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2025
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Biology and Biochemistry
UK
2026

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Best Scientists

D-Index
184
Citations
158661
World Ranking
520
National Ranking
55

Biology and Biochemistry

D-Index
184
Citations
161058
World Ranking
61
National Ranking
2

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2022 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2008 - Member of the National Academy of Sciences
  • 1990 - Member of Academia Europaea
  • 1984 - Fellow of the Royal Society of Edinburgh
  • 1984 - Fellow of the Royal Society, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Philip Cohen is affiliated with the University of Dundee in the United Kingdom. Their research spans multiple disciplines, primarily within biochemistry, genetics, and molecular biology, with significant contributions to medicine and immunology and microbiology.

Their work has focused on specific subfields such as molecular biology, immunology, cancer research, oncology, and rheumatology. Key topics in their research include ubiquitin and proteasome pathways, NF-κB signaling pathways, interferon and immune responses, immune cell function and interaction, immune cells in cancer, melanoma and MAPK pathways, and PI3K/AKT/mTOR signaling in cancer.

Prominent publication venues where Philip Cohen has frequently contributed include bioRxiv (Cold Spring Harbor Laboratory), Biochemical Journal, Journal of Biological Chemistry, Lupus Science & Medicine, and Nature Reviews Drug Discovery.

They have collaborated extensively with several coauthors, notably Sambit K. Nanda, Tom Snelling, Nicola T. Wood, Nicola J. Darling, and Cheryl L. Scudamore.

Among recent publications, the following are notable:

  • Kinase drug discovery 20 years after imatinib: progress and future directions, 2021, Nature Reviews Drug Discovery
  • HOIL-1 ubiquitin ligase activity targets unbranched glucosaccharides and is required to prevent polyglucosan accumulation, 2022, The EMBO Journal
  • Nuts and bolts of the salt-inducible kinases (SIKs), 2021, Biochemical Journal
  • IKKβ is required for the formation of the NLRP3 inflammasome, 2021, EMBO Reports
  • Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation, 2020, Structure

Philip Cohen has been recognized through multiple honors, including membership in the National Academy of Sciences (2008), Academia Europaea (1990), and the European Molecular Biology Organization (EMBO). They are also a Fellow of the Royal Society, United Kingdom (1984), Fellow of the Royal Society of Edinburgh (1984), and Fellow of The Academy of Medical Sciences, United Kingdom.

Best Publications

  • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.

    Darren A. E. Cross;Dario R. Alessi;Philip Cohen;Mirjana Andjelkovich

  • Specificity and mechanism of action of some commonly used protein kinase inhibitors

    Stephen P. Davies;Helen Reddy;Matilde Caivano;Philip Cohen

  • PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

    Dario R. Alessi;Ana Cuenda;Philip Cohen;David T. Dudley

  • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

    Dario R. Alessi;Stephen R. James;C.Peter Downes;Andrew B. Holmes

  • The ground state of embryonic stem cell self-renewal

    Qi-Long Ying;Jason Wray;Jennifer Nichols;Laura Batlle-Morera

  • Mechanism of activation of protein kinase B by insulin and IGF-1.

    Dario R. Alessi;Mirjana Andjelkovic;Barry Caudwell;Peter Cron

  • THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

    Philip Cohen

  • The selectivity of protein kinase inhibitors: a further update.

    Jenny Bain;Lorna Plater;Matt Elliott;Natalia Shpiro

  • Protein kinases--the major drug targets of the twenty-first century?

    Philip Cohen

  • SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

    Ana Cuenda;John Rouse;Yair N. Doza;Roger Meier

  • A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins.

    John Rouse;Philip Cohen;Sylviane Trigon;Michel Morange

  • Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants.

    Carol MacKintosh;Kenneth A. Beattie;Susanne Klumpp;Philip Cohen

  • The renaissance of GSK3.

    Philip Cohen;Sheelagh Frame

  • GSK3 takes centre stage more than 20 years after its discovery.

    Sheelagh Frame;Philip Cohen

  • Okadaic acid: a new probe for the study of cellular regulation.

    Philip Cohen;Charles F.B. Holmes;Yasumasa Tsukitani

  • The specificities of protein kinase inhibitors: an update.

    Jenny Bain;Hilary McLauchlan;Matthew Elliott;Philip Cohen

  • The regulation of protein function by multisite phosphorylation--a 25 year update.

    Philip Cohen

  • The role of protein phosphorylation in neural and hormonal control of cellular activity

    Philip Cohen

  • The origins of protein phosphorylation

    Philip Cohen

  • Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

    J. Ann Le Good;Wolfgang H. Ziegler;Davey B. Parekh;Dario R. Alessi

Frequent Co-Authors

David G. Campbell
David G. Campbell University of Adelaide
Mark Peggie
Mark Peggie University of Dundee
Dario R. Alessi
Dario R. Alessi University of Dundee
J. Simon C. Arthur
J. Simon C. Arthur University of Dundee
Michel Goedert
Michel Goedert MRC Laboratory of Molecular Biology
Nathanael S. Gray
Nathanael S. Gray Stanford University
Brian A. Hemmings
Brian A. Hemmings Friedrich Miescher Institute
Axel Knebel
Axel Knebel University of Dundee
James R. Woodgett
James R. Woodgett Lunenfeld-Tanenbaum Research Institute

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