World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
95
Citations
36951
World Ranking
1885
National Ranking
121

Research.com Recognitions

  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Victor L. J. Tybulewicz is affiliated with The Francis Crick Institute in the United Kingdom, where their research spans multiple intersecting domains within the biomedical sciences. Their publication record encompasses areas including biochemistry, genetics, molecular biology, medicine, immunology, and microbiology.

Their research covers a broad array of topics, with particular emphasis on:

  • Down syndrome and intellectual disability research
  • Genetics and neurodevelopmental disorders
  • Immune cell function and interaction
  • T-cell and B-cell immunology
  • Alzheimer's disease research and treatments
  • Genomics and rare diseases
  • Congenital heart defects research

Key subfields of their work include immunology, molecular biology, public health, environmental and occupational health, genetics, and physiology.

Among their frequent co-authors are Elizabeth Fisher, Frances K. Wiseman, Eva Lana-Elola, Suzanna Noy, and Dorota Gibbins, reflecting strong collaborative ties within their research networks.

Victor L. J. Tybulewicz has contributed to numerous scientific journals, with a notable presence in publications such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Alzheimer's & Dementia
  • Molecular Psychiatry
  • Development

Some recent papers authored or co-authored by them illustrate the scope of their research:

  • "Species-specific pace of development is associated with differences in protein stability," 2020, Science
  • "Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain," 2020, Molecular Psychiatry
  • "Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis," 2021, Nature Communications
  • "Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival," 2020, The Journal of Experimental Medicine
  • "Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration," 2022, Science Immunology

The scientist has been recognized through membership and fellowship awards, including being a Member of the European Molecular Biology Organization (EMBO) and a Fellow of The Academy of Medical Sciences, United Kingdom.

Best Publications

  • Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

    Victor L.J. Tybulewicz;Camila E. Crawford;Peter K. Jackson;Roderick T. Bronson

  • Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17.

    Salomé LeibundGut-Landmann;Olaf Groß;Matthew J Robinson;Fabiola Osorio

  • The SYK tyrosine kinase: a crucial player in diverse biological functions.

    Attila Mócsai;Jürgen Ruland;Victor L. J. Tybulewicz

  • Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.

    Andrew C. Karaplis;Arne Luz;Julia Glowacki;Roderick T. Bronson

  • Syk-Dependent Cytokine Induction by Dectin-1 Reveals a Novel Pattern Recognition Pathway for C Type Lectins

    Neil C. Rogers;Emma Wetter Slack;Alexander D. Edwards;Martijn A. Nolte

  • Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.

    Olaf Gross;Olaf Gross;Hendrik Poeck;Michael Bscheider;Catherine Dostert

  • PERINATAL LETHALITY AND BLOCKED B-CELL DEVELOPMENT IN MICE LACKING THE TYROSINE KINASE SYK

    M. Turner;P. J. Mee;P. S. Costello;O. Williams

  • Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II

    Bitao Liang;Craig Workman;Janine Lee;Claude Chew

  • A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages.

    Mary T. Crowley;Patrick S. Costello;Cheryl J. Fitzer-Attas;Martin Turner

  • A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2

    Katsue Suzuki-Inoue;Gemma L J Fuller;Angel Garcia;Johannes A Eble

  • A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

    Frances K. Wiseman;Tamara Al-Janabi;John Hardy;Annette Karmiloff-Smith

  • Primary structure and subunit stoichiometry of F1-ATPase from bovine mitochondria

    J.E. Walker;I.M. Fearnley;B.W. Gibson

  • Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

    Matthew J. Robinson;Fabiola Osorio;Marcela Rosas;Rui P. Freitas

  • Tyrosine kinase SYK: essential functions for immunoreceptor signalling

    Martin Turner;Edina Schweighoffer;Francesco Colucci;James P Di Santo

  • The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

    A. Poole;J.M. Gibbins;M. Turner;M.J. van Vugt

  • Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages

    Jurgen Herre;Andrew S J Marshall;Emmanuelle Caron;Alexander D Edwards

  • Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

    F. Connor;D. Bertwistle;P. J. Mee;G. M. Ross;G. M. Ross

  • Regulation of Blood and Lymphatic Vascular Separation by Signaling Proteins SLP-76 and Syk

    Farhad Abtahian;Anastasia Guerriero;Eric Sebzda;Min-Min Lu

  • An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes

    Aideen O'Doherty;Sandra Ruf;Sandra Ruf;Claire Mulligan;Victoria Hildreth

  • Syk is required for integrin signaling in neutrophils.

    Attila Mócsai;Meijuan Zhou;Fanying Meng;Victor L. Tybulewicz

Frequent Co-Authors

Elizabeth M. C. Fisher
Elizabeth M. C. Fisher University College London
Martin R. Turner
Martin R. Turner University of Oxford
Steve P. Watson
Steve P. Watson University of Birmingham
Francesco Colucci
Francesco Colucci University of Cambridge
Gordon D. Brown
Gordon D. Brown University of Exeter
James P. Di Santo
James P. Di Santo Institut Pasteur
John E. Walker
John E. Walker University of Cambridge
Caetano Reis e Sousa
Caetano Reis e Sousa The Francis Crick Institute
Sebastian Brandner
Sebastian Brandner University College London
Dimitris Kioussis
Dimitris Kioussis Medical Research Council

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