharp;David P. Bartel.
Asymmetry in the assembly of the RNAi enzyme complex.
Dianne S. Schwarz;György Hutvágner;Tingting Du;Zuoshang Xu.
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA.
György Hutvágner;Juanita McLachlan;Amy E. Pasquinelli;Éva Bálint.
A microRNA in a multiple-turnover RNAi enzyme complex.
György Hutvágner;Phillip D. Zamore.
Small silencing RNAs: an expanding universe
Megha Ghildiyal;Phillip D. Zamore.
Nature Reviews Genetics (2009)
ATP requirements and small interfering RNA structure in the RNA interference pathway.
Antti Nykänen;Benjamin Haley;Phillip D. Zamore.
Targeted mRNA degradation by double-stranded RNA in vitro
Thomas Tuschl;Phillip D. Zamore;Ruth Lehmann;David P. Bartel.
Genes & Development (1999)
Ribo-gnome: the big world of small RNAs
Phillip D. Zamore;Benjamin Haley.
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
Christian B. Matranga;Yukihide Tomari;Chanseok Shin;David P. Bartel.
A Distinct Small RNA Pathway Silences Selfish Genetic Elements in the Germline
Vasily V. Vagin;Alla A. Sigova;Chengjian Li;Herve Seitz.
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