Jürgen Ruland focuses on Cell biology, Signal transduction, Cancer research, Innate immune system and Immunology. His work deals with themes such as T cell, T-cell receptor and Transcription factor, which intersect with Cell biology. Jürgen Ruland focuses mostly in the field of T cell, narrowing it down to matters related to Paracaspase and, in some cases, MALT1.
His study in Signal transduction is interdisciplinary in nature, drawing from both Pyrin domain and Inflammasome. His studies in Cancer research integrate themes in fields like B cell, Phosphatidylinositol, Phosphorylation, BCL10 and PTEN. His work carried out in the field of Immunology brings together such families of science as Mutation, Disease gene identification and Genetics.
Cell biology, Cancer research, Immunology, Signal transduction and Immune system are his primary areas of study. His Cell biology research incorporates themes from Receptor and Transcription factor. His studies in Cancer research integrate themes in fields like MALT1, T cell, B cell and BCL10, Lymphoma.
His study explores the link between MALT1 and topics such as Paracaspase that cross with problems in Regulator. Innate immune system, Inflammasome, Immunity, Inflammation and Acquired immune system are among the areas of Immunology where Jürgen Ruland concentrates his study. His study in Innate immune system is interdisciplinary in nature, drawing from both Chemokine, Microbiology and Virology.
Jürgen Ruland spends much of his time researching Cancer research, Cell biology, Immune system, Receptor and Immunology. His studies deal with areas such as Protein kinase B, Tumor microenvironment, B cell, Metastasis and Colorectal cancer as well as Cancer research. His biological study spans a wide range of topics, including Suppressor, PI3K/AKT/mTOR pathway and Lymphoma.
His Cell biology research is multidisciplinary, incorporating perspectives in T cell, Oxidative phosphorylation, RNA interference, Metabolic pathway and Interactome. When carried out as part of a general Immune system research project, his work on Acquired immune system is frequently linked to work in Volumetric imaging, therefore connecting diverse disciplines of study. In general Receptor study, his work on Innate immune system often relates to the realm of Fusion protein, thereby connecting several areas of interest.
His scientific interests lie mostly in Immune system, Cell biology, T-cell receptor, Innate immune system and Antigen. Jürgen Ruland works mostly in the field of Immune system, limiting it down to topics relating to Tissue homeostasis and, in certain cases, Syk, Interferon, Proto-oncogene tyrosine-protein kinase Src, MAPK/ERK pathway and Function, as a part of the same area of interest. His work blends Cell biology and Genome editing studies together.
His T-cell receptor study integrates concerns from other disciplines, such as MALT1, Adoptive cell transfer, Melanoma, Gene and Immunotherapy. In the field of Receptor and Immunology Jürgen Ruland studies Innate immune system. His research integrates issues of Tumor microenvironment, RIG-I, Cancer research and Blockade in his study of Antigen.
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Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
Vuk Stambolic;Vuk Stambolic;Akira Suzuki;Akira Suzuki;José Luis de la Pompa;José Luis de la Pompa.
DNA damage-induced activation of p53 by the checkpoint kinase Chk2.
Atsushi Hirao;Young-Yun Kong;Shuhei Matsuoka;Andrew Wakeham.
Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17.
Salomé LeibundGut-Landmann;Olaf Groß;Matthew J Robinson;Fabiola Osorio.
Nature Immunology (2007)
The SYK tyrosine kinase: a crucial player in diverse biological functions.
Attila Mócsai;Jürgen Ruland;Victor L. J. Tybulewicz.
Nature Reviews Immunology (2010)
Guidelines for the use of flow cytometry and cell sorting in immunological studies
Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Mübeccel Akdis.
European Journal of Immunology (2017)
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.
Olaf Gross;Olaf Gross;Hendrik Poeck;Michael Bscheider;Catherine Dostert.
Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity
Olaf Gross;Andreas Gewies;Katrin Finger;Martin Schäfer.
A Homozygous CARD9 Mutation in a Family with Susceptibility to Fungal Infections
Erik-Oliver Glocker;Andre Hennigs;Mohammad Nabavi;Alejandro A. Schäffer.
The New England Journal of Medicine (2009)
Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure
Jürgen Ruland;Jürgen Ruland;Gordon S Duncan;Gordon S Duncan;Andrew Elia;Andrew Elia;Ivan del Barco Barrantes;Ivan del Barco Barrantes.
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Andreas Acs.
European Journal of Immunology (2019)
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