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2025
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Immunology
Canada
2026

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Best Scientists

D-Index
221
Citations
201412
World Ranking
133
National Ranking
4

Immunology

D-Index
225
Citations
206504
World Ranking
5
National Ranking
1

Molecular Biology

D-Index
222
Citations
198179
World Ranking
10
National Ranking
1

Research.com Recognitions

  • 2026 - Research.com Immunology in Canada Leader Award
  • 2026 - Research.com Molecular Biology in Canada Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Molecular Biology in Canada Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in Canada Leader Award
  • 2023 - Research.com Genetics and Molecular Biology in Canada Leader Award
  • 2023 - Research.com Medicine in Canada Leader Award
  • 2023 - Research.com Molecular Biology in Canada Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Canada Leader Award
  • 2019 - Member of Academia Europaea
  • 2009 - Canadian Medical Hall of Fame
  • 2005 - Fellow of the American Academy of Arts and Sciences
  • 2003 - Izaak Walton Killam Memorial Prize, Canada Council
  • 2002 - Member of the National Academy of Sciences
  • 1994 - Fellow of the Royal Society, United Kingdom
  • 1986 - Fellow of the Royal Society of Canada Academy of Science

Overview

Tak W. Mak is a researcher affiliated with the Princess Margaret Cancer Centre in Canada. Their work spans multiple interconnected fields, including biochemistry, genetics, molecular biology, and medicine, with particular focus on molecular biology, immunology, oncology, genetics, and cancer research.

The research topics addressed by Tak W. Mak cover a range of important areas such as glioma diagnosis and treatment, immune cell function and interaction, microtubule and mitosis dynamics, epigenetics and DNA methylation, acute myeloid leukemia research, immune cells in cancer, and DNA repair mechanisms.

Tak W. Mak has contributed to several prominent publication venues, with repeated appearances in:

  • Cell Death and Differentiation
  • Cancer Research
  • Proceedings of the National Academy of Sciences
  • Neuro-Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)

Major recent papers featuring work or collaboration associated with Tak W. Mak include:

  • "Beyond immune checkpoint blockade: emerging immunological strategies," 2021, Nature Reviews Drug Discovery
  • "Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles," 2022, Science Immunology
  • "An aberrant STAT pathway is central to COVID-19," 2020, Cell Death and Differentiation
  • "Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function," 2020, Cell Metabolism
  • "Tumour predisposition and cancer syndromes as models to study gene-environment interactions," 2020, Nature Reviews Cancer

Tak W. Mak frequently collaborates with several researchers including:

  • Jérôme Fortin
  • Andrew Wakeham
  • Mark R. Bray
  • David W. Cescon
  • Jillian Haight

The scientist has received multiple recognitions and distinctions throughout their career. Notable awards include:

  • Member of the Academia Europaea (2019)
  • Canadian Medical Hall of Fame (2009)
  • Fellow of the American Academy of Arts and Sciences (2005)
  • Izaak Walton Killam Memorial Prize, Canada Council (2003)
  • Member of the National Academy of Sciences (2002)
  • Fellow of the Royal Society, United Kingdom (1994)
  • Fellow of the Royal Society of Canada (1986)

Best Publications

  • Regulation of cancer cell metabolism

    Rob A. Cairns;Isaac S. Harris;Tak W. Mak

  • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

    Young-Yun Kong;Hiroki Yoshida;Ildiko Sarosi;Hong-Lin Tan

  • Modulation of oxidative stress as an anticancer strategy.

    Chiara Gorrini;Isaac S. Harris;Isaac S. Harris;Tak W. Mak

  • Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4

    Paul Waterhouse;Josef M. Penninger;Emma Timms;Andrew Wakeham

  • Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

    Vuk Stambolic;Vuk Stambolic;Akira Suzuki;Akira Suzuki;José Luis de la Pompa;José Luis de la Pompa

  • Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

    Takeshi Takahashi;Tomoyuki Tagami;Sayuri Yamazaki;Toshimitsu Uede

  • Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.

    Hiroshi Takayanagi;Sunhwa Kim;Takako Koga;Takako Koga;Hiroshi Nishina

  • Caspase Functions in Cell Death and Disease

    David R. McIlwain;Thorsten Berger;Tak W. Mak

  • BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

    Emily H.-Y.A Cheng;Michael C Wei;Solly Weiler;Richard A Flavell

  • Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice

    Jo Anne L. Flynn;Marsha M. Goldstein;John Chan;Karla J. Triebold

  • Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection.

    Klaus Pfeffer;Toshifumi Matsuyama;Thomas M. Kündig;Andrew Wakeham

  • Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

    Nicholas Joza;Nicholas Joza;Santos A. Susin;Eric Daugas;William L. Stanford

  • Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis.

    Megan Cully;Han You;Arnold J. Levine;Tak W. Mak

  • DNA damage-induced activation of p53 by the checkpoint kinase Chk2.

    Atsushi Hirao;Young-Yun Kong;Shuhei Matsuoka;Andrew Wakeham

  • Differential T cell costimulatory requirements in CD28-deficient mice

    Arda Shahinian;Klaus Pfeffer;Kelvin P. Lee;Thomas M. Kündig

  • Differential requirement for caspase 9 in apoptotic pathways in vivo

    Razqallah Hakem;Razqallah Hakem;Anne Hakem;Anne Hakem;Gordon S Duncan;Gordon S Duncan;Jeffrey T Henderson

  • An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid.

    Mathias Chamaillard;Masahito Hashimoto;Yasuo Horie;Junya Masumoto

  • Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit.

    Mauricio Rosas-Ballina;Peder S. Olofsson;Mahendar Ochani;Sergio I. Valdés-Ferrer

  • A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

    Yusuke Yanagi;Yasunobu Yoshikai;Kathleen Leggett;Stephen P. Clark

  • TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

    Mark A. Lomaga;Wen Chen Yeh;Ildiko Sarosi;Gordon S. Duncan

  • Pathways of apoptotic and non-apoptotic death in tumour cells.

    Hitoshi Okada;Tak W. Mak

Frequent Co-Authors

Pamela S. Ohashi
Pamela S. Ohashi Princess Margaret Cancer Centre
Andrew Wakeham
Andrew Wakeham Princess Margaret Cancer Centre
Josef M. Penninger
Josef M. Penninger University of British Columbia
Akira Suzuki
Akira Suzuki Kobe University
John C. Roder
John C. Roder University of Toronto
Janet Rossant
Janet Rossant University of Toronto
Philipp A. Lang
Philipp A. Lang Heinrich Heine University Düsseldorf
Andrew J. Elia
Andrew J. Elia Princess Margaret Cancer Centre
Gordon S. Duncan
Gordon S. Duncan University Health Network
Karl S. Lang
Karl S. Lang University of Duisburg-Essen

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