World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
97
Citations
47365
World Ranking
469
National Ranking
30

Medicine

D-Index
97
Citations
47387
World Ranking
9113
National Ranking
508

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Immune system
  • Cytokine

Klaus Pfeffer mainly investigates Immunology, Cell biology, Molecular biology, T cell and Immune system. His research on Immunology often connects related topics like Receptor. His studies in Cell biology integrate themes in fields like Cell type and Cellular differentiation.

In his study, which falls under the umbrella issue of Molecular biology, Interleukin 2 and Lamina propria is strongly linked to CD8. His T cell research is multidisciplinary, incorporating elements of Cytotoxic T cell, T lymphocyte and Cytokine. His work carried out in the field of Immune system brings together such families of science as Transcription factor, Intestinal mucosa and Pathogenesis.

His most cited work include:

  • Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation (1958 citations)
  • Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. (1605 citations)
  • Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice (1442 citations)

What are the main themes of his work throughout his whole career to date?

His main research concerns Immunology, Cell biology, Tumor necrosis factor alpha, Immune system and Molecular biology. His study looks at the intersection of Immunology and topics like Receptor with Endocrinology. His study in the field of Signal transduction, Liver regeneration and GTPase also crosses realms of Guanylate-binding protein.

His work in Tumor necrosis factor alpha addresses subjects such as Pathology, which are connected to disciplines such as Peritonitis. His research investigates the connection between Molecular biology and topics such as Germinal center that intersect with issues in Follicular dendritic cells. His biological study spans a wide range of topics, including Cytotoxic T cell and T lymphocyte.

He most often published in these fields:

  • Immunology (36.71%)
  • Cell biology (28.32%)
  • Tumor necrosis factor alpha (19.23%)

What were the highlights of his more recent work (between 2013-2021)?

  • Cell biology (28.32%)
  • Immune system (17.83%)
  • Microbiology (12.59%)

In recent papers he was focusing on the following fields of study:

Klaus Pfeffer mainly focuses on Cell biology, Immune system, Microbiology, Immunology and Tumor necrosis factor alpha. His study explores the link between Cell biology and topics such as Caspase-11 that cross with problems in Membrane glycoproteins, Legionella pneumophila, Extracellular, Lipopolysaccharide and Bacterial outer membrane. His studies deal with areas such as Progenitor cell and Cytotoxic T cell as well as Immune system.

His Microbiology research includes themes of Pseudomonas aeruginosa, Bacteria, Enterobacter cloacae and Outbreak. His study connects Respiratory tract and Immunology. His Tumor necrosis factor alpha study incorporates themes from Receptor, Cancer research, Liver cell and Programmed cell death.

Between 2013 and 2021, his most popular works were:

  • Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. (226 citations)
  • Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida (209 citations)
  • Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS (197 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Immune system
  • Cytokine

The scientist’s investigation covers issues in Cell biology, Immune system, Immunology, STAT protein and Virology. His research integrates issues of Inflammasome, Caspase-11 and DNA-binding protein in his study of Cell biology. His Immune system research integrates issues from Megakaryocyte, RNA-Seq, DNA methylation, Mural cell and Reticular cell.

His Immunology research is multidisciplinary, incorporating perspectives in Transcriptome and breakpoint cluster region. His study on 2019-20 coronavirus outbreak and Vesicular stomatitis virus is often connected to Pandemic, Genetic structure and Severe acute respiratory syndrome coronavirus 2 as part of broader study in Virology. The STAT3 study combines topics in areas such as Molecular biology and PIM1.

Best Publications

  • Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

    Nicholas Arpaia;Clarissa Campbell;Xiying Fan;Stanislav Dikiy

  • Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice

    Jo Anne L. Flynn;Marsha M. Goldstein;John Chan;Karla J. Triebold

  • Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes

    Manuel Alvarez-Dolado;Ricardo Pardal;Jose M. Garcia-Verdugo;John R. Fike

  • Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection.

