World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
91
Citations
104957
World Ranking
1016
National Ranking
495

Research.com Recognitions

  • 2011 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

W. Richard McCombie is affiliated with Cold Spring Harbor Laboratory in the United States. Their research primarily falls within the field of Biochemistry, Genetics and Molecular Biology, with a notable focus on Molecular Biology, Genetics, and Plant Science. They have also contributed work in the areas of Cancer Research and Oncology.

The scientist's research topics cover a range of areas including:

  • Genomics and Phylogenetic Studies
  • Chromosomal and Genetic Variations
  • CRISPR and Genetic Engineering
  • Genomics and Rare Diseases
  • Cancer Genomics and Diagnostics
  • DNA Repair Mechanisms
  • Molecular Biology Techniques and Applications

Among recent publications, McCombie has contributed to studies such as:

  • Major Impacts of Widespread Structural Variation on Gene Expression and Crop Improvement in Tomato, 2020, Cell
  • Comprehensive analysis of structural variants in breast cancer genomes using single-molecule sequencing, 2020, Genome Research
  • Familial long-read sequencing increases yield of de novo mutations, 2022, The American Journal of Human Genetics
  • High-coverage nanopore sequencing of samples from the 1000 Genomes Project to build a comprehensive catalog of human genetic variation, 2024, Genome Research
  • Long-Read Sequencing Reveals Rapid Evolution of Immunity- and Cancer-Related Genes in Bats, 2023, Genome Biology and Evolution

Frequent co-authors in McCombie's body of work include:

  • Melissa Kramer
  • Sara Goodwin
  • Michael C. Schatz
  • Shruti V. Iyer
  • Doreen Ware

The scientist regularly publishes in several key venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Genome Research
  • Molecular Psychiatry
  • Nature Communications
  • Cancer Research

McCombie is a recipient of the Fellow of the American Association for the Advancement of Science (AAAS) award, received in 2011.

Best Publications

  • Initial sequencing and analysis of the human genome.

    Eric S. Lander;Lauren M. Linton;Bruce Birren;Chad Nusbaum

  • Initial sequencing and comparative analysis of the mouse genome.

    Robert H. Waterston;Kerstin Lindblad-Toh;Ewan Birney;Jane Rogers

  • The map-based sequence of the rice genome

    Takashi Matsumoto;Jianzhong Wu;Hiroyuki Kanamori;Yuichi Katayose

  • The B73 Maize Genome: Complexity, Diversity, and Dynamics

    Patrick S. Schnable;Doreen Ware;Robert S. Fulton;Joshua C. Stein

  • Coming of age: ten years of next-generation sequencing technologies

    Sara Goodwin;John Douglas Mcpherson;W. Richard McCombie

  • Complementary DNA sequencing : expressed sequence tags and human genome project

    Mark D. Adams;Jenny M. Kelley;Jeannine D. Gocayne;Mark Dubnick

  • The tomato genome sequence provides insights into fleshy fruit evolution

    Shusei Sato;Satoshi Tabata;Hideki Hirakawa;Erika Asamizu

  • Tumour evolution inferred by single-cell sequencing

    Nicholas E Navin;Jude Kendall;Jennifer Troge;Peter M Andrews

  • The contribution of de novo coding mutations to autism spectrum disorder

    Ivan Iossifov;Brian J. O'Roak;Stephan J. Sanders;Stephan J. Sanders;Michael Ronemus

  • Improvement of the Oryza sativa Nipponbare reference genome using next generation sequence and optical map data

    Yoshihiro Kawahara;Melissa de la Bastide;John P Hamilton;Hiroyuki Kanamori

  • The genome sequence of Schizosaccharomyces pombe

    V. Wood;R. Gwilliam;M.A. Rajandream;M. Lyne

  • De Novo Gene Disruptions in Children on the Autistic Spectrum

    Ivan Iossifov;Michael Ronemus;Dan Levy;Zihua Wang

  • Role of transposable elements in heterochromatin and epigenetic control

    Zachary Lippman;Anne Valérie Gendrel;Michael Black;Michael Black;Matthew W. Vaughn

  • Analysis of the bread wheat genome using whole-genome shotgun sequencing

    Rachel Brenchley;Manuel Spannagl;Matthias Pfeifer;Gary L. A. Barker

  • Improved maize reference genome with single-molecule technologies

    Yinping Jiao;Paul Peluso;Jinghua Shi;Tiffany Y. Liang

  • Hybrid error correction and de novo assembly of single-molecule sequencing reads

    Sergey Koren;Michael C Schatz;Brian P Walenz;Jeffrey Martin

  • Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana

    K. Mayer;C. Schüller;R. Wambutt;G. Murphy

  • Draft genome sequence of pigeonpea (Cajanus cajan), an orphan legume crop of resource-poor farmers

    Rajeev K Varshney;Rajeev K Varshney;Wenbin Chen;Yupeng Li;Arvind K Bharti

  • Specialized piRNA Pathways Act in Germline and Somatic Tissues of the Drosophila Ovary

    Colin D. Malone;Colin D. Malone;Julius Brennecke;Julius Brennecke;Monica Dus;Monica Dus;Alexander Stark

  • A resource for large-scale RNA-interference-based screens in mammals

    Patrick J. Paddison;Jose M. Silva;Douglas S. Conklin;Douglas S. Conklin;Mike Schlabach;Mike Schlabach

Frequent Co-Authors

Michael C. Schatz
Michael C. Schatz Johns Hopkins University
Gregory J. Hannon
Gregory J. Hannon University of Cambridge
Robert A. Martienssen
Robert A. Martienssen Cold Spring Harbor Laboratory
Elaine R. Mardis
Elaine R. Mardis The Ohio State University
Doreen Ware
Doreen Ware Cold Spring Harbor Laboratory
Rod A. Wing
Rod A. Wing University of Arizona
Andrew M. McIntosh
Andrew M. McIntosh University of Edinburgh
John Douglas Mcpherson
John Douglas Mcpherson University of California, Davis
Richard K. Wilson
Richard K. Wilson Nationwide Children's Hospital
Yeisoo Yu
Yeisoo Yu University of Arizona

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