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Hiroyuki Sakagami

Hiroyuki Sakagami

D-Index & Metrics

Neuroscience

D-Index
48
Citations
7651
World Ranking
6238
National Ranking
205

Overview

Hiroyuki Sakagami is affiliated with Kitasato University in Japan and specializes in research spanning the fields of biochemistry, genetics, and molecular biology, with an additional focus on medicine. Their scientific contributions encompass 53 publications in biochemistry, genetics, and molecular biology and 20 in medicine.

Their primary research interests involve subfields such as molecular biology, cell biology, cellular and molecular neuroscience, surgery, and genetics. These areas of study support a wide array of topics which include cellular transport and secretion, protein kinase regulation and GTPase signaling, pancreatic function and diabetes, genetics and neurodevelopmental disorders, metabolism, diabetes and cancer, neuroscience and neuropharmacology research, and ion channel regulation and function.

Recent publications by Sakagami show a focus on molecular signaling pathways, neurobiology, and cardiac and muscular system studies. Notable papers include:

  • Molecular Mechanisms Underlying Ca2+/Calmodulin-Dependent Protein Kinase Kinase Signal Transduction, 2022, International Journal of Molecular Sciences
  • Canagliflozin Suppresses Atrial Remodeling in a Canine Atrial Fibrillation Model, 2021, Journal of the American Heart Association
  • Brain Dp140 Alters Glutamatergic Transmission and Social Behaviour in the mdx52 Mouse Model of Duchenne Muscular Dystrophy, 2022, Progress in Neurobiology
  • Nicotine Rescues Depressive-like Behaviors via α7-type Nicotinic Acetylcholine Receptor Activation in CaMKIV Null Mice, 2020, Molecular Neurobiology
  • BRAG2a Mediates mGluR-Dependent AMPA Receptor Internalization at Excitatory Postsynapses through the Interaction with PSD-95 and Endophilin 3, 2020, Journal of Neuroscience

Sakagami frequently collaborates with a group of co-authors, including Masahiro Fukaya, Hiroshi Tokumitsu, Yoshinobu Hara, Takeyuki Sugawara, and Surang Chomphoo. These collaborations contribute to an extensive body of work in molecular biology and related fields.

They have published multiple articles in certain venues repeatedly, indicating a pattern of research dissemination. These frequent publication venues include Acta Histochemica, International Journal of Molecular Sciences, Molecular Neurobiology, Biochemical and Biophysical Research Communications, and Journal of Anatomy.

Best Publications

  • Localization of mRNAs of voltage-dependent Ca2+-channels: four subtypes of α1- and β-subunits in developing and mature rat brain

    Osamu Tanaka;Hiroyuki Sakagami;Hisatake Kondo

  • ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons

    Lidong Liu;Jane E. Cavanaugh;Yupeng Wang;Hiroyuki Sakagami

  • Kinase-Dead Knock-In Mouse Reveals an Essential Role of Kinase Activity of Ca2+/Calmodulin-Dependent Protein Kinase IIα in Dendritic Spine Enlargement, Long-Term Potentiation, and Learning

    Yoko Yamagata;Shizuka Kobayashi;Tatsuya Umeda;Akihiro Inoue

  • Fluorescent labeling of both GABAergic and glycinergic neurons in vesicular GABA transporter (VGAT)-venus transgenic mouse

    Y. Wang;T. Kakizaki;H. Sakagami;K. Saito;K. Saito

  • Altered emotional behavioral responses in mice lacking brain-type fatty acid-binding protein gene.

    Yuji Owada;Soha Abdelkawi Abdelwahab;Noriko Kitanaka;Hiroyuki Sakagami

  • CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility

    Kosuke Okuda;Shizuka Kobayashi;Masahiro Fukaya;Aya Watanabe

  • COX-2 and Prostaglandin EP3/EP4 Signaling Regulate the Tumor Stromal Proangiogenic Microenvironment via CXCL12-CXCR4 Chemokine Systems

    Hiroshi Katoh;Kanako Hosono;Yoshiya Ito;Tatsunori Suzuki

  • Regulation of long-term potentiation by H-Ras through NMDA receptor phosphorylation.

