World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
10823
World Ranking
17532
National Ranking
1382

Overview

Axel Knebel is affiliated with the University of Dundee in the United Kingdom and has contributed extensively to research in biochemistry, genetics, and molecular biology, with additional work in medicine. Their research predominantly focuses on ubiquitin and proteasome pathways, peptidase inhibition and analysis, cellular transport and secretion, autophagy in disease and therapy, glycosylation and glycoproteins research, cancer-related molecular pathways, and protein degradation and inhibitors.

Knebel's publication record includes papers across several respected journals and platforms. Notable recent papers include:

  • HOIL-1 ubiquitin ligase activity targets unbranched glucosaccharides and is required to prevent polyglucosan accumulation, 2022, The EMBO Journal
  • Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation, 2022, Cell Reports
  • High-throughput matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry-based deubiquitylating enzyme assay for drug discovery, 2020, Nature Protocols
  • Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2, 2021, Molecular Cell
  • VCP/p97-associated proteins are binders and debranching enzymes of K48-K63-branched ubiquitin chains, 2024, Nature Structural & Molecular Biology

Their frequent collaborators include Virginia De Cesare, Frédéric Lamoliatte, Yogesh Kulathu, Sven M. Lange, and Miratul M. K. Muqit.

Knebel has published most often in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zenodo (CERN European Organization for Nuclear Research)
  • The EMBO Journal
  • Cell Reports
  • Nature Structural & Molecular Biology

Their main fields of study are:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields of study in which they have published include:

  • Molecular Biology
  • Oncology
  • Cell Biology
  • Epidemiology
  • Spectroscopy

The main topics they have worked on include:

  • Ubiquitin and proteasome pathways
  • Peptidase Inhibition and Analysis
  • Cellular transport and secretion
  • Autophagy in Disease and Therapy
  • Glycosylation and Glycoproteins Research
  • Cancer-related Molecular Pathways
  • Protein Degradation and Inhibitors

Best Publications

  • PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

    Chandana Kondapalli;Agne Kazlauskaite;Ning Zhang;Helen I. Woodroof

  • Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.

    Agne Kazlauskaite;Chandana Kondapalli;Robert Gourlay;David G. Campbell

  • LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity.

    Mahaboobi Jaleel;R. Jeremy Nichols;Maria Deak;David G. Campbell

  • UV-Induced Signal Transduction

    Klaus Bender;Christine Blattner;Axel Knebel;Mihail Iordanov

  • Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

    Maria Stella Ritorto;Richard Ewan;Ana B. Perez-Oliva;Axel Knebel

  • A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38δ

    Axel Knebel;Nick Morrice;Philip Cohen

  • The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents.

    Dagmar Wilhelm;Klaus Bender;Axel Knebel;Peter Angel

  • GSK-3 Phosphorylation of the Alzheimer Epitope within Collapsin Response Mediator Proteins Regulates Axon Elongation in Primary Neurons

    Adam R. Cole;Axel Knebel;Nick A. Morrice;Laura A. Robertson

  • UBQLN2 mediates autophagy-independent protein aggregate clearance by the proteasome

    Roland Hjerpe;John S. Bett;John S. Bett;Matthew J. Keuss;Alexandra Solovyova

  • The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

    Akihito Ohta;Frances-Rose Schumacher;Youcef Mehellou;Clare Johnson

  • The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system.

    Sam Strickson;David G. Campbell;Christoph H. Emmerich;Axel Knebel

  • Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

    Agne Kazlauskaite;R. Julio Martinez-Torres;Scott Wilkie;Atul Kumar

  • Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

    Kuan-Chuan Pao;Nicola T. Wood;Axel Knebel;Karim Rafie

  • Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.

    Atul Kumar;Jacob D Aguirre;Tara E C Condos;R Julio Martinez-Torres

  • Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells

    Andreas Herrlich;Henrik Daub;Axel Knebel;Peter Herrlich

  • The E3 ligase HOIL-1 catalyses ester bond formation between ubiquitin and components of the Myddosome in mammalian cells.

    Ian R. Kelsall;Jiazhen Zhang;Axel Knebel;J. Simon C. Arthur

  • KESTREL: a powerful method for identifying the physiological substrates of protein kinases.

    Philip Cohen;Axel Knebel

  • Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.

    Atul Kumar;Viduth K Chaugule;Tara E C Condos;Kathryn R Barber

  • CSN- and CAND1-dependent remodelling of the budding yeast SCF complex.

    Aleksandra Zemla;Yann Thomas;Sylwia Kedziora;Axel Knebel

  • Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling

    Sam Strickson;Christoph H. Emmerich;Eddy T. H. Goh;Jiazhen Zhang

Frequent Co-Authors

Matthias Trost
Matthias Trost Newcastle University
Philip Cohen
Philip Cohen University of Dundee
Peter Herrlich
Peter Herrlich Leibniz Association
Dario R. Alessi
Dario R. Alessi University of Dundee
Kay Hofmann
Kay Hofmann University of Cologne
Rachel Toth
Rachel Toth University of Dundee
Mark Peggie
Mark Peggie University of Dundee
Alan R. Prescott
Alan R. Prescott University of Dundee
J. Simon C. Arthur
J. Simon C. Arthur University of Dundee

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