    Klaus Pfeffer;Toshifumi Matsuyama;Thomas M. Kündig;Andrew Wakeham

  • Differential T cell costimulatory requirements in CD28-deficient mice

    Arda Shahinian;Klaus Pfeffer;Kelvin P. Lee;Thomas M. Kündig

  • Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.

    Jonas Schulte-Schrepping;Nico Reusch;Daniela Paclik;Kevin Baßler

  • Pretreatment of Mice with Streptomycin Provides a Salmonella enterica Serovar Typhimurium Colitis Model That Allows Analysis of Both Pathogen and Host

    Manja Barthel;Siegfried Hapfelmeier;Siegfried Hapfelmeier;Leticia Quintanilla-Martínez;Marcus Kremer

  • The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games

    Thomas Hehlgans;Klaus Pfeffer

  • Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis

    Hans Neubauer;Ana Cumano;Mathias Müller;Hong Wu

  • The Lymphotoxin β Receptor Controls Organogenesis and Affinity Maturation in Peripheral Lymphoid Tissues

    Agnes Fütterer;Karin Mink;Arne Luz;Marie H. Kosco-Vilbois

  • PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.

    Sorin Tunaru;Jukka Kero;Annette Schaub;Christian Wufka;Christian Wufka

  • B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator.

    John R Sedy;Maya Gavrieli;Karen G Potter;Michelle A Hurchla

  • Genome-wide, large-scale production of mutant mice by ENU mutagenesis

    M. H. Hrabe de Angelis;H. Flaswinkel;H. Fuchs;B. Rathkolb

  • Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

    Toshifumi Matsuyama;Toshifumi Matsuyama;Tohru Kimura;Tohru Kimura;Tohru Kimura;Motoo Kitagawa;Klaus Pfeffer;Klaus Pfeffer

  • Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice

    Kenji Kishihara;Kenji Kishihara;Josef Penninger;Josef Penninger;Valerie A. Wallace;Valerie A. Wallace;Thomas M. Kündig

  • Biological functions of tumor necrosis factor cytokines and their receptors.

    Klaus Pfeffer

  • The Salmonella Pathogenicity Island (SPI)-2 and SPI-1 Type III Secretion Systems Allow Salmonella Serovar typhimurium to Trigger Colitis via MyD88-Dependent and MyD88-Independent Mechanisms

    Siegfried Hapfelmeier;Bärbel Stecher;Manja Barthel;Marcus Kremer

  • Partial Impairment of Cytokine Responses in Tyk2-Deficient Mice

    Marina Karaghiosoff;Hans Neubauer;Caroline Lassnig;Pavel Kovarik

  • Thymic Medullary Epithelial Cell Differentiation, Thymocyte Emigration, and the Control of Autoimmunity Require Lympho–Epithelial Cross Talk via LTβR

    Thomas Boehm;Stefanie Scheu;Klaus Pfeffer;Conrad C. Bleul

  • Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice.

    Marat B. Alimzhanov;Dmitry V. Kuprash;Marie H. Kosco-Vilbois;Arne Luz

Frequent Co-Authors

Carl F. Ware
Carl F. Ware Sanford Burnham Prebys Medical Discovery Institute
Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre
Dieter Häussinger
Dieter Häussinger Heinrich Heine University Düsseldorf
Hermann Wagner
Hermann Wagner Technical University of Munich
Sergei A. Nedospasov
Sergei A. Nedospasov Lomonosov Moscow State University
Bernhard Holzmann
Bernhard Holzmann Technical University of Munich
Kenneth M. Murphy
Kenneth M. Murphy Washington University in St. Louis
Philipp A. Lang
Philipp A. Lang Heinrich Heine University Düsseldorf
Karl S. Lang
Karl S. Lang University of Duisburg-Essen
Pamela S. Ohashi
Pamela S. Ohashi Princess Margaret Cancer Centre

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