    Toshiya Manabe;Toshiya Manabe;Atsu Aiba;Atsushi Yamada;Taeko Ichise

  • Immunohistochemical distribution and functional characterization of an organic anion transporting polypeptide 2 (oatp2).

    Masayuki Kakyo;Hiroyuki Sakagami;Toshiyuki Nishio;Daisuke Nakai

  • Importin α transports CaMKIV to the nucleus without utilizing importin β

    Ippei Kotera;Toshihiro Sekimoto;Yoichi Miyamoto;Takuya Saiwaki

  • Coexpression of junctophilin type 3 and type 4 in brain.

    Miyuki Nishi;Hiroyuki Sakagami;Shinji Komazaki;Hisatake Kondo

  • Vascular endothelial growth factor receptor-1 signaling promotes liver repair through restoration of liver microvasculature after acetaminophen hepatotoxicity

    Tetsuki Kato;Yoshiya Ito;Kanako Hosono;Tatsunori Suzuki

  • Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins

    Shigeki Moriguchi;Miyuki Nishi;Shinji Komazaki;Hiroyuki Sakagami

  • IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses

    Hiroyuki Sakagami;Masashi Sanda;Masashi Sanda;Masahiro Fukaya;Taisuke Miyazaki

  • Roles of Prostaglandin E2–EP3/EP4 Receptor Signaling in the Enhancement of Lymphangiogenesis During Fibroblast Growth Factor-2–Induced Granulation Formation

    Kanako Hosono;Tatsunori Suzuki;Hideaki Tamaki;Hiroyuki Sakagami

  • USP9x‐mediated deubiquitination of EFA6 regulates de novo tight junction assembly

    Delphine Theard;Florian Labarrade;Mariagrazia Partisani;Julie Milanini

  • Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity

    Sho Kakizawa;Yasushi Kishimoto;Kouichi Hashimoto;Taisuke Miyazaki

  • Comprehensive Behavioral Analysis of Calcium/Calmodulin-Dependent Protein Kinase IV Knockout Mice

    Keizo Takao;Keizo Takao;Koichi Tanda;Kenji Nakamura;Jiro Kasahara;Jiro Kasahara

  • Distinct immunohistochemical localization of two isoforms of Ca2+/calmodulin-dependent protein kinase kinases in the adult rat brain.

    Hiroyuki Sakagami;Masashi Umemiya;Sachiko Saito;Hisatake Kondo

  • Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family

    Taisuke Miyazaki;Kouichi Hashimoto;Atsushi Uda;Hiroyuki Sakagami

  • Extracellular signal-regulated kinase (ERK) 5 is necessary and sufficient to specify cortical neuronal fate

    Lidong Liu;Paige Cundiff;Glen Abel;Yupeng Wang

  • Interaction of LDL receptor‐related protein 4 (LRP4) with postsynaptic scaffold proteins via its C‐terminal PDZ domain‐binding motif, and its regulation by Ca2+/calmodulin‐dependent protein kinase II

    Qing-Bao Tian;Tatsuo Suzuki;Takashi Yamauchi;Hiroyuki Sakagami

  • SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses

    Masahiro Fukaya;Akifumi Kamata;Yoshinobu Hara;Hideaki Tamaki

Frequent Co-Authors

Masahiro Fukaya
Masahiro Fukaya Kitasato University
Masahiko Watanabe
Masahiko Watanabe Hokkaido University
Yuchio Yanagawa
Yuchio Yanagawa Gunma University
Toshiya Manabe
Toshiya Manabe University of Tokyo
Taisuke Miyazaki
Taisuke Miyazaki Hokkaido University
Tsuyoshi Miyakawa
Tsuyoshi Miyakawa Fujita Health University
Kunihiko Obata
Kunihiko Obata The Graduate University for Advanced Studies, SOKENDAI
Masanobu Kano
Masanobu Kano University of Tokyo
Kouichi Hashimoto
Kouichi Hashimoto Hiroshima University
Keizo Takao
Keizo Takao University of Toyama

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