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Kristopher T. Kahle

Kristopher T. Kahle

D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
16315
World Ranking
6724
National Ranking
3121

Overview

Kristopher T. Kahle is affiliated with Yale University in the United States and has made significant contributions across several areas of medicine and neuroscience. Their research has primarily focused on neurological disorders, with a particular emphasis on cerebrospinal fluid dynamics and hydrocephalus.

Their recent publications include the following papers:

  • Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus, 2020, Trends in Molecular Medicine
  • Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets, 2020, Nature Reviews Neurology
  • Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus, 2020, Nature Medicine
  • The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus, 2023, Cell
  • Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a, 2020, Nature Communications

Frequently collaborating with other researchers, Kahle's prominent co-authors include:

  • Phan Q. Duy
  • Adam J. Kundishora
  • Sheng Chih Jin
  • Seth L. Alper
  • Benjamin C. Reeves

The scientist often publishes in journals and venues such as:

  • Neurosurgery
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cerebral Cortex
  • Journal of Neurosurgery Pediatrics
  • World Neurosurgery

Kahle's work spans multiple fields of study with a total of nearly 200 publications in medicine, alongside extensive work in biochemistry, genetics, and molecular biology. Neuroscience is another major area of focus, which includes investigations into cellular and molecular neuroscience and neurology subfields.

Specific subfields of their research include:

  • Neurology
  • Genetics
  • Cellular and Molecular Neuroscience
  • Pediatrics, Perinatology and Child Health
  • Molecular Biology

Their main research topics cover a spectrum of neurological and developmental disorders:

  • Cerebrospinal fluid and hydrocephalus
  • Fetal and Pediatric Neurological Disorders
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Genetic and Kidney Cyst Diseases
  • Craniofacial Disorders and Treatments
  • Spinal Dysraphism and Malformations
  • Neuroscience and Neuropharmacology Research

Best Publications

  • The GABA Excitatory/Inhibitory Shift in Brain Maturation and Neurological Disorders:

    Yehezkel Ben-Ari;Ilgam Khalilov;Kristopher T Kahle;Enrico Cherubini

  • A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis.

    Jessica D. Kessler;Kristopher T. Kahle;Kristopher T. Kahle;Tingting Sun;Kristen L. Meerbrey

  • Roles of the cation–chloride cotransporters in neurological disease

    Kristopher T Kahle;Kevin J Staley;Brian V Nahed;Gerardo Gamba

  • Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4.

    Frederick H. Wilson;Kristopher T. Kahle;Ernesto Sabath;Maria D. Lalioti

  • WNK4 regulates the balance between renal NaCl reabsorption and K + secretion

    Kahle Kt;Wilson Fh;Wilson Fh;Leng Q;Lalioti;Lalioti

  • Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule.

    Maria D Lalioti;Junhui Zhang;Heather M Volkman;Kristopher T Kahle

  • EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer

    April F. Eichler;Kristopher T. Kahle;Daphne L. Wang;Victoria A. Joshi

  • Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus

    Jason K Karimy;Jinwei Zhang;Jinwei Zhang;David B Kurland;Brianna Carusillo Theriault

  • Molecular mechanisms of ischemic cerebral edema: role of electroneutral ion transport.

    Kristopher T. Kahle;J. Marc Simard;Kevin J. Staley;Brian V. Nahed

  • Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus.

    Benjamin C. Reeves;Jason K. Karimy;Adam J. Kundishora;Humberto Mestre

  • The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters

    Dario R. Alessi;Jinwei Zhang;Arjun Khanna;Thomas Hochdörfer

  • WNK3 modulates transport of Cl- in and out of cells: Implications for control of cell volume and neuronal excitability

    Kristopher T. Kahle;Jesse Rinehart;Paola de los Heros;Angeliki Louvi

  • Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

    Pedro San-Cristobal;Diana Pacheco-Alvarez;Diana Pacheco-Alvarez;Ciaran Richardson;Aaron M. Ring

  • Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases

    Kristopher T. Kahle;Jesse Rinehart;Richard P. Lifton

  • Molecular physiology of the WNK kinases.

    Kristopher T. Kahle;Aaron M. Ring;Richard P. Lifton

  • Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.

    José Ponce-Coria;Pedro San-Cristobal;Kristopher T. Kahle;Norma Vazquez

  • Local Impermeant Anions Establish the Neuronal Chloride Concentration

    J. Glykys;V. Dzhala;K. Egawa;T Balena

  • Progressive NKCC1-Dependent Neuronal Chloride Accumulation during Neonatal Seizures

    Volodymyr I. Dzhala;Kishore V. Kuchibhotla;Joseph C. Glykys;Kristopher T. Kahle

  • Modulation of neuronal activity by phosphorylation of the K–Cl cotransporter KCC2

    Kristopher T. Kahle;Kristopher T. Kahle;Tarek Z. Deeb;Martin Puskarjov;Liliya Silayeva

  • The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+–Cl− co-transporters

    Paola De Los Heros;Dario R. Alessi;Robert Gourlay;David G. Campbell

Frequent Co-Authors

Richard P. Lifton
Richard P. Lifton Rockefeller University
Seth L. Alper
Seth L. Alper Beth Israel Deaconess Medical Center
Dandan Sun
Dandan Sun University of Pittsburgh
Kevin J. Staley
Kevin J. Staley Harvard University
Gerardo Gamba
Gerardo Gamba National Autonomous University of Mexico
Murat Gunel
Murat Gunel Yale University
Steven C. Hebert
Steven C. Hebert Yale University
Eric Delpire
Eric Delpire Vanderbilt University
Aaron M. Ring
Aaron M. Ring Yale University
Guy A. Rouleau
Guy A. Rouleau Montreal Neurological Institute and Hospital

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