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Biology and Biochemistry
Canada
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
92
Citations
57826
World Ranking
2158
National Ranking
61

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Canada Leader Award

Overview

Andrew Wakeham is affiliated with the Princess Margaret Cancer Centre in Canada. Their research spans multiple fields including Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology.

Their work frequently appears in prominent publication venues such as Cell Death and Differentiation, Immunity, Nature Cancer, Proceedings of the National Academy of Sciences, and Cancer Cell.

Wakeham's research covers a broad range of specialized subfields including Molecular Biology, Immunology, Hematology, Oncology, and Genetics.

The main topics addressed in their publications include:

  • Immunotherapy and Immune Responses
  • DNA Repair Mechanisms
  • Acute Myeloid Leukemia Research
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Vagus Nerve Stimulation Research
  • PI3K/AKT/mTOR signaling in cancer

Notable recent papers authored by or involving Wakeham include:

  • The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity, 2022, Immunity
  • Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas, 2020, Cancer Cell
  • Activation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungs, 2020, Nature Cancer
  • Tumor-specific cholinergic CD4+ T lymphocytes guide immunosurveillance of hepatocellular carcinoma, 2023, Nature Cancer
  • IDH1 mutation contributes to myeloid dysplasia in mice by disturbing heme biosynthesis and erythropoiesis, 2020, Blood

Wakeham collaborates frequently with several co-authors who have contributed to multiple publications alongside them. These collaborators include Tak W. Mak, Bryan E. Snow, Jillian Haight, Jérôme Fortin, and Thorsten Berger.

Best Publications

  • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

    Young-Yun Kong;Hiroki Yoshida;Ildiko Sarosi;Hong-Lin Tan

  • Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4

    Paul Waterhouse;Josef M. Penninger;Emma Timms;Andrew Wakeham

  • Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection.

    Klaus Pfeffer;Toshifumi Matsuyama;Thomas M. Kündig;Andrew Wakeham

  • Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

    Nicholas Joza;Nicholas Joza;Santos A. Susin;Eric Daugas;William L. Stanford

  • DNA damage-induced activation of p53 by the checkpoint kinase Chk2.

    Atsushi Hirao;Young-Yun Kong;Shuhei Matsuoka;Andrew Wakeham

  • Differential T cell costimulatory requirements in CD28-deficient mice

    Arda Shahinian;Klaus Pfeffer;Kelvin P. Lee;Thomas M. Kündig

  • TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

    Mark A. Lomaga;Wen Chen Yeh;Ildiko Sarosi;Gordon S. Duncan

  • Profound block in thymocyte development in mice lacking p56lck.

    T. J. Molina;K. Kishihara;D. P. Siderovskid;W. van Ewijk

  • Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

    Takehiko Sasaki;Junko Irie-Sasaki;Junko Irie-Sasaki;Russell G. Jones;Antonio J. Oliveira-dos-Santos

  • FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

    Wen-Chen Yeh;José Luis de la Pompa;Mila E. McCurrach;Hong-Bing Shu

  • Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

    Nobutaka Suzuki;Shinobu Suzuki;Gordon S. Duncan;Douglas G. Millar

  • Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

    Haruhiko Suzuki;Haruhiko Suzuki;Thomas M. Kündig;Caren Furlonger;Andrew Wakeham;Andrew Wakeham

  • High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

    Akira Suzuki;José Luis de la Pompa;Vuk Stambolic;Andrew J. Elia

  • Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

    Wen-Chen Yeh;Arda Shahinian;Daniel I Speiser;Janine Kraunus

  • Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

    Isaac S. Harris;Aislinn E. Treloar;Satoshi Inoue;Masato Sasaki

  • Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress

    Raymond H. Kim;Patrice D. Smith;Hossein Aleyasin;Shawn Hayley

  • ICOS is essential for effective T-helper-cell responses.

    Anna Tafuri;Arda Shahinian;Arda Shahinian;Friedhelm Bladt;Steve K. Yoshinaga

  • Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function

    Hans-Willi Mittrücker;Toshifumi Matsuyama;Alex Grossman;Thomas M. Kündig

  • Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4.

    A. Rahemtulla;W. P. Fung-Leung;M. W. Schilham;T. M. Kündig

  • The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse

    Razqallah Hakem;Razqallah Hakem;José Luis de la Pompa;José Luis de la Pompa;Christian Sirard;Christian Sirard;Rong Mo

Frequent Co-Authors

Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre
Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre
Pamela S. Ohashi
Pamela S. Ohashi Princess Margaret Cancer Centre
Gordon S. Duncan
Gordon S. Duncan University Health Network
Andrew J. Elia
Andrew J. Elia Princess Margaret Cancer Centre
Josef M. Penninger
Josef M. Penninger University of British Columbia
Andrew E. H. Elia
Andrew E. H. Elia Harvard University
Takehiko Sasaki
Takehiko Sasaki Tokyo Medical and Dental University
Razqallah Hakem
Razqallah Hakem University of Toronto
Thomas M. Kündig
Thomas M. Kündig University of Zurich

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