Maria Deak

Overview

Best Publications

• LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

  Jose M Lizcano;Olga Göransson;Rachel Toth;Maria Deak

  1558
  Citations

• Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

  Maria Deak;Andrew D. Clifton;John M. Lucocq;Dario R. Alessi

  1284
  Citations

• 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.

  Dario R. Alessi;Maria Deak;Antonio Casamayor;F. Barry Caudwell

  986
  Citations

• PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

  Chandana Kondapalli;Agne Kazlauskaite;Ning Zhang;Helen I. Woodroof

  921
  Citations

• Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities.

  S Dowler;R A Currie;D G Campbell;M Deak

  778
  Citations

• The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

  Alberto C. Vitari;Maria Deak;Nick A. Morrice;Dario R. Alessi

  668
  Citations

• LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity.

  Mahaboobi Jaleel;R. Jeremy Nichols;Maria Deak;David G. Campbell

  616
  Citations

• Identification of Protor as a novel Rictor-binding component of mTOR complex-2

  Laura R. Pearce;Xu Huang;Jérôme Boudeau;Rafał Pawłowski

  597
  Citations

• PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2

  Anudharan Balendran;Antonio Casamayor;Maria Deak;Andrew Paterson

  594
  Citations

• Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase.

  Takayasu Kobayashi;Maria Deak;Nick Morrice;Philip Cohen

  569
  Citations

• MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

  Jérôme Boudeau;Annette F. Baas;Maria Deak;Nick A. Morrice

  535
  Citations

• Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.

  R A Currie;K S Walker;A Gray;M Deak

  508
  Citations

• The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

  Ricardo M. Biondi;Agnieszka Kieloch;Richard A. Currie;Maria Deak

  447
  Citations

• 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

  R. Jeremy Nichols;Nicolas Dzamko;Nicholas A. Morrice;David G. Campbell

  418
  Citations

• Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization

  Nicolas Dzamko;Maria Deak;Faycal Hentati;Alastair D. Reith

  407
  Citations

• High-Resolution Structure of the Pleckstrin Homology Domain of Protein Kinase B/Akt Bound to Phosphatidylinositol (3,4,5)-Trisphosphate

  Christine C Thomas;Maria Deak;Dario R Alessi;Daan M.F van Aalten

  406
  Citations

• Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.

  Kay S. Walker;Maria Deak;Andrew Paterson;Kevin Hudson

  400
  Citations

• Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.

  Alberto C. Vitari;Jacob Thastrup;Fatema H. Rafiqi;Maria Deak

  396
  Citations

• Structure of the Lkb1-Strad-Mo25 Complex Reveals an Allosteric Mechanism of Kinase Activation.

  Elton Zeqiraj;Beatrice Maria Filippi;Maria Deak;Dario R. Alessi

  391
  Citations

• Phosphorylation of the Protein Kinase Mutated in Peutz-Jeghers Cancer Syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent Protein Kinase, but Not Its Farnesylation at Cys433, Is Essential for LKB1 to Suppress Cell Growth

  Gopal P. Sapkota;Agnieszka Kieloch;Jose M. Lizcano;Sonia Lain

  386
  Citations