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Crislyn D'Souza-Schorey

Crislyn D'Souza-Schorey

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
29571
World Ranking
15332
National Ranking
6394

Research.com Recognitions

  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Crislyn D'Souza-Schorey is affiliated with the University of Notre Dame in the United States. Their research primarily concerns biochemistry, genetics, and molecular biology, with a significant focus on medicine. Specific subfields include molecular biology, cancer research, cardiology and cardiovascular medicine, pulmonary and respiratory medicine, and immunology and allergy.

The researcher's work frequently centers on several key topics, including:

  • Extracellular vesicles in disease
  • MicroRNA in disease regulation
  • Pulmonary hypertension research and treatments
  • Cardiovascular effects of exercise
  • Cell adhesion molecules research
  • Cardiac tumors and thrombi
  • Nanoplatforms for cancer theranostics

Recent publications by D'Souza-Schorey demonstrate a consistent focus on extracellular vesicles and their role in disease contexts:

  • "The ins and outs of microvesicles," 2021, published in FASEB BioAdvances
  • "Tumor-Derived Extracellular Vesicles: Multifunctional Entities in the Tumor Microenvironment," 2022, published in Annual Review of Pathology Mechanisms of Disease
  • "Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth," 2020, published in Nature Communications
  • "Recruitment of DNA to tumor-derived microvesicles," 2022, published in Cell Reports
  • "Small Extracellular Vesicles From Infarcted and Failing Heart Accelerate Tumor Growth," 2024, published in Circulation

Frequent publication venues for D'Souza-Schorey include:

  • FASEB BioAdvances
  • Circulation
  • Nature Cell Biology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • iScience

The scientist collaborates regularly with a core group of co-authors, including Alex Boomgarden, James Clancy, Tal Caller, Itai Rotem, and Daria Lendengolts, with multiple joint publications across several years.

Recognition within the scientific community includes receipt of the Fellow of the American Association for the Advancement of Science (AAAS) award in 2012.

Best Publications

  • Minimal information for studies of extracellular vesicles 2018 (MISEV2018) : a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

    Clotilde Théry;Kenneth W. Witwer;Elena Aikawa;Maria Jose Alcaraz

  • Rho GTPases and signaling networks

    L Van Aelst;C D'Souza-Schorey

  • ARF proteins: roles in membrane traffic and beyond.

    Crislyn D'Souza-Schorey;Philippe Chavrier

  • Microvesicles: mediators of extracellular communication during cancer progression

    Vandhana Muralidharan-Chari;James W. Clancy;Alanna Sedgwick;Crislyn D'Souza-Schorey

  • ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles.

    Vandhana Muralidharan-Chari;James Clancy;Carolyn Plou;Maryse Romao

  • Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers

    Crislyn D'Souza-Schorey;James W. Clancy

  • A regulatory role for ARF6 in receptor-mediated endocytosis.

    Crislyn D'Souza-Schorey;Guangpu Li;Maria I. Colombo;Philip D. Stahl

  • Biology and biogenesis of shed microvesicles.

    Christopher Tricarico;James Clancy;Crislyn D'Souza-Schorey

  • Large Oncosomes in Human Prostate Cancer Tissues and in the Circulation of Mice with Metastatic Disease

    Dolores Di Vizio;Dolores Di Vizio;Dolores Di Vizio;Matteo Morello;Matteo Morello;Matteo Morello;Andrew C. Dudley;Peter W. Schow

  • Lysosomal targeting of E-cadherin: a unique mechanism for the down-regulation of cell-cell adhesion during epithelial to mesenchymal transitions

    Felipe Palacios;Jogender S. Tushir;Yasuyuki Fujita;Crislyn D'Souza-Schorey

  • ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassembly

    Felipe Palacios;Jill K. Schweitzer;Rita L. Boshans;Crislyn D'Souza-Schorey

  • The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA

    Mika Sakurai-Yageta;Mika Sakurai-Yageta;Chiara Recchi;Chiara Recchi;Gaëlle Le Dez;Gaëlle Le Dez;Jean Baptiste Sibarita;Jean Baptiste Sibarita

  • An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration.

    Felipe Palacios;Leo Price;Leo Price;Jill Schweitzer;John G. Collard

  • EFA6, a sec7 domain-containing exchange factor for ARF6, coordinates membrane recycling and actin cytoskeleton organization

    Michel Franco;Peter J. Peters;Joëlle Boretto;Elly van Donselaar

  • Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5

    Guangpu Li;C. D'souza-Schorey;M. A. Barbieri;R. L. Roberts

  • A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements.

    Crislyn D'Souza‐Schorey;Rita L. Boshans;Michelle McDonough;Philip D. Stahl

  • ARF6 Targets Recycling Vesicles to the Plasma Membrane: Insights from an Ultrastructural Investigation

    Crislyn D'Souza-Schorey;Elly van Donselaar;Victor W. Hsu;Chunzhi Yang

  • Disassembling adherens junctions: breaking up is hard to do.

    Crislyn D'Souza-Schorey

  • ADP-ribosylation factor 6 regulates actin cytoskeleton remodeling in coordination with Rac1 and RhoA.

    Rita L. Boshans;Stacey Szanto;Linda van Aelst;Crislyn D'Souza-Schorey

  • The biology of extracellular microvesicles

    Alanna E. Sedgwick;Crislyn D'Souza-Schorey

Frequent Co-Authors

Philip D. Stahl
Philip D. Stahl Washington University in St. Louis
Philippe Chavrier
Philippe Chavrier Institute Curie
Peter J. Peters
Peter J. Peters Maastricht University
Graça Raposo
Graça Raposo Institut Curie
Harikrishna Nakshatri
Harikrishna Nakshatri Indiana University
Linda Van Aelst
Linda Van Aelst Cold Spring Harbor Laboratory
Neil A. Bhowmick
Neil A. Bhowmick Cedars-Sinai Medical Center
Hong Wu
Hong Wu Peking University
Ralph R. Isberg
Ralph R. Isberg Tufts University
Michael R. Freeman
Michael R. Freeman Cedars-Sinai Medical Center

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