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Hisataka Sabe

Hisataka Sabe

D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
11976
World Ranking
10939
National Ranking
748

Overview

Hisataka Sabe is affiliated with Hokkaido University in Japan and has contributed extensively to the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research spans a variety of subfields including Molecular Biology, Oncology, Physiology, Immunology, and Cardiology and Cardiovascular Medicine.

The scientist's work prominently focuses on topics such as RNA modifications and cancer, adipose tissue and metabolism, mitochondrial function and pathology, cancer immunotherapy and biomarkers, pancreatic and hepatic oncology research, phagocytosis and immune regulation, and immune cell function and interaction. These topics reflect a broad engagement with molecular mechanisms underlying disease and immune responses.

Hisataka Sabe has published research in several scientific venues. The most frequent publication outlets include Cell Communication and Signaling, Scientific Reports, bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, and Cancer Immunology Research.

Some of their recent notable papers include:

  • "Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure," 2022, Proceedings of the National Academy of Sciences
  • "Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression," 2021, Cancer Immunology Research
  • "Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance," 2020, Cardiovascular Research
  • "Abnormalities of Skeletal Muscle, Adipocyte Tissue, and Lipid Metabolism in Heart Failure: Practical Therapeutic Targets," 2020, Frontiers in Cardiovascular Medicine
  • "Brain-Derived Neurotrophic Factor Improves Impaired Fatty Acid Oxidation Via the Activation of Adenosine Monophosphate-Activated Protein Kinase-ɑ - Proliferator-Activated Receptor-r Coactivator-1ɑ Signaling in Skeletal Muscle of Mice With Heart Failure," 2020, Circulation Heart Failure

Collaboration has been an integral part of Hisataka Sabe's research activities. Frequent co-authors include Haruka Handa, Shingo Takada, Shintaro Kinugawa, Takashi Yokota, and Ari Hashimoto. This network reflects a multidisciplinary approach to addressing complex biomedical problems.

Best Publications

  • Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

    Z Songyang;S E Shoelson;J McGlade;P Olivier

  • Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.

    M. Takata;H. Sabe;A. Hata;T. Inazu

  • Molecular cloning of cDNA encoding human interleukin-2 receptor

    Toshio Nikaido;Akira Shimizu;Norio Ishida;Hisataka Sabe

  • Requirement for Arf6 in breast cancer invasive activities

    Shigeru Hashimoto;Yasuhito Onodera;Ari Hashimoto;Miwa Tanaka

  • Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion.

    Hajime Yano;Yuichi Mazaki;Kazuo Kurokawa;Steven K. Hanks

  • GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.

    Masaki Morishige;Shigeru Hashimoto;Eiji Ogawa;Yoshinobu Toda

  • Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration

    Asako Tsubouchi;Asako Tsubouchi;Junko Sakakura;Ryohei Yagi;Yuichi Mazaki

  • A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation.

    Akihiko Ito;Tatsuki R. Kataoka;Masafumi Watanabe;Kazutaka Nishiyama

  • Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities

    Yasuhito Onodera;Yasuhito Onodera;Shigeru Hashimoto;Ari Hashimoto;Masaki Morishige;Masaki Morishige

  • Tyrosine Phosphorylation of Paxillin α Is Involved in Temporospatial Regulation of Paxillin-containing Focal Adhesion Formation and F-actin Organization in Motile Cells

    Kuniaki Nakamura;Hajime Yano;Hiroshi Uchida;Shigeru Hashimoto

  • CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B cells

    Shigeru Yanagi;Shigeru Yanagi;Hitoshi Sugawara;Mari Kurosaki;Hisataka Sabe

  • The EGFR‐GEP100‐Arf6‐AMAP1 Signaling Pathway Specific to Breast Cancer Invasion and Metastasis†

    Hisataka Sabe;Shigeru Hashimoto;Masaki Morishige;Masaki Morishige;Eiji Ogawa;Eiji Ogawa

  • A New Paxillin-binding Protein, PAG3/Papα/KIAA0400, Bearing an ADP-Ribosylation Factor GTPase-activating Protein Activity, Is Involved in Paxillin Recruitment to Focal Adhesions and Cell Migration

    Akiko Kondo;Akiko Kondo;Shigeru Hashimoto;Hajime Yano;Kuniaki Nagayama

  • Requirement for Arf6 in Cell Adhesion, Migration, and Cancer Cell Invasion

    Hisataka Sabe

  • Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis

    Shigeru Hashimoto;Mayumi Hirose;Ari Hashimoto;Masaki Morishige

  • Inhibition of Cytokinesis by a Lipid Metabolite, Psychosine

    Takayuki Kanazawa;Sachiko Nakamura;Michiko Momoi;Toshiyuki Yamaji

  • Activation of c-Src in cells bearing v-Crk and its suppression by Csk.

    H Sabe;M Okada;H Nakagawa;H Hanafusa

  • Paxillin associates with poly(A)-binding protein 1 at the dense endoplasmic reticulum and the leading edge of migrating cells.

    Alison J. Woods;Marnie S. Roberts;Jyoti Choudhary;Simon T. Barry

  • RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization.

    Christine Didier;Limor Broday;Anindita Bhoumik;Sharon Israeli

  • Paxillin α and Crk-associated substrate exert opposing effects on cell migration and contact inhibition of growth through tyrosine phosphorylation

    Hajime Yano;Hiroshi Uchida;Teruo Iwasaki;Mutsuko Mukai

Frequent Co-Authors

Tasuku Honjo
Tasuku Honjo Kyoto University
Hidesaburo Hanafusa
Hidesaburo Hanafusa Osaka Bioscience Institute
Masakazu Hatanaka
Masakazu Hatanaka Kyoto University
Hiroyuki Tsutsui
Hiroyuki Tsutsui Kyushu University
Hiroki Shirato
Hiroki Shirato Hokkaido University
Shinya Tanaka
Shinya Tanaka Hokkaido University
Akira Shimizu
Akira Shimizu Kyoto University
Naoki Mochizuki
Naoki Mochizuki National Cerebral and Cardiovascular Center
Masato Okada
Masato Okada Osaka University
Haruhiko Siomi
Haruhiko Siomi Keio University

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