World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
9612
World Ranking
16701
National Ranking
6900

Overview

Chou Long Huang is affiliated with the University of Iowa Hospitals and Clinics in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions in molecular biology, cancer research, immunology, reproductive medicine, and pharmacology.

The scientist's studies often involve topics such as ion transport and channel regulation, cancer, hypoxia, and metabolism, renal and related cancers, the reproductive system and pregnancy, endometriosis research and treatment, and apelin-related biomedical research.

Recent publications by Chou Long Huang include the following papers:

  • WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis (2020, Cancers)
  • WNK1 regulates uterine homeostasis and its ability to support pregnancy (2020, JCI Insight)
  • WNK1 as an Osmolality Sensor: Mechanism and Structure-Function Studies (2024, Journal of the American Society of Nephrology)
  • Gain-of-Function WNK4 Rescues Cell Cycle and Proliferation Defects in ClC-Kb-Deficient Thick Ascending Limb (2025, Journal of the American Society of Nephrology)

Chou Long Huang frequently collaborates with other researchers, including Zong-Lin Sie, Ruei-Yang Li, Bonifasius Putera Sampurna, Po-Jui Hsu, and Shu-Chen Liu.

The main venues for their publications are the Journal of the American Society of Nephrology, with two papers, and one paper each in Cancers and JCI Insight.

Best Publications

  • Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβγ

    Chou-Long Huang;Siyi Feng;Donald W. Hilgemann

  • Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1

    Seung Kuy Cha;Bernardo Ortega;Hiroshi Kurosu;Kevin P. Rosenblatt

  • Mechanism of Hypokalemia in Magnesium Deficiency

    Chou Long Huang;Elizabeth Kuo

  • Evidence that direct binding of Gβγ to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation

    Chou Long Huang;Paul A. Slesinger;Patrick J. Casey;Yuh Nung Jan

  • Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart

    Jian Xie;Seung Kuy Cha;Seung Kuy Cha;Sung Wan An;Makoto Kuro-O

  • Soluble Klotho Protects against Uremic Cardiomyopathy Independently of Fibroblast Growth Factor 23 and Phosphate

    Jian Xie;Joonho Yoon;Sung Wan An;Makoto Kuro-o

  • Regulation of Renal Outer Medullary Potassium Channel and Renal K+ Excretion by Klotho

    Seung Kuy Cha;Ming Chang Hu;Hiroshi Kurosu;Makoto Kuro-O

  • WNK1 activates SGK1 to regulate the epithelial sodium channel.

    Bing E. Xu;Steve Stippec;Po Yin Chu;Ahmed Lazrak

  • Mechanism of Thyrotoxic Periodic Paralysis

    Shih Hua Lin;Chou Long Huang

  • Regulation of ROMK1 channel by protein kinase A via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism

    Horng Huei Liou;Shi Sheng Zhou;Chou Long Huang

  • Binding of the G protein βγ subunit to multiple regions of G protein-gated inward-rectifying K+ channels

    Chou Long Huang;Yuh Nung Jan;Lily Y. Jan

  • Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms

    Ahmed Lazrak;Zhen Liu;Chou Long Huang

  • PIP2 activates TRPV5 and releases its inhibition by intracellular Mg2

    Jason Lee;Seung Kuy Cha;Tie Jun Sun;Chou Long Huang

  • DGKE Variants Cause a Glomerular Microangiopathy That Mimics Membranoproliferative GN

    Fatih Ozaltin;Binghua Li;Alysha Rauhauser;Sung Wan An

  • Intersectin links WNK kinases to endocytosis of ROMK1

    Guocheng He;Hao Ran Wang;Shao Kuei Huang;Chou Long Huang

  • New Insights into the Mechanism of Action of Soluble Klotho.

    George D. Dalton;Jian Xie;Sung Wan An;Chou Long Huang

  • Mechanism and Molecular Determinant for Regulation of Rabbit Transient Receptor Potential Type 5 (TRPV5) Channel by Extracellular pH

    Byung Il Yeh;Tie Jun Sun;Jason Z. Lee;Hsi Hsien Chen

  • Conformational changes of pore helix coupled to gating of TRPV5 by protons

    Byung-Il Yeh;Yung Kyu Kim;Wasey Jabbar;Chou-Long Huang

  • Association of Urinary Sodium/Potassium Ratio with Blood Pressure: Sex and Racial Differences

    S. Susan Hedayati;Abu Taher M Minhajuddin;Adeel Ijaz;Orson W Moe

  • Protein kinase C inhibits caveolae-mediated endocytosis of TRPV5.

    Seung Kuy Cha;Tao Wu;Chou Long Huang

Frequent Co-Authors

Orson W. Moe
Orson W. Moe The University of Texas Southwestern Medical Center
Melanie H. Cobb
Melanie H. Cobb The University of Texas Southwestern Medical Center
Victor L. J. Tybulewicz
Victor L. J. Tybulewicz The Francis Crick Institute
Carmay Lim
Carmay Lim Academia Sinica
Makoto Kuro-o
Makoto Kuro-o Jichi Medical University
Lutz Birnbaumer
Lutz Birnbaumer National Institutes of Health
Donald W. Hilgemann
Donald W. Hilgemann The University of Texas Southwestern Medical Center
Ilya Levental
Ilya Levental The University of Texas Health Science Center at Houston
Wen-Hui Wang
Wen-Hui Wang New York Medical College
Friedhelm Hildebrandt
Friedhelm Hildebrandt Boston Children's Hospital

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