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Biology and Biochemistry

D-Index
72
Citations
19132
World Ranking
6283
National Ranking
406

Overview

Shinichi Uchida is affiliated with Tokyo Medical and Dental University in Japan. Their research primarily concentrates on the medical and biochemical aspects of kidney function and disease, with a significant focus on molecular biology and nephrology. This work intersects with related fields such as pulmonary and respiratory medicine, genetics, and physiology.

The scholar has published extensively within the fields of medicine and biochemistry, genetics, and molecular biology, contributing to a total of 157 and 83 publications respectively. Within these broad disciplines, their subfield specializations include molecular biology, nephrology, pulmonary and respiratory medicine, genetics, and physiology.

Their scientific investigations predominantly address topics such as ion transport and channel regulation, renal and related cancers, renal diseases and glomerulopathies, genetic and kidney cyst diseases, electrolyte and hormonal disorders, dialysis and renal disease management, and hormonal regulation and hypertension.

Frequent co-authors in these studies include Takayasu Mori, Eisei Sohara, Shintaro Mandai, Koichiro Susa, and Fumiaki Ando, indicating continued collaborative efforts in related biomedical research areas.

Uchida's work has been published in numerous scientific venues, with notable frequent appearances in the Journal of the American Society of Nephrology, bioRxiv (Cold Spring Harbor Laboratory), CEN Case Reports, Journal of Renal Nutrition, and BMC Nephrology.

Some recent representative papers authored or co-authored by Uchida are:

  • "Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease," 2023, Circulation Research
  • "Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease," 2020, Kidney International
  • "The WNK signaling pathway and salt-sensitive hypertension," 2020, Hypertension Research
  • "Chronic kidney disease causes blood-brain barrier breakdown via urea-activated matrix metalloproteinase-2 and insolubility of tau protein," 2023, Aging
  • "Effect of osteosarcopenia on longitudinal mortality risk and chronic kidney disease progression in older adults," 2023, Bone

Best Publications

  • Cloning and expression of apical membrane water channel of rat kidney collecting tubule

    K Fushimi;S Uchida;Y Hara;Y Hirata

  • Molecular cloning and expression of a member of the aquaporin family with permeability to glycerol and urea in addition to water expressed at the basolateral membrane of kidney collecting duct cells

    K Ishibashi;S Sasaki;K Fushimi;S Uchida

  • WNK1 Regulates Phosphorylation of Cation-Chloride-coupled Cotransporters via the STE20-related Kinases, SPAK and OSR1

    Tetsuo Moriguchi;Seiichi Urushiyama;Naoki Hisamoto;Shun Ichiro Iemura

  • Molecular cloning of the cDNA for an MDCK cell Na(+)- and Cl(-)-dependent taurine transporter that is regulated by hypertonicity.

    S Uchida;H M Kwon;A Yamauchi;A S Preston

  • Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins

    Kozue Yamauchi;Tatemitsu Rai;Katsuki Kobayashi;Eisei Sohara

  • Molecular Pathogenesis of Pseudohypoaldosteronism Type II: Generation and Analysis of a Wnk4D561A/+ Knockin Mouse Model

    Sung-Sen Yang;Tetsuji Morimoto;Tatemitsu Rai;Motoko Chiga

  • Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla.

    S Uchida;S Sasaki;T Furukawa;M Hiraoka

  • Transcriptional regulation of aquaporin-2 water channel gene by cAMP.

    Y Matsumura;S Uchida;T Rai;S Sasaki

  • Cloning and expression of a protein kinase C-regulated chloride channel abundantly expressed in rat brain neuronal cells.

    Masanobu Kawasaki;Shinichi Uchida;Toshiaki Monkawa;Toshiaki Monkawa;Atsushi Miyawaki

  • Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation.

    Mariko Hara-Chikuma;Eisei Sohara;Tatemitsu Rai;Masahito Ikawa

  • SPAK-Knockout Mice Manifest Gitelman Syndrome and Impaired Vasoconstriction

    Sung-Sen Yang;Yi-Fen Lo;Chin-Chen Wu;Shu-Wha Lin

  • Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells

    Tomohiro Itoh;Tatemitsu Rai;Michio Kuwahara;Shigeru B.H. Ko

  • Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel

    Yoshihiro Matsumura;Shinichi Uchida;Yoshiaki Kondo;Hiroaki Miyazaki

  • Localization and functional characterization of rat kidney-specific chloride channel, ClC-K1.

    S Uchida;S Sasaki;K Nitta;K Uchida

  • Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone

    Motoko Chiga;Tatemitsu Rai;Sung-Sen Yang;Akihito Ohta

  • Expression and phosphorylation of the Na-Cl cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1

    Volker Vallon;Jana Schroth;Florian Lang;Dietmar Kuhl

  • ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation.

    Mariko Hara-Chikuma;Baoxue Yang;N.D. Sonawane;Sei Sasaki

  • Induction of aldose reductase and sorbitol in renal inner medullary cells by elevated extracellular NaCl.

    Serena M. Bagnasco;Shunya Uchida;Robert S. Balaban;Peter F. Kador

  • Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.

    Mai Wakabayashi;Takayasu Mori;Kiyoshi Isobe;Eisei Sohara

  • WNK1 Regulates Phosphorylation of Cation-Chloride- coupled Cotransporters via the STE20-related Kinases,

    Tetsuo Moriguchi;Seiichi Urushiyama;Naoki Hisamoto;Shun-ichiro Iemura

Frequent Co-Authors

Sei Sasaki
Sei Sasaki Tokyo Medical and Dental University
Fumiaki Marumo
Fumiaki Marumo Tokyo Medical and Dental University
Kenichi Ishibashi
Kenichi Ishibashi Meiji Pharmaceutical University
Hiroyuki Kagechika
Hiroyuki Kagechika Tokyo Medical and Dental University
Dario R. Alessi
Dario R. Alessi University of Dundee
Eric Delpire
Eric Delpire Vanderbilt University
David H. Ellison
David H. Ellison Oregon Health & Science University
Hiroshi Shibuya
Hiroshi Shibuya Tokyo Medical and Dental University
Shigeaki Nonoyama
Shigeaki Nonoyama National Defense Medical College

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