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Biology and Biochemistry
Australia
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
79
Citations
35511
World Ranking
4210
National Ranking
102

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Australia Leader Award
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

David Komander is affiliated with the Walter and Eliza Hall Institute of Medical Research in Australia. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with notable contributions in Medicine.

They have a significant focus on subfields such as Molecular Biology, Epidemiology, Oncology, Infectious Diseases, and Immunology. Their work covers multiple topics, including:

  • Ubiquitin and proteasome pathways
  • Autophagy in Disease and Therapy
  • Interferon and immune responses
  • SARS-CoV-2 and COVID-19 Research
  • NF-κB Signaling Pathways
  • Cancer-related Molecular Pathways
  • Peptidase Inhibition and Analysis

David Komander's publications appear frequently in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The EMBO Journal
  • Life Science Alliance
  • Nature Communications
  • Cell Death and Differentiation

Among recent papers, several key works include:

  • "Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2" (2020, The EMBO Journal)
  • "Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities" (2021, Cell Death and Differentiation)
  • "Deubiquitinases in cancer" (2023, Nature Reviews. Cancer)
  • "Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling" (2020, Molecular Cell)
  • "Activation mechanism of PINK1" (2021, Nature)

Komander frequently collaborates with several other researchers, including:

  • Grant Dewson
  • Dale J. Calleja
  • Zhong Yan Gan
  • Bernadine G.C. Lu
  • Kym N. Lowes

David Komander has been recognized as a Member of the European Molecular Biology Organization (EMBO), reflecting a level of professional acknowledgment within the scientific community.

Best Publications

  • The Ubiquitin Code

    David Komander;Michael Rape

  • Breaking the chains: structure and function of the deubiquitinases.

    David Komander;Michael J. Clague;Sylvie Urbé

  • The nuts and bolts of AGC protein kinases

    Laura R. Pearce;David Komander;Dario R. Alessi

  • The emerging complexity of protein ubiquitination

    David Komander

  • PDK1, the master regulator of AGC kinase signal transduction.

    Alfonso Mora;David Komander;Daan M.F. van Aalten;Dario R. Alessi

  • Mechanisms of Deubiquitinase Specificity and Regulation

    Tycho E.T. Mevissen;David Komander

  • Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation

    Simin Rahighi;Simin Rahighi;Fumiyo Ikeda;Masato Kawasaki;Masato Kawasaki;Masato Akutsu;Masato Akutsu;Masato Akutsu

  • Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

    Tobias L. Haas;Christoph H. Emmerich;Christoph H. Emmerich;Bjã¶rn Gerlach;Bjã¶rn Gerlach;Anna C. Schmukle

  • Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

    Yogesh Kulathu;David Komander

  • Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

    David Komander;David Komander;Francisca Reyes‐Turcu;Julien D F Licchesi;Peter Odenwaelder

  • Breaking the chains: deubiquitylating enzyme specificity begets function.

    Michael J Clague;Sylvie Urbé;David Komander

  • OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.

    Tycho E.T. Mevissen;Manuela K. Hospenthal;Paul P. Geurink;Paul R. Elliott

  • Structural insights into the catalytic mechanism of a family 18 exo-chitinase

    D. M. F. van Aalten;D. Komander;B. Synstad;S. Gåseidnes

  • Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.

    Theresa Klemm;Gregor Ebert;Dale J Calleja;Cody C Allison

  • OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin

    Kirstin Keusekotten;Paul Ronald Elliott;Laura Glockner;Berthe Katrine Fiil

  • Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

    Christoph H. Emmerich;Alban Ordureau;Sam Strickson;J. Simon C. Arthur

  • Mechanism of phospho-ubiquitin-induced PARKIN activation.

    Tobias Wauer;Michal Simicek;Alexander Schubert;David Komander

  • Molecular basis of USP7 inhibition by selective small-molecule inhibitors

    Andrew P. Turnbull;Stephanos Ioannidis;Wojciech W. Krajewski;Adan Pinto-Fernandez

  • Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne.

    Anja Bremm;Stefan M V Freund;David Komander

  • Mechanism of parkin activation by PINK1

    Christina Gladkova;Sarah L. Maslen;J. Mark Skehel;David Komander

Frequent Co-Authors

Stefan M.V. Freund
Stefan M.V. Freund MRC Laboratory of Molecular Biology
Huib Ovaa
Huib Ovaa Leiden University Medical Center
Dario R. Alessi
Dario R. Alessi University of Dundee
Maria Deak
Maria Deak University of Dundee
Daan M. F. van Aalten
Daan M. F. van Aalten University of Dundee
Benedikt M. Kessler
Benedikt M. Kessler University of Oxford
Michael J. Clague
Michael J. Clague University of Liverpool
Sylvie Urbé
Sylvie Urbé University of Liverpool
Felix Randow
Felix Randow MRC Laboratory of Molecular Biology
David Barford
David Barford MRC Laboratory of Molecular Biology

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