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Haruhiko Siomi

Haruhiko Siomi

D-Index & Metrics

Genetics

D-Index
66
Citations
23046
World Ranking
2582
National Ranking
100

Overview

Haruhiko Siomi is affiliated with Keio University in Japan and has contributed extensively to the fields of biochemistry, genetics, and molecular biology. Their research spans multiple areas including molecular biology, plant science, infectious diseases, genetics, and immunology. The scientist's work covers topics such as chromosomal and genetic variations, CRISPR and genetic engineering, SARS-CoV-2 and COVID-19 research, genomics and chromatin dynamics, COVID-19 clinical research studies, SARS-CoV-2 detection and testing, and RNA research and splicing.

Siomi has published in several notable scientific venues. Frequent publication outlets include bioRxiv (Cold Spring Harbor Laboratory) with 11 publications, Nucleic Acids Research and Science Advances with 2 publications each, and Nature Genetics and Nature Communications with 1 publication each.

Recent papers authored or co-authored by Siomi highlight diverse molecular biology topics. These papers include:

  • Transcription of MERVL retrotransposons is required for preimplantation embryo development (2023, Nature Genetics)
  • Crystal structure of Drosophila Piwi (2020, Nature Communications)
  • Production of functional oocytes requires maternally expressed PIWI genes and piRNAs in golden hamsters (2021, Nature Cell Biology)
  • Hamster PIWI proteins bind to piRNAs with stage-specific size variations during oocyte maturation (2021, Nucleic Acids Research)
  • Piwi suppresses transcription of Brahma-dependent transposons via Maelstrom in ovarian somatic cells (2020, Science Advances)

Throughout their career, Siomi has collaborated frequently with several co-authors. The most frequent collaborators include Kensaku Murano and Yuka W. Iwasaki with 14 joint publications each, Hirotsugu Ishizu with 12, Youjia Guo with 11, and Tomohiro Kitano with 8 publications.

Best Publications

  • A slicer-mediated mechanism for repeat-associated siRNA 5' end formation in Drosophila.

    Lalith S. Gunawardane;Kuniaki Saito;Kazumichi M. Nishida;Keita Miyoshi

  • Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways

    Katsutomo Okamura;Akira Ishizuka;Haruhiko Siomi;Mikiko C. Siomi

  • On the road to reading the RNA-interference code.

    Haruhiko Siomi;Mikiko C. Siomi

  • The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein.

    Haruhiko Siomi;Mikiko C. Siomi;Robert L. Nussbaum;Gideon Dreyfuss

  • A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins

    Akira Ishizuka;Mikiko C. Siomi;Haruhiko Siomi

  • Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome

    Kuniaki Saito;Kazumichi M. Nishida;Tomoko Mori;Yoshinori Kawamura

  • Posttranscriptional regulation of microRNA biogenesis in animals.

    Haruhiko Siomi;Mikiko C. Siomi

  • The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans

    Hiroaki Tabara;Erbay Yigit;Haruhiko Siomi;Craig C. Mello

  • The pre-mRNA binding K protein contains a novel evolutionary conserved motif

    Haruhiko Siomi;Michael J. Matunis;W. Matthew Michael;Gideon Dreyfuss

  • A nuclear localization domain in the hnRNP A1 protein

    Haruhiko Siomi;Gideon Dreyfuss

  • PIWI-Interacting RNA: Its Biogenesis and Functions

    Yuka W. Iwasaki;Mikiko C. Siomi;Haruhiko Siomi

  • Essential role for KH domains in RNA binding: impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome.

    Haruhiko Siomi;Mleyoung Choi;Mikiko C. Siomi;Robert L. Nussbaum

  • Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells

    Yoshinori Kawamura;Kuniaki Saito;Kuniaki Saito;Taishin Kin;Yukiteru Ono

  • Processing of Pre-microRNAs by the Dicer-1–Loquacious Complex in Drosophila Cells

    Kuniaki Saito;Akira Ishizuka;Haruhiko Siomi;Mikiko C Siomi

  • Pimet, the Drosophila homolog of HEN1, mediates 2′-O-methylation of Piwi- interacting RNAs at their 3′ ends

    Kuniaki Saito;Yuriko Sakaguchi;Takeo Suzuki;Tsutomu Suzuki

  • Slicer function of Drosophila Argonautes and its involvement in RISC formation

    Keita Miyoshi;Hiroko Tsukumo;Tomoko Nagami;Haruhiko Siomi

  • A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila

    Kuniaki Saito;Sachi Inagaki;Toutai Mituyama;Yoshinori Kawamura;Yoshinori Kawamura

  • Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlines

    Hirotsugu Ishizu;Haruhiko Siomi;Mikiko C. Siomi;Mikiko C. Siomi

  • Structure and function of Zucchini endoribonuclease in piRNA biogenesis

    Hiroshi Nishimasu;Hirotsugu Ishizu;Hirotsugu Ishizu;Kuniaki Saito;Satoshi Fukuhara

  • Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila

    Kuniaki Saito;Hirotsugu Ishizu;Miharu Komai;Hazuki Kotani

Frequent Co-Authors

Mikiko C. Siomi
Mikiko C. Siomi University of Tokyo
Masakazu Hatanaka
Masakazu Hatanaka Kyoto University
Gideon Dreyfuss
Gideon Dreyfuss University of Pennsylvania
Masatoshi Maki
Masatoshi Maki Nagoya University
Hiroshi Nishimasu
Hiroshi Nishimasu University of Tokyo
Satoshi Kubota
Satoshi Kubota Okayama University
Hisataka Sabe
Hisataka Sabe Hokkaido University
Osamu Nureki
Osamu Nureki University of Tokyo
Norio Ishida
Norio Ishida National Institute of Advanced Industrial Science and Technology